Maximum likelihood, parametric component separation and CMB B-mode detection in suborbital experiments

We investigate the performance of the parametric Maximum Likelihood component separation method in the context of the CMB B-mode signal detection and its characterization by small-scale CMB suborbital experiments. We consider high-resolution (FWHM=8') balloon-borne and ground-based observatories mapping low dust-contrast sky areas of 400 and 1000 square degrees, in three frequency channels, 150, 250, 410 GHz, and 90, 150, 220 GHz, with sensitivity of order 1 to 10 micro-K per beam-size pixel. These are chosen to be representative of some of the proposed, next-generation, bolometric experiments. We study the residual foreground contributions left in the recovered CMB maps in the pixel and harmonic domain and discuss their impact on a determination of the tensor-to-scalar ratio, r. In particular, we find that the residuals derived from the simulated data of the considered balloon-borne observatories are sufficiently low not to be relevant for the B-mode science. However, the ground-based observatories are in need of some external information to permit satisfactory cleaning. We find that if such information is indeed available in the latter case, both the ground-based and balloon-borne experiments can detect the values of r as low as ~0.04 at 95% confidence level. The contribution of the foreground residuals to these limits is found to be then subdominant and these are driven by the statistical uncertainty due to CMB, including E-to-B leakage, and noise. We emphasize that reaching such levels will require a sufficient control of the level of systematic effects present in the data.Comment: 18 pages, 12 figures, 6 table

A Comparison of Methods for Determining the Molecular Content of Model Galaxies

Recent observations indicate that star formation occurs only in the molecular phase of a galaxy's interstellar medium. A realistic treatment of star formation in simulations and analytic models of galaxies therefore requires that one determine where the transition from the atomic to molecular gas occurs. In this paper we compare two methods for making this determination in cosmological simulations where the internal structures of molecular clouds are unresolved: a complex time-dependent chemistry network coupled to a radiative transfer calculation of the dissociating ultraviolet (UV) radiation field, and a simple time-independent analytic approximation. We show that these two methods produce excellent agreement at all metallicities >~10^-2 of the Milky Way value across a very wide range of UV fields. At lower metallicities the agreement is worse, likely because time-dependent effects become important; however, there are no observational calibrations of molecular gas content at such low metallicities, so it is unclear if either method is accurate. The comparison suggests that, in many but not all applications, the analytic approximation provides a viable and nearly cost-free alternative to full time-dependent chemistry and radiative transfer.Comment: 8 pages, 7 figures, accepted to ApJ, emulateapj format. This version contains typo corrections and changes to figure presentation, but is otherwise the same as the previous versio

Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex : implications for depression?

Background: Psychological stress, particularly in chronic form, can lead to mood and cognitive dysfunction and is a major risk factor in the development of depressive states. How stress affects the brain to cause psychopathologies is incompletely understood. We sought to characterise potential depression related mechanisms by analysing gene expression and molecular pathways in the infralimbic medial prefrontal cortex (ILmPFC), following a repeated psychological stress paradigm. The ILmPFC is thought to be involved in the processing of emotionally contextual information and in orchestrating the related autonomic responses, and it is one of the brain regions implicated in both stress responses and depression. Results: Genome-wide microarray analysis of gene expression showed sub-chronic restraint stress resulted predominantly in a reduction in transcripts 24 hours after the last stress episode, with 239 genes significantly decreased, while just 24 genes had increased transcript abundance. Molecular pathway analysis using DAVID identified 8 pathways that were significantly enriched in the differentially expressed gene list, with genes belonging to the brain-derived neurotrophic factor – neurotrophin receptor tyrosine kinase 2 (BDNF-Ntrk2) pathway most enriched. Of the three intracellular signalling pathways that are downstream of Ntrk2, real-time quantitative PCR confirmed that only the PI3K-AKT-GSK3B and MAPK/ERK pathways were affected by sub-chronic stress, with the PLCγ pathway unaffected. Interestingly, chronic antidepressant treatment with the selective serotonin reuptake inhibitor, fluoxetine, prevented the stress-induced Ntrk2 and PI3K pathway changes, but it had no effect on the MAPK/ERK pathway. Conclusions: These findings indicate that abnormal BDNF-Ntrk2 signalling may manifest at a relatively early time point, and is consistent with a molecular signature of depression developing well before depression-like behaviours occur. Targeting this pathway prophylactically, particularly in depression-susceptible individuals, may be of therapeutic benefit

Assumptions of the primordial spectrum and cosmological parameter estimation

The observables of the perturbed universe, CMB anisotropy and large structures, depend on a set of cosmological parameters, as well as, the assumed nature of primordial perturbations. In particular, the shape of the primordial power spectrum (PPS) is, at best, a well motivated assumption. It is known that the assumed functional form of the PPS in cosmological parameter estimation can affect the best fit parameters and their relative confidence limits. In this paper, we demonstrate that a specific assumed form actually drives the best fit parameters into distinct basins of likelihood in the space of cosmological parameters where the likelihood resists improvement via modifications to the PPS. The regions where considerably better likelihoods are obtained allowing free form PPS lie outside these basins. In the absence of a preferred model of inflation, this raises a concern that current cosmological parameters estimates are strongly prejudiced by the assumed form of PPS. Our results strongly motivate approaches toward simultaneous estimation of the cosmological parameters and the shape of the primordial spectrum from upcoming cosmological data. It is equally important for theorists to keep an open mind towards early universe scenarios that produce features in the PPS.Comment: 11 pages, 2 figures, discussions extended, main results unchanged, matches published versio

Evading the pulsar constraints on the cosmic string tension in supergravity inflation

The cosmic string is a useful probe of the early Universe and may give us a clue to physics at high energy scales where any artificial particle accelerators cannot reach. Although one of the most promising tools is the cosmic microwave background, the constraint from gravitational waves is becoming so stringent that one may not hope to detect its signatures in the cosmic microwave background. In this paper, we construct a scenario that contains cosmic strings observable in the cosmic microwave background while evading the constraint imposed by the recent pulsar timing data. We argue that cosmic strings with relatively large tension are allowed by delaying the onset of the scaling regime. We also show that this scenario is naturally realized in the context of chaotic inflation in supergravity, where the phase transition is governed by the Hubble induced mass.Comment: 24pages, 3 figures, published in JCA

Cosmological constraints on neutrino plus axion hot dark matter: Update after WMAP-5

We update our previous constraints on two-component hot dark matter (axions and neutrinos), including the recent WMAP 5-year data release. Marginalising over sum m_nu provides m_a < 1.02 eV (95% C.L.) for the axion mass. In the absence of axions we find sum m_nu < 0.63 eV (95% C.L.).Comment: 4 pages, 1 figure, uses iopart.cls; v2 matches published versio

Constraining super-critical string/brane cosmologies with astrophysical data

We discuss fits of unconventional dark energy models to the available data from high-redshift supernovae, distant galaxies and baryon oscillations. The models are based either on brane cosmologies or on Liouville strings in which a relaxation dark energy is provided by a rolling dilaton field (Q-cosmology). Such cosmologies feature the possibility of effective four-dimensional negative-energy dust and/or exotic scaling of dark matter. We find evidence for a negative-energy dust at the current era, as well as for exotic-scaling (a^{-delta}) contributions to the energy density, with delta ~= 4, which could be due to dark matter coupling with the dilaton in Q-cosmology models. We conclude that Q-cosmology fits the data equally well with the LambdaCDM model for a range of parameters that are in general expected from theoretical considerations.Comment: 4 pages, 2 figures, Contributed to 11th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2009) 1-5 Jul 2009, Rome, Italy; J. Phys. Conf. Series to appea

Running Spectral Index from Inflation with Modulations

We argue that a large negative running spectral index, if confirmed, might suggest that there are abundant structures in the inflaton potential, which result in a fairly large (both positive and negative) running of the spectral index at all scales. It is shown that the center value of the running spectral index suggested by the recent CMB data can be easily explained by an inflaton potential with superimposed periodic oscillations. In contrast to cases with constant running, the perturbation spectrum is enhanced at small scales, due to the repeated modulations. We mention that such features at small scales may be seen by 21 cm observations in the future.Comment: 7 pages, 6 figures, v2: published in JCA

Model selection applied to reconstruction of the Primordial Power Spectrum

The preferred shape for the primordial spectrum of curvature perturbations is determined by performing a Bayesian model selection analysis of cosmological observations. We first reconstruct the spectrum modelled as piecewise linear in \log k between nodes in k-space whose amplitudes and positions are allowed to vary. The number of nodes together with their positions are chosen by the Bayesian evidence, so that we can both determine the complexity supported by the data and locate any features present in the spectrum. In addition to the node-based reconstruction, we consider a set of parameterised models for the primordial spectrum: the standard power-law parameterisation, the spectrum produced from the Lasenby & Doran (LD) model and a simple variant parameterisation. By comparing the Bayesian evidence for different classes of spectra, we find the power-law parameterisation is significantly disfavoured by current cosmological observations, which show a preference for the LD model.Comment: Minor changes to match version accepted by JCA

The Wilkinson Microwave Anisotropy Probe (WMAP) Source Catalog

We present the list of point sources found in the WMAP 5-year maps. The technique used in the first-year and three-year analysis now finds 390 point sources, and the five-year source catalog is complete for regions of the sky away from the galactic plane to a 2 Jy limit, with SNR > 4.7 in all bands in the least covered parts of the sky. The noise at high frequencies is still mainly radiometer noise, but at low frequencies the CMB anisotropy is the largest uncertainty. A separate search of CMB-free V-W maps finds 99 sources of which all but one can be identified with known radio sources. The sources seen by WMAP are not strongly polarized. Many of the WMAP sources show significant variability from year to year, with more than a 2:1 range between the minimum and maximum fluxes.Comment: 31 pages Latex with 4 embedded figures. Version accepted by the ApJ Supplement