StoRM: A Manager for Storage Resource in Grid

Nowadays, data intensive applications demand high-performance and large-storage systems capable of serving up to various Petabytes of storage space. Therefore, common solutions adopted in data centres include Storage Area Networks (SAN) and cluster parallel file systems, such as GPFS from IBM and Lustre from Sun Microsystems. In order to make these storage system solutions available in modern Data Grid architectures, standard interfaces are needed. The Grid Storage Resource Manager (SRM) interface is one of these standard interfaces. Grid storage services implementing the SRM standard provide common capabilities and advanced functionality such as dynamic space allocation and file management on shared storage systems. In this paper, we describe StoRM (STOrage Resource Manager). StoRM is a flexible and high-performing implementation of the standard SRM interface version 2.2. The software architecture of StoRM allows for an easy integration to different underlying storage systems via a plug-in mechanism. In particular, StoRM takes advantage from storage systems based on cluster file systems. Currently, StoRM is installed and used in production in various data centres, including the WLCG Italian Tier-1. In addition, Economics and Financial communities, as represented by the EGRID Project, adopt StoRM in production as well

A importância do gerenciamento de resíduos nos laboratórios de pesquisa.

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Construct-level predictive validity of educational attainment and intellectual aptitude tests in medical student selection: meta-regression of six UK longitudinal studies

Background: Measures used for medical student selection should predict future performance during training. A problem for any selection study is that predictor-outcome correlations are known only in those who have been selected, whereas selectors need to know how measures would predict in the entire pool of applicants. That problem of interpretation can be solved by calculating construct-level predictive validity, an estimate of true predictor-outcome correlation across the range of applicant abilities. Methods: Construct-level predictive validities were calculated in six cohort studies of medical student selection and training (student entry, 1972 to 2009) for a range of predictors, including A-levels, General Certificates of Secondary Education (GCSEs)/O-levels, and aptitude tests (AH5 and UK Clinical Aptitude Test (UKCAT)). Outcomes included undergraduate basic medical science and finals assessments, as well as postgraduate measures of Membership of the Royal Colleges of Physicians of the United Kingdom (MRCP(UK)) performance and entry in the Specialist Register. Construct-level predictive validity was calculated with the method of Hunter, Schmidt and Le (2006), adapted to correct for right-censorship of examination results due to grade inflation. Results: Meta-regression analyzed 57 separate predictor-outcome correlations (POCs) and construct-level predictive validities (CLPVs). Mean CLPVs are substantially higher (.450) than mean POCs (.171). Mean CLPVs for first-year examinations, were high for A-levels (.809; CI: .501 to .935), and lower for GCSEs/O-levels (.332; CI: .024 to .583) and UKCAT (mean = .245; CI: .207 to .276). A-levels had higher CLPVs for all undergraduate and postgraduate assessments than did GCSEs/O-levels and intellectual aptitude tests. CLPVs of educational attainment measures decline somewhat during training, but continue to predict postgraduate performance. Intellectual aptitude tests have lower CLPVs than A-levels or GCSEs/O-levels. Conclusions: Educational attainment has strong CLPVs for undergraduate and postgraduate performance, accounting for perhaps 65% of true variance in first year performance. Such CLPVs justify the use of educational attainment measure in selection, but also raise a key theoretical question concerning the remaining 35% of variance (and measurement error, range restriction and right-censorship have been taken into account). Just as in astrophysics, ‘dark matter’ and ‘dark energy’ are posited to balance various theoretical equations, so medical student selection must also have its ‘dark variance’, whose nature is not yet properly characterized, but explains a third of the variation in performance during training. Some variance probably relates to factors which are unpredictable at selection, such as illness or other life events, but some is probably also associated with factors such as personality, motivation or study skills

cranial nerve abnormalities in oculo auriculo vertebral spectrum

BACKGROUND AND PURPOSE: Cranial nerve abnormalities might be observed in hemifacial microsomia and microtia (oculo-auriculo-vertebral spectrum), but the rate, features, and relationship with functional impairment or phenotype severity have not yet been defined. This study aimed at investigating absence/asymmetry, abnormal origin, morphology and course of cranial nerves, and presence/asymmetry of the foramen ovale and inferior alveolar nerve canal in a cohort of oculo-auriculo-vertebral spectrum patients. MATERIALS AND METHODS: Twenty-nine patients with oculo-auriculo-vertebral spectrum (mean age, 7 years; age range, 0.2–31 years; 12 females) underwent brain MR imaging, CT, and neurologic evaluation; 19 patients had a more severe phenotype (Goldenhar syndrome). RESULTS: Cranial nerve abnormalities were detected only in patients with Goldenhar syndrome (17/19, bilaterally in 8) and were involved the second (4/19), third (1/18), fifth (11/19), sixth (8/16), seventh (11/18), and eighth (8/18) cranial nerves. Multiple cranial nerve abnormalities were common (11/17). Eleven patients showed bone foramina abnormalities. Trigeminal and facial nerve dysfunctions were common (44% and 58%, respectively), especially in patients with Goldenhar syndrome. Trigeminal abnormalities showed a good correlation with ipsilateral dysfunction ( P = .018), which further increased when bone foramina abnormalities were included. The facial nerve showed a trend toward correlation with ipsilateral dysfunction ( P = .081). Diplopia was found only in patients with Goldenhar syndrome and was associated with third and sixth cranial nerve abnormalities ( P = .006). CONCLUSIONS: Among patients with oculo-auriculo-vertebral spectrum, cranial nerve morphologic abnormalities are common, correlate with phenotype severity, and often entail a functional impairment. The spectrum of cranial nerve abnormalities appears wider than simple hypo-/aplasia and includes an anomalous cisternal course and partial/complete fusion of diverse cranial nerves. CN : cranial nerve OAVS : oculo-auriculo-vertebral spectru

Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution

Among Metazoa, bivalves have the highest lifespan disparity, ranging from 1 to 500+ years, making them an exceptional testing ground to understand mechanisms underlying aging and the evolution of extended longevity. Nevertheless, comparative molecular evolution has been an overlooked approach in this instance. Here, we leveraged transcriptomic resources spanning 30 bivalve species to unravel the signatures of convergent molecular evolution in four long-lived species: Margaritifera margaritifera, Elliptio complanata, Lampsilis siliquoidea, and Arctica islandica (the latter represents the longest-lived noncolonial metazoan known so far). We applied a comprehensive approach-which included inference of convergent dN/dS, convergent positive selection, and convergent amino acid substitution-with a strong focus on the reduction of false positives. Genes with convergent evolution in long-lived bivalves show more physical and functional interactions to each other than expected, suggesting that they are biologically connected; this interaction network is enriched in genes for which a role in longevity has been experimentally supported in other species. This suggests that genes in the network are involved in extended longevity in bivalves and, consequently, that the mechanisms underlying extended longevity are-at least partially-shared across Metazoa. Although we believe that an integration of different genes and pathways is required for the extended longevity phenotype, we highlight the potential central roles of genes involved in cell proliferation control, translational machinery, and response to hypoxia, in lifespan extension

Cochlear implantation in post-lingually deafened adults and elderly patients: analysis of audiometric and speech perception outcomes during the first year of use

Questo studio è volto alla valutazione degli outcomes audiometrici e logopedici dei pazienti anziani portatori di impianto cocleare durante il primo anno di utilizzo del dispositivo. Sono stati valutati 42 pazienti impiantati tra marzo 2010 e settembre 2014 presso lUO ORL dellAzienda Ospedaliera Universitaria di Padova. Sono stati inclusi nello studio pazienti affetti da sordità bilaterale postlinguale di grado severo-profondo impiantati unilateralmente. I soggetti sono stati divisi in tre gruppi in base allepoca della chirurgia: 14 soggetti con impianto fra i 35 e i 49 anni, 14 fra i 50 e i 64 anni e 14 impiantati a unetà superiore di 65 anni. Tutti i pazienti sono stati valutati prima e dopo la chirurgia (a 1, 3, 6 e 12 mesi di follow-up) attraverso lesecuzione di: audiometria tonale, audiometria vocale, test logopedici e somministrazione del questionario delle categorie percettive (CAP). Lanalisi statistica è stata effettuata attraverso il Students t-test. La totalità dei soggetti nei tre gruppi hanno dimostrato significativi miglioramenti allaudiometria tonale e vocale ai controlli post chirurgici rispetto alle performance ottenute precedentemente allimpianto. In particolare si sono verificati miglioramenti della soglia audiometrica media (PTA) senza differenze statisticamente significative tra i tre gruppi. risultati ottenuti nei test logopedici e dalla somministrazione del CAP hanno dimostrato evidenti miglioramenti in tutti i tre gruppi in studio. Abbiamo riscontrato, però, che i soggetti più giovani hanno raggiunto maggiori punteggi ai controlli post impianto rispetto a quelli più anziani. Concludendo, possiamo affermare che limpianto cocleare è un trattamento efficace per soggetti affetti da ipoacusia severa-profonda senza differenze significative nelle performance audiologiche e logopediche in relazione alletà di impianto. Anche se più lentamente, i pazienti impiantati dopo i 65 anni di età raggiungono performance ottimali e possono essere ritenuti dei candidati ottimali allintervento

Agronomic, nutritional and nutraceutical aspects of durum wheat (Triticum durum Desf.) cultivars under low input agricultural management

Among cereals, durum wheat has a central role in the Italian diet and economy, where there is a historical tradition of pasta making. In the present study, we evaluated the nutrient and nutraceutical properties of 2 old and 6 modern durum wheat varieties grown under low input agricultural management. Considering the lack of available data on the adaptability of existing durum wheat varieties to the low input and organic sectors, the research aimed at providing a complete description of the investigated genotypes, considering the agronomic performance as well as the nutrient and phytochemical composition. The experimental trials were carried out at the same location (Bologna, Northern Italy) for two consecutive growing seasons (2006/2007, 2007/2008). No clear distinction between old and modern varieties was observed in terms of grain yield (mean values ranging from 2.5 to 4.0 t/ha), highlighting that the divergence in productivity, normally found between dwarf and non-dwarf genotypes, is strongly reduced when they are cropped under low input management. All durum wheat varieties presented high protein levels and, in addition, provided remarkable amounts of phytochemicals such as dietary fibre, polyphenols, flavonoids and carotenoids. Some of the investigated genotypes, such as Senatore Cappelli, Solex, Svevo and Orobel, emerged with intriguing nutritional and phytochemical profiles, with the highest levels of dietary fibre and antioxidant compounds. The study provided the basis for further investigations into the adaptability of the durum wheat genotypes to low input management, for the selection of genotypes characterised by higher yield and valuable nutrient and nutraceutical quality