The effects of a chemosterilant (Mestranol) on population and behavior in the Richardson's ground squirrel (Spermophilus richardsonii) in Alberta

A chemosterilant, mestranol, was administered to three populations of Richardson's ground squirrel in southeastern Alberta. Mestranol was given to all squirrels in one plot, to only 50 percent in another plot, while a third plot remained as control. In all plots social behavior and population dynamics were followed over two seasons by live trapping and visual observations. Mestranol sterilized all females who received the drug shortly before or in early pregnancy; accordingly the birth rates were reduced. Levels of total aggression were also reduced but increased survival and immigration rates nullified the effects of the treatment during the first season. During the second season, low birth rates due to repeated treatment in one plot and to adult emigration and unknown causes in the other, were not compensated for by immigration. As a result of the repeated mestranol treatment and in one case also of adult emigration, the numbers of squirrels were reduced in the vicinity, thus limiting potential immigration in the treated plots. As a consequence, both treated populations crashed, demonstrating the effectiveness of mestranol

Variability of Temperature and Salinity in the Middle Atlantic Bight and Gulf of Maine

Monitoring of the waters of the Middle Atlantic Bight and Gulf of Maine has been conducted by the MARMAP Ships of Opportunity Program since the early 1970's. Presented in this atlas are portrayals of the temporal and spatial patterns of surface and bottom temperature and surface salinity for these areas during the period 1978-1990. These patterns are shown in the form of time-space diagrams for single-year and multiyear (base period) time frames. Each base period figure shows thirteen-year (1978-1990) mean conditions, sample variance in the form of standard deviations of the measured values, and data locations. Each single-year figure displays annual conditions, sampling locations, and departures of annual conditions from the thirteen-year means, expressed as algebraic anomalies and standardized anomalies. (PDF file contains 112 pages.

Évaluation de la capacité de rétention des métaux dissous d'un marais artificiel en utilisant le périphyton et le gastéropode Helisoma trivolvis

Le but de cette étude est de déterminer si le périphyton et le gastéropode pulmoné Helisoma trivolvis peuvent être utilisés pour évaluer la capacité de rétention des métaux dissous d'un marais construit. Cette étude a été menée dans un marais de la région d'Ottawa-Carleton (Ontario, Canada), qui a été construit en 1995 afin d'améliorer la qualité des eaux de ruissellement provenant d'un bassin versant à usage résidentiel et agricole. Au cours du mois de septembre 1999, des échantillons d'eau ont été prélevés, des escargots (H. trivolvis) ont été recoltés et un substrat artificiel a été utilisé pour faire croître du périphyton, à l'entrée et à la sortie d'eau du marais. En moyenne, les calculs de balance de masse indiquaient une rétention des formes dissoutes du Cu, Mn, Ni et Zn dans le marais. Cependant, les tendances observées pour les concentrations de métaux dissous et pour les concentrations dans les organismes différaient pour certains métaux. Les concentrations de Cd et Ni dans les tissus de H. trivolvis et le périphyton étaient significativement plus élevées à l'entrée qu'à la sortie. Cependant, les concentrations de Cr et Al dans les organismes n'étaient pas significativement différentes entre l'entrée et la sortie alors que celle de Mn était significativement plus élevée à la sortie du marais. Pour tous les métaux sauf le Cd et le Zn, les concentrations dans le périphyton étaient en moyenne plus elevées que celles dans les escargots. Le périphyton peut donc fournir une mesure plus conservatrice de la contamination du milieu pas les métaux. Cette étude montre l'importance de considérer, non-seulement les mesures chimiques, mais aussi les mesures biologiques, dans l'évaluation de l'efficacité d'un ouvrage de contrôle de pollution.Urban and agricultural development has had a significant impact on the water quality of rivers and lakes around the world. In the last few decades, constructed wetlands have been designed as wastewater treatment systems to prevent water quality deterioration in natural receiving waters. Constructed wetlands are built because they are considered sinks for many pollutants thereby protecting the water quality of downstream ecosystems. The treatment performance of these wetlands is generally assessed using mass balance calculations. However, the retention of metals by constructed wetlands is highly variable and the factors involved are still poorly understood. If wetlands are sinks for metals, the metal content of organisms should be lower downstream than upstream. In this context, organisms can be useful to assess the retention or transformation of metals by wetlands.The objective of this study was to determine whether periphyton and the gastropod Helisoma trivolvis could be used to evaluate the retention of dissolved metals in a constructed wetland. H. trivolvis is a freshwater pulmonate snail widespread in ponds across North America. It feeds mostly on periphyton and is more or less sedentary. Snails have been used as biomonitors because several species are metal tolerant. However, compared to snails, periphytic microorganisms may track more closely dissolved metal concentrations as they take up metals principally from the water column.This study was conducted at the Monahan Pond in Kanata, Ontario (Canada). This wetland was built in 1995 to treat run-off from an agricultural and residential watershed. Water chemistry samples, snails and periphyton grown on artificial substrata were collected at both the inlet and the outlet of the wetland in the fall of 1999. Tissue samples were digested with concentrated nitric acid and metal analyses were done by ICP-MS (Inductively Coupled Plasma Mass Spectrometry). During the experiment several chemical parameters differed between the inlet and the outlet. Alkalinity was significantly higher at the inflow and all major cation concentrations were higher at the inflow. The temperature was on average 3 ºC higher at the outlet. Mass balance calculations showed that the wetland was a sink for most dissolved metals. Snails and periphyton tissue metal concentrations were higher at the inflow than at the outlet for Cd and Ni. However, no significant differences were observed between inflow and outlet tissue concentrations for Cr and Al, whereas Mn was actually significantly higher at the outlet. As a result, the metal content of the organisms did not consistently reflect the dissolved metal concentrations in water. For all metals except Cd and Zn, periphyton concentrations were on average higher than snail metal concentrations. Periphyton analyses can provide a more conservative measure of metal contamination and, when artificial substrates are used, correspond to defined and known periods of exposure.This study demonstrates that constructed wetlands may lead to increased metal content of downstream organisms even if these wetlands appear to be overall sinks for dissolved metals based on mass balance calculations. It also shows the need to consider not only metal concentrations, but also biological data when assessing the performance of pollution control facilities

Self-management programmes in temporomandibular disorders: results from an international Delphi process

Self-management (SM) programmes are commonly used for initial treatment of patients with temporomandibular disorders (TMD). The programmes described in the literature, however, vary widely with no consistency in terminology used, components of care or their definitions. The aims of this study were therefore to construct an operationalised definition of self-management appropriate for the treatment of patients with TMD, identify the components of that self-management currently being used and create sufficiently clear and non-overlapping standardised definitions for each of those components. A four-round Delphi process with eleven international experts in the field of TMD was conducted to achieve these aims. In the first round, the participants agreed upon six principal concepts of self-management. In the remaining three rounds, consensus was achieved upon the definition and the six components of self-management. The main components identified and agreed upon by the participants to constitute the core of a SM programme for TMD were as follows: education; jaw exercises; massage; thermal therapy; dietary advice and nutrition; and parafunctional behaviour identification, monitoring and avoidance. This Delphi process has established the principal concepts of self-management, and a standardised definition has been agreed with the following components for use in clinical practice: education; self-exercise; self-massage; thermal therapy; dietary advice and nutrition; and parafunctional behaviour identification, monitoring and avoidance. The consensus-derived concepts, definitions and components of SM offer a starting point for further research to advance the evidence base for, and clinical utility of, TMD SM

Home parenteral nutrition with an omega-3-fatty-acid-enriched MCT/LCT lipid emulsion in patients with chronic intestinal failure (the HOME study):study protocol for a randomized, controlled, multicenter, international clinical trial

BACKGROUND: Home parenteral nutrition (HPN) is a life-preserving therapy for patients with chronic intestinal failure (CIF) indicated for patients who cannot achieve their nutritional requirements by enteral intake. Intravenously administered lipid emulsions (ILEs) are an essential component of HPN, providing energy and essential fatty acids, but can become a risk factor for intestinal-failure-associated liver disease (IFALD). In HPN patients, major effort is taken in the prevention of IFALD. Novel ILEs containing a proportion of omega-3 polyunsaturated fatty acids (n-3 PUFA) could be of benefit, but the data on the use of n-3 PUFA in HPN patients are still limited. METHODS/DESIGN: The HOME study is a prospective, randomized, controlled, double-blind, multicenter, international clinical trial conducted in European hospitals that treat HPN patients. A total of 160 patients (80 per group) will be randomly assigned to receive the n-3 PUFA-enriched medium/long-chain triglyceride (MCT/LCT) ILE (Lipidem/Lipoplus® 200 mg/ml, B. Braun Melsungen AG) or the MCT/LCT ILE (Lipofundin® MCT/LCT/Medialipide® 20%, B. Braun Melsungen AG) for a projected period of 8 weeks. The primary endpoint is the combined change of liver function parameters (total bilirubin, aspartate transaminase and alanine transaminase) from baseline to final visit. Secondary objectives are the further evaluation of the safety and tolerability as well as the efficacy of the ILEs. DISCUSSION: Currently, there are only very few randomized controlled trials (RCTs) investigating the use of ILEs in HPN, and there are very few data at all on the use of n-3 PUFAs. The working hypothesis is that n-3 PUFA-enriched ILE is safe and well-tolerated especially with regard to liver function in patients requiring HPN. The expected outcome is to provide reliable data to support this thesis thanks to a considerable number of CIF patients, consequently to broaden the present evidence on the use of ILEs in HPN. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT03282955. Registered on 14 September 2017

Grand Challenges: Improving HIV Treatment Outcomes by Integrating Interventions for Co-Morbid Mental Illness.

In the fourth article of a five-part series providing a global perspective on integrating mental health, Sylvia Kaaya and colleagues discuss the importance of integrating mental health interventions into HIV prevention and treatment platforms. Please see later in the article for the Editors' Summary

Integrating personality research and animal contest theory: aggressiveness in the green swordtail <i>Xiphophorus helleri</i>

&lt;p&gt;Aggression occurs when individuals compete over limiting resources. While theoretical studies have long placed a strong emphasis on context-specificity of aggression, there is increasing recognition that consistent behavioural differences exist among individuals, and that aggressiveness may be an important component of individual personality. Though empirical studies tend to focus on one aspect or the other, we suggest there is merit in modelling both within-and among-individual variation in agonistic behaviour simultaneously. Here, we demonstrate how this can be achieved using multivariate linear mixed effect models. Using data from repeated mirror trials and dyadic interactions of male green swordtails, &lt;i&gt;Xiphophorus helleri&lt;/i&gt;, we show repeatable components of (co)variation in a suite of agonistic behaviour that is broadly consistent with a major axis of variation in aggressiveness. We also show that observed focal behaviour is dependent on opponent effects, which can themselves be repeatable but were more generally found to be context specific. In particular, our models show that within-individual variation in agonistic behaviour is explained, at least in part, by the relative size of a live opponent as predicted by contest theory. Finally, we suggest several additional applications of the multivariate models demonstrated here. These include testing the recently queried functional equivalence of alternative experimental approaches, (e. g., mirror trials, dyadic interaction tests) for assaying individual aggressiveness.&lt;/p&gt