On computing joint invariants of vector fields

A constructive version of the Frobenius integrability theorem -- that can be programmed effectively -- is given. This is used in computing invariants of groups of low ranks and recover examples from a recent paper of Boyko, Patera and Popoyvich \cite{BPP}

On the local structure of Lorentzian Einstein manifolds with parallel distribution of null lines

We study transformations of coordinates on a Lorentzian Einstein manifold with a parallel distribution of null lines and show that the general Walker coordinates can be simplified. In these coordinates, the full Lorentzian Einstein equation is reduced to equations on a family of Einstein Riemannian metrics.Comment: Dedicated to Dmitri Vladimirovich Alekseevsky on his 70th birthda

Time-Dependent Multi-Centre Solutions from New Metrics with Holonomy Sim(n-2)

The classifications of holonomy groups in Lorentzian and in Euclidean signature are quite different. A group of interest in Lorentzian signature in n dimensions is the maximal proper subgroup of the Lorentz group, SIM(n-2). Ricci-flat metrics with SIM(2) holonomy were constructed by Kerr and Goldberg, and a single four-dimensional example with a non-zero cosmological constant was exhibited by Ghanam and Thompson. Here we reduce the problem of finding the general $n$-dimensional Einstein metric of SIM(n-2) holonomy, with and without a cosmological constant, to solving a set linear generalised Laplace and Poisson equations on an (n-2)-dimensional Einstein base manifold. Explicit examples may be constructed in terms of generalised harmonic functions. A dimensional reduction of these multi-centre solutions gives new time-dependent Kaluza-Klein black holes and monopoles, including time-dependent black holes in a cosmological background whose spatial sections have non-vanishing curvature.Comment: Typos corrected; 29 page

Holonomy of Einstein Lorentzian manifolds

The classification of all possible holonomy algebras of Einstein and vacuum Einstein Lorentzian manifolds is obtained. It is shown that each such algebra appears as the holonomy algebra of an Einstein (resp., vacuum Einstein) Lorentzian manifold, the direct constructions are given. Also the holonomy algebras of totally Ricci-isotropic Lorentzian manifolds are classified. The classification of the holonomy algebras of Lorentzian manifolds is reviewed and a complete description of the spaces of curvature tensors for these holonomies is given.Comment: Dedicated to to Mark Volfovich Losik on his 75th birthday. This version is an extended part of the previous version; another part of the previous version is extended and submitted as arXiv:1001.444

Spin coefficients for four-dimensional neutral metrics, and null geometry

Notation for spin coefficients for metrics of neutral signature in four dimensions is introduced. The utility and interpretation of spin coefficients is explored through themes in null geometry familiar from (complex) general relativity. Four-dimensional Walker geometry is exploited to provide examples and the generalization of the real neutral version of Pleba\~nski's (1975) second heavenly equation to certain Walker geometries given in Law and Matsushita [16] is extended further.Comment: 50 pages; minor typos corrected in v

Metrics With Vanishing Quantum Corrections

We investigate solutions of the classical Einstein or supergravity equations that solve any set of quantum corrected Einstein equations in which the Einstein tensor plus a multiple of the metric is equated to a symmetric conserved tensor $T_{\mu \nu}$ constructed from sums of terms the involving contractions of the metric and powers of arbitrary covariant derivatives of the curvature tensor. A classical solution, such as an Einstein metric, is called {\it universal} if, when evaluated on that Einstein metric, $T_{\mu \nu}$ is a multiple of the metric. A Ricci flat classical solution is called {\it strongly universal} if, when evaluated on that Ricci flat metric, $T_{\mu \nu}$ vanishes. It is well known that pp-waves in four spacetime dimensions are strongly universal. We focus attention on a natural generalisation; Einstein metrics with holonomy ${\rm Sim} (n-2)$ in which all scalar invariants are zero or constant. In four dimensions we demonstrate that the generalised Ghanam-Thompson metric is weakly universal and that the Goldberg-Kerr metric is strongly universal; indeed, we show that universality extends to all 4-dimensional ${\rm Sim}(2)$ Einstein metrics. We also discuss generalizations to higher dimensions.Comment: 23 page

A spinor approach to Walker geometry

A four-dimensional Walker geometry is a four-dimensional manifold M with a neutral metric g and a parallel distribution of totally null two-planes. This distribution has a natural characterization as a projective spinor field subject to a certain constraint. Spinors therefore provide a natural tool for studying Walker geometry, which we exploit to draw together several themes in recent explicit studies of Walker geometry and in other work of Dunajski (2002) and Plebanski (1975) in which Walker geometry is implicit. In addition to studying local Walker geometry, we address a global question raised by the use of spinors.Comment: 41 pages. Typos which persisted into published version corrected, notably at (2.15

Efficacy and Safety of Artemether in the Treatment of Chronic Fascioliasis in Egypt: Exploratory Phase-2 Trials

Fasciola hepatica and F. gigantica are two liver flukes that parasitize herbivorous large size mammals (e.g., sheep and cattle), as well as humans. A single drug is available to treat infections with Fasciola flukes, namely, triclabendazole. Recently, laboratory studies and clinical trials in sheep and humans suffering from acute fascioliasis have shown that artesunate and artemether (drugs that are widely used against malaria) also show activity against fascioliasis. Hence, we were motivated to assess the efficacy and safety of oral artemether in patients with chronic Fasciola infections. The study was carried out in Egypt and artemether administered according to two different malaria treatment regimens. Cure rates observed with 6×80 mg and 3×200 mg artemether were 35% and 6%, respectively. In addition, high efficacy was observed when triclabendazole, the current drug of choice against human fascioliasis, was administered to patients remaining Fasciola positive following artemether treatment. Concluding, monotherapy with artemether does not represent an alternative to triclabendazole against fascioliasis, but its role in combination chemotherapy regimen remains to be investigated

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly