Donner en de verlichtingsdenkers

Rein Gerritsen studeerde tussen 1985 en 1993 wijsbegeerte, theoretische psychologie en wis- en natuurkunde aan de Rijksuniversiteit Utrecht. Publiceerde in diverse landelijke en regionale dag-, week- en maandbladen (waaronder NRC Handelsblad, Het Parool, Trouw, Utrechts Nieuwsblad, Natuur & Techniek, Filosofiemagazine) en schreef verschillende boeken. Sinds 2004 is hij verbonden als externe onderzoeker aan de University of Kent at Canturbury (supervisor: Dr. Jeremy Carrette).Volgens veel filosofen is ‘waarheid’ een eigenschap van bepaalde ideeën die we hebben, het is niet iets dat we zelf kunnen maken. In mijn bijdrage neem ik één wijsgerig terrein waarop wijzelf onze eigen waarheden kunnen creëren nader onder de loep: dat van ons denken over het agnosticisme, ook wel het geloofsdebat genoemd. Op de een of andere manier en in allerlei gedaanten steekt deze discussie steeds weer de kop in de geschiedenis van onze maatschappij, in haar religie, literatuur, wetenschap en wijsbegeerte. Als voorbeeld van het actuele debat over agnosticisme bediscussieer ik een aantal stellingen uit een recent boek van de Nederlandse verlichtingsfilosoof Herman Philipse, Verlichtingsfundamentalisme?, maar ik had ook Jonathan Israels Radical Enlightenment als voorbeeld kunnen nemen. Beide boeken kampen met een probleem dat zich nog het beste omschrijven laat door de woorden van Cornelis Verhoeven uit Rondom de Leegte te parafraseren: ‘Wie voortijdig de horizon dichtgrendelt met een concreet atheïsme, werkt de formulering van een godsbeeld ongewild in de hand’. Uiteindelijk draait dit debat om de vraag of mensen het recht hebben in iets te geloven, zonder dat dat wetenschappelijk verantwoord zou zijn, zoals de verlichtingsdenkers willen. Mijn antwoord daarop is: “Ja, gelukkig wel”

Про періодичні розв'язки системи сингулярно збурених диференціальних рівнянь з періодичними коефіцієнтами

Запропоновано алгоритм побудови періодичних розв'язків сингулярно збуреної системи диференціальних рівнянь з періодичними коефіцієнтами у некритичному випадку.Предложен алгоритм построения периодических решений сингулярно возмущенной системы дифференциальных уравнений с периодическими коэффициентами в некритическом случае.An algorithm of constructing the periodic solutions of a singularly perturbed system of differential equations with periodic coefficients in the uncritical case is proposed

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis

PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.PMCID: PMC385649

Kinetics Oxidation of Heavy Oil. 2. Application of Genetic Algorithm for Evaluation of Kinetic Parameters

In-situ combustion (ISC) is the process of injecting air into oil reservoirs to oxidize part of the crude-oil and has been utilized for both light and heavy oil. The viscosity of the remaining crude-oil is reduced by the significant heat generated from combustion reactions, that contributes to enhanced oil recovery. In [give citation full out], we developed a new method to interpret Ramped Temperature Oxidation (RTO) experiments using a reactor model based on a compositional and full equation of state approach. In this work, we use this RTO reactor model coupled with an optimization tool in order to determine the optimal kinetic parameters for an extra heavy oil reservoir. Kinetic parameters are commonly determined using analytical methods and limited data. Typically only one type of observational data, for example oxygen consumption, is used from one experiment. Here, we use two series of experiments data, namely CO2 and O2 concentrations and a multi objective approach to obtain kinetic parameters for the different combustion reactions. We obtain finally a set of possible kinetic schemes, accouting for all mechanisms like reactions, phase changes and transport processes

Quantitative Imaging of Protein-Protein Interactions by Multiphoton Fluorescence Lifetime Imaging Microscopy using a Streak camera

Fluorescence Lifetime Imaging Microscopy (FLIM) using multiphoton excitation techniques is now finding an important place in quantitative imaging of protein-protein interactions and intracellular physiology. We review here the recent developments in multiphoton FLIM methods and also present a description of a novel multiphoton FLIM system using a streak camera that was developed in our laboratory. We provide an example of a typical application of the system in which we measure the fluorescence resonance energy transfer between a donor/acceptor pair of fluorescent proteins within a cellular specimen.Comment: Overview of FLIM techniques, StreakFLIM instrument, FRET application

Randomized phase III KEYNOTE-045 trial of pembrolizumab versus paclitaxel, docetaxel, or vinflunine in recurrent advanced urothelial cancer: results of >2 years of follow-up.

BackgroundNovel second-line treatments are needed for patients with advanced urothelial cancer (UC). Interim analysis of the phase III KEYNOTE-045 study showed a superior overall survival (OS) benefit of pembrolizumab, a programmed death 1 inhibitor, versus chemotherapy in patients with advanced UC that progressed on platinum-based chemotherapy. Here we report the long-term safety and efficacy outcomes of KEYNOTE-045.Patients and methodsAdult patients with histologically/cytologically confirmed UC whose disease progressed after first-line, platinum-containing chemotherapy were enrolled. Patients were randomly assigned 1 : 1 to receive pembrolizumab [200 mg every 3 weeks (Q3W)] or investigator's choice of paclitaxel (175 mg/m2 Q3W), docetaxel (75 mg/m2 Q3W), or vinflunine (320 mg/m2 Q3W). Primary end points were OS and progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST v1.1) by blinded independent central radiology review (BICR). A key secondary end point was objective response rate per RECIST v1.1 by BICR.ResultsA total of 542 patients were enrolled (pembrolizumab, n = 270; chemotherapy, n = 272). Median follow-up as of 26 October 2017 was 27.7 months. Median 1- and 2-year OS rates were higher with pembrolizumab (44.2% and 26.9%, respectively) than chemotherapy (29.8% and 14.3%, respectively). PFS rates did not differ between treatment arms; however, 1- and 2-year PFS rates were higher with pembrolizumab. The objective response rate was also higher with pembrolizumab (21.1% versus 11.0%). Median duration of response to pembrolizumab was not reached (range 1.6+ to 30.0+ months) versus chemotherapy (4.4 months; range 1.4+ to 29.9+ months). Pembrolizumab had lower rates of any grade (62.0% versus 90.6%) and grade ≥3 (16.5% versus 50.2%) treatment-related adverse events than chemotherapy.ConclusionsLong-term results (>2 years' follow-up) were consistent with those of previously reported analyses, demonstrating continued clinical benefit of pembrolizumab over chemotherapy for efficacy and safety for treatment of locally advanced/metastatic, platinum-refractory UC.Trial registrationClinicalTrials.gov: NCT02256436

Cosmological Feedback from High-Redshift Dwarf Galaxies

We model how repeated supernova explosions in high-redshift dwarf starburst galaxies drive superbubbles and winds out of the galaxies. We compute the efficiencies of metal and mass ejection and energy transport from the galactic potentials, including the effect of cosmological infall of external gas. The starburst bubbles quickly blow out of small, high-redshift, galactic disks, but must compete with the ram pressure of the infalling gas to escape into intergalactic space. We show that the assumed efficiency of the star formation rate dominates the bubble evolution and the metal, mass, and energy feedback efficiencies. With star formation efficiency f*=0.01, the ram pressure of infall can confine the bubbles around high-redshift dwarf galaxies with circular velocities v_c>52 km/s. We can expect high metal and mass ejection efficiencies, and moderate energy transport efficiencies in halos with v_c~30-50 km/s and f*~0.01 as well as in halos with v_c~100 km/s and f*>>0.01. Such haloes collapse successively from 1-2 sigma peaks in LambdaCDM Gaussian density perturbations as time progresses. These dwarf galaxies can probably enrich low and high-density regions of intergalactic space with metals to 10^-3-10^-2 Zsun as they collapse at z~8 and z<5 respectively. They also may be able to provide adequate turbulent energy to prevent the collapse of other nearby halos, as well as to significantly broaden Lyman-alpha absorption lines to v_rms~20-40 km/s. We compute the timescales for the next starbursts if gas freely falls back after a starburst, and find that, for star formation efficiencies as low as f*<0.01, the next starburst should occur in less than half the Hubble time at the collapse redshift. This suggests that episodic star formation may be ubiquitous in dwarf galaxies.Comment: Accepted for ApJ v613, 60 pages, 15 figure

Star formation thresholds and galaxy edges: why and where

We study global star formation thresholds in the outer parts of galaxies by investigating the stability of disk galaxies embedded in dark halos. The disks are self-gravitating, contain metals and dust, and are exposed to UV radiation. We find that the critical surface density for the existence of a cold interstellar phase depends only weakly on the parameters of the model and coincides with the empirically derived surface density threshold for star formation. Furthermore, it is shown that the drop in the thermal velocity dispersion associated with the transition from the warm to the cold gas phase triggers gravitational instability on a wide range of scales. The presence of strong turbulence does not undermine this conclusion if the disk is self-gravitating. Models based on the hypothesis that the onset of thermal instability determines the star formation threshold in the outer parts of galaxies can reproduce many observations, including the threshold radii, column densities, and the sizes of stellar disks as a function of disk scale length and mass. Finally, prescriptions are given for implementing star formation thresholds in (semi-)analytic models and three-dimensional hydrodynamical simulations of galaxy formation.Comment: 16 pages, 6 figures, accepted for publication in the Astrophysical Journal. Version 2: text significantly revised (major improvements), physics unchanged. Version 3: minor correction

Spectroscopy of Low Surface Brightness Galaxies with the Hobby-Eberly Telescope

We have obtained low resolution spectra of nineteen red and blue low surface brightness galaxies, using the Marcario Low Resolution Spectrograph on the 9.2m Hobby-Eberly Telescope. These galaxies form a very heterogeneous class, whose spectra qualitatively resemble those of high surface brightness galaxies covering the full range of spectra seen in galaxies of Hubble types from E to Irr. We use a combination of emission line (EW(Halpha), NII/Halpha) and absorption line (Mgb, Hbeta, ) based diagnostics to investigate the star-formation and chemical enrichment histories of these galaxies. These are diverse, with some galaxies having low metallicity and very young mean stellar ages, and other galaxies showing old, super-solar metallicity stellar populations. In contrast with some previous studies which found a strong trend of decreasing metallicity with decreasing central surface brightness, we find a population of galaxies with low surface brightness and near-solar metallicity. Correlations between several of the gas phase and stellar population age and metallicity indicators are used to place contraints on plausible evolutionary scenarios for LSB galaxies. The redshift range spanned by these galaxies is broad, with radial velocities from 3400 km/s to more than 65000 km/s. A subset of the sample galaxies have published HI redshifts and gas masses based on observations with the Arecibo 305m single-dish radio telescope, which place these galaxies far off of the mean Tully-Fisher relation. Our new optical redshifts do not agree with the published HI redshifts for these galaxies. Most of the discrepancies can be explained by beam confusion in the Arecibo observations, causing erroneous HI detections for some of the galaxies.Comment: 31 pages, 12 figures, 7 tables. Uses emulateapj5.sty and onecolfloat5.sty, which are included. Accepted for publication in the Astronomical Journa

The Baryonic Tully-Fisher Relation

We explore the Tully-Fisher relation over five decades in stellar mass in galaxies with circular velocities ranging over 30 < Vc < 300 km/s. We find a clear break in the optical Tully-Fisher relation: field galaxies with Vc < 90 km/s fall below the relation defined by brighter galaxies. These faint galaxies are however very gas rich; adding in the gas mass and plotting baryonic disk mass Md = M* + Mg in place of luminosity restores a single linear relation. The Tully-Fisher relation thus appears fundamentally to be a relation between rotation velocity and total baryonic mass of the form Md = A Vc^4.Comment: 10 pages including 1 color figure. Accepted for publication in ApJ Letter