Ganglión migratorio tibio-peroneo proximal como causa de parálisis del ciático poplíteo externo

Se present a el caso de un ganglion de la articulación tibio-peronea proximal que se extendió a la musculatura peronea, el nervio peroneo profundo, ligamento lateral externo y menisco externo y ocasionó paresia del ciático poplíteo externo. Tuvo evolución recidivante por lo cual fue intervenido en 4 oportunidades; en la última se realizó una transposición tendinos a por parálisis del nervio peroneo profundo. El paciente evolucionó satisfactoriamente con recuperación de la función y desaparición del dolor. El caso presenta interés ya que ofrece una problemática en cuanto a su origen, presentación clínica, evolución con compromiso neurológico y dificultad en el tratamiento quirúrgico resolutivo.A synovia l cyst attache d t o th e proxima l tibiofibula r join t is described . Th e cyst spreade d int o th e peronea l muscl e group , th e dee p peronea l nerve , th e fibula r collatera l ligamen t an d latera l meniscu s producin g a peronea l nerv e paresis. T h e cyst recurre d an d th e patien t underwen t surger y i n 4 times; i n th e last on e a tendinou s transpositio n wa s performe d t o resolv e a dee p peronea l nerv e paralysis. T h e patien t ha d a goo d evolutio n eit h functio n recover y an d absces e o f pain . Th e cas e illustrate s th e origin , clinica l aspects, evolutio n wit h neuropath y an d difficult sur - gica l resectio n o f this entity

Angioleiomioma de nervio periférico

Se realiza una revisión bibliográfica y se presenta un caso de angioleiomioma localizado en borde cubital de muñeca izquierda, en el ramo dorsal sensitivo del nervio cubital. Este tumor debe ser considerado en el diagnóstico diferencial de los nodulos subcutáneos dolorosos localizados en extremidades. No hemos encontrado descrito este tipo de tumor en un nervio periférico.A cas e of angioleiomyoma on the medial aspec t of the left wrist in the dorsal sensitive branch of the ulnar nerve, and a review of the literatur e are presented. This tumor should be considered in the differential diagnosis of patients who have a painful subcutaneous nodul e at the extremities. Ther e is no report in the literatur e on this type of tumor affecting a peripheral nerve

Adrenomedullin functions as an important tumor survival factor in human carcinogenesis

Adrenomedullin (AM) is a pluripotent regulatory peptide initially isolated from a human pheochromocytoma (adrenal tumor) and subsequently shown to play a critical role in cancer cell division, tumor neovascularization, and circumvention of programmed cell death, thus it is an important tumor cell survival factor underlying human carcinogenesis. A variety of neural and epithelial cancers have been shown to produce abundant amounts of AM. Recent findings have implicated elevation of serum AM with the onset of malignant expression. In addition, patients with tumors producing high levels of this peptide have a poor prognostic clinical outcome. Given that most human epithelial cancers display a microenvironment of reduced oxygen tension, it is interesting to note that AM and several of its receptors are upregulated during hypoxic insult. The existence of such a regulatory pathway has been implicated as the basis for the overexpression of AM/AM-R in human malignancies, thereby generating a subsequent autocrine/paracrine growth advantage for the tumor cell. Furthermore, AM has been implicated as a potential immune suppressor substance, inhibiting macrophage function and acting as a newly identified negative regulator of the complement cascade, protective properties which may help cancer cells to circumvent immune surveillance. Hence, AM's traditional participation in normal physiology (cited elsewhere in this issue) can be extended to a primary player in human carcinogenesis and may have clinical relevance as a biological target for the intervention of tumor progression

Flavoured soft leptogenesis and natural values of the B term

We revisit flavour effects in soft leptogenesis relaxing the assumption of universality for the soft supersymmetry breaking terms. We find that with respect to the case in which the heavy sneutrinos decay with equal rates and equal CP asymmetries for all lepton flavours, hierarchical flavour configurations can enhance the efficiency by more than two orders of magnitude. This translates in more than three order of magnitude with respect to the one-flavour approximation. We verify that lepton flavour equilibration effects related to off-diagonal soft slepton masses are ineffective for damping these large enhancements. We show that soft leptogenesis can be successful for unusual values of the relevant parameters, allowing for $B\sim {\cal O}({\rm TeV})$ and for values of the washout parameter up to $m_{\rm eff}/m_* \sim 5\times 10^{3}$.Comment: 23 pages, 5 figures postscript, Minor changes to match the published version in JHE

Lepton Number Violation from Colored States at the LHC

The possibility to search for lepton number violating signals at the Large Hadron Collider (LHC) in the colored seesaw scenario is investigated. In this context the fields that generate neutrino masses at the one-loop level are scalar and Majorana fermionic color-octets of SU(3). Due to the QCD strong interaction these states may be produced at the LHC with a favorable rate. We study the production mechanisms and decays relevant to search for lepton number violation signals in the channels with same-sign dileptons. In the simplest case when the two fermionic color-octets are degenerate in mass, one could use their decays to distinguish between the neutrino spectra. We find that for fermionic octets with mass up to about 1 TeV the number of same-sign dilepton events is larger than the standard model background indicating a promising signal for new physics.Comment: minor corrections, added reference

Higgs boson decay into 2 photons in the type~II Seesaw Model

We study the two photon decay channel of the Standard Model-like component of the CP-even Higgs bosons present in the type II Seesaw Model. The corresponding cross-section is found to be significantly enhanced in parts of the parameter space, due to the (doubly-)charged Higgs bosons' $(H^{\pm \pm})H^\pm$ virtual contributions, while all the other Higgs decay channels remain Standard Model(SM)-like. In other parts of the parameter space $H^{\pm \pm}$ (and $H^{\pm}$) interfere destructively, reducing the two photon branching ratio tremendously below the SM prediction. Such properties allow to account for any excess such as the one reported by ATLAS/CMS at $\approx 125$ GeV if confirmed by future data; if not, for the fact that a SM-like Higgs exclusion in the diphoton channel around 114-115 GeV as reported by ATLAS, does not contradict a SM-like Higgs at LEP(!), and at any rate, for the fact that ATLAS/CMS exclusion limits put stringent lower bounds on the $H^{\pm \pm}$ mass, particularly in the parameter space regions where the direct limits from same-sign leptonic decays of $H^{\pm \pm}$ do not apply.Comment: 26 pages, 7 figure

Enhancing lepton flavour violation in the supersymmetric inverse seesaw beyond the dipole contribution

In minimal supersymmetric models the $Z$-penguin usually provides sub-dominant contributions to charged lepton flavour violating observables. In this study, we consider the supersymmetric inverse seesaw in which the non-minimal particle content allows for dominant contributions of the $Z$-penguin to several lepton flavour violating observables. In particular, and due to the low-scale (TeV) seesaw, the penguin contribution to, for instance, \Br(\mu \to 3e) and $\mu-e$ conversion in nuclei, allows to render some of these observables within future sensitivity reach. Moreover, we show that in this framework, the $Z$-penguin exhibits the same non-decoupling behaviour which had previously been identified in flavour violating Higgs decays in the Minimal Supersymmetric Standard Model.Comment: 29 pages, 9 figures, 4 tables; v2: minor corrections, version to appear in JHE

Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement

The complement system is important in immunosurveillance against tumors. However, malignant cells are usually resistant to complement-mediated lysis. In this study, we examine the expression of factor H, an inhibitor of complement activation, and factor H-like protein 1 (FHL-1), its alternatively spliced form, in lung cancer. We also evaluate the potential effect of factor H/FHL-1 in the protection of lung cancer cells against the activation of the complement cascade. By Northern blot analysis we demonstrate a high expression of factor H and FHL-1 in most non-small cell lung cancer cell lines, although neuroendocrine pulmonary tumors (small cell lung carcinoma and carcinoid cell lines) had undetectable levels. Western blot analysis of conditioned medium showed the active secretion of factor H and FHL-1 by cells that were positive by Northern blot. Expression of factor H/FHL-1 mRNA was also shown in a series of non-small cell lung cancer biopsies by in situ hybridization. Interestingly, many cultured lung cancer cells were able to bind fluorescence-labeled factor H to their surfaces. Deposition of C3 fragments from normal human serum on H1264, a lung adenocarcinoma cell line, was more efficient when factor H/FHL-1 activity was blocked by specific antibodies. Blocking factor H/FHL-1 activity also enhanced the release of anaphylatoxin C5a and moderately increased the susceptibility of these cells to complement-mediated cytotoxicity. In summary, we demonstrate the expression of factor H and FHL-1 by some lung cancer cells and analyze the contribution of these proteins to the protection against complement activation

Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis

Little is known about the molecular mechanisms that control adrenomedullin (AM) production in human cancers. We demonstrate here that the expression of AM mRNA in a variety of human tumor cell lines is highly induced in a time-dependent manner by reduced oxygen tension (1% O2) or exposure to hypoxia mimetics such as desferrioxamine mesylate (DFX) or CoCl2. This AM expression seems to be under hypoxia-inducible factor-1 (HIF-1) transcriptional regulation, since HIF-1alpha and HIF-1beta knockout mouse cell lines had an ablated or greatly reduced hypoxia AM mRNA induction. Similarly, inhibition or enhancement of HIF-1 activity in human tumor cells showed an analogous modulation of AM mRNA. Under hypoxic conditions, immunohistochemical analysis of tumor cell lines revealed elevated levels of AM and HIF-1alpha as compared with normoxia, and we also found an increase of immunoreactive AM in the conditioned medium of tumor cells analyzed by RIA. AM mRNA stabilization was shown to be partially responsible for the hypoxic up-regulated expression of AM. In addition, we have identified several putative hypoxia response elements (HREs) in the human AM gene, and reporter studies with selected HREs were capable of enhancing luciferase expression after exposure to DFX. Furthermore, transient coexpression of HIF-1alpha resulted in an augmented transactivation of the reporter gene after DFX treatment. Given that most solid human tumors have focal hypoxic areas and that AM functions as a mitogen, angiogenic factor, and apoptosis-survival factor, our findings implicate the HIF-1/AM link as a possible promotion mechanism of carcinogenesis

Exploring novel correlations in trilepton channels at the LHC for the minimal supersymmetric inverse seesaw model

We investigate signatures of the minimal supersymmetric inverse seesaw model at the large hadron collider (LHC) with three isolated leptons and large missing energy (3\ell + \mET or 2\ell + 1\tau + \mET, with \ell=e,\mu) in the final state. This signal has its origin in the decay of chargino-neutralino (\chpm1\ntrl2) pair, produced in pp collisions. The two body decays of the lighter chargino into a charged lepton and a singlet sneutrino has a characteristic decay pattern which is correlated with the observed large atmospheric neutrino mixing angle. This correlation is potentially observable at the LHC by looking at the ratios of cross sections of the trilepton + \mET channels in certain flavour specific modes. We show that even after considering possible leading standard model backgrounds these final states can lead to reasonable discovery significance at the LHC with both 7 TeV and 14 TeV center-of-mass energy.Comment: 28 pages, 9 .eps figures. 3 new figures and discussions on LHC observables added, minor modifications in text and in the abstract, 23 new references added, matches with the published version in JHE