9,833 research outputs found
Examining the public policy perspective of CSR implementation in Sub-Saharan Africa
Purpose - The purpose of this paper is to examine the public policy perspective of corporate social responsibility (CSR) implementation in Sub-Saharan Africa. There has been an increase in the number of countries adopting a national policy for CSR practice, particularly in the Western society. Despite the growing awareness about the role of government in CSR promotion, governments in Sub-Saharan Africa are yet to evolve policies that could help promote CSR in the region. As drivers of CSR, governments hold resources, like access to regulated parts of society that makes the inclusion of CSR opportunities relevant to strategic and operational management. From the extant literature, the role of government in defining and shaping the field of CSR is gaining wider acceptability. Design/methodology/approach - Using a qualitative research approach, this paper examines the current status of CSR implementation, particularly from the public policy perspective in selected Sub-Saharan African countries. Semi-structured interviews were conducted with policymakers and policy implementers. The study adopted a thematic analysis and developed a rigorous phenomenological design to reveal the insights to CSR policy-making. Findings - The findings established that the status of CSR implementation in Sub-Saharan Africa is influenced by absence of national CSR policy, CSR being mainstreamed in government constitution and CSR being a company initiative action to comply with international code of business conduct. Practical implications - The results of this study could have policy implications for both executive and MPs of national governments for CSR regulatory policies. Originality/value - In most developing countries, including Sub-Saharan African countries, the aforementioned institutional conditions are often an exception. There are both no legal and regulatory frameworks for Multinational Corporation activities and their socio-ecological impact, or such regulations may exist but are not adequately enforced (Rwabizambuga, 2007). This situation, unfortunately, has created a huge reporting gap between what organisations do and what they report regarding CSR. Hence, this original study adds to the body of knowledge for this region by revealing the central issues around the phenomenon
Reconciling the shadow of a subduction signature with rift geochemistry and tectonic environment in Eastern Marie Byrd Land, Antarctica
Basalt-trachyte volcanoes in the Marie Byrd Land (MBL) Cenozoic province lie along the Amundsen Sea coast on the north flank of the West Antarctic rift. Basalts here are characterized by OIB-like geochemistry, restricted ranges of 87Sr/86Sr (0.702535–0.703284) and 143Nd/144Nd (0.512839–0.513008) and a wide range of 206Pb/204Pb (19.357–20.934).
Basalts at three MBL volcanoes display two anomalies compared with the above and with all other basalts in West Antarctica. They include 143Nd/144Nd (0.512778–0.512789) values at Mt. Takahe and Mt. Siple that are 2σ lower than other West Antarctic basalts, and Ba/Nb, Ba/La, and Ba/Th values at Mt. Murphy and Mt. Takahe that are 3–8 times higher than normal OIB. Isotope and trace element data do not support crustal and lithospheric mantle contamination, or the presence of residual mantle amphibole or phlogopite as explanations of these anomalies.
The apparent coincidence of these anomalies with the site of a pre-Cenozoic convergence zone along the Gondwanaland margin suggests a subduction influence. Major episodes of subduction and granitic plutonism took place in MBL during the Devonian, Permian, and Late Cretaceous. Relicts in the source region, of components from these subducted slabs, provide a credible explanation for the uncoupling of Ba from other large ion lithophile elements (LILE), for its erratic distribution, and for the anomalously low 143Nd/144Nd at Mt. Takahe.
The last episode of subduction ended ~ 85 Ma, and was followed by continental break-up, rifting and lithospheric attenuation that produced the West Antarctic rift as we know it today. Thus, the enigmatic geochemical signatures in these three volcanoes seem to have been preserved roughly 61–85 m.y. after subduction ended. New calculations of source melting depth and a new determination of lithospheric thickness suggest that the source of the anomalies resides in a fossil mélange diapir that rose from the Cretaceous subducting slab, became attached to the base of the lithosphere at 80–100 km depth, and remained there during the subsequent plate motion and source remobilization history of this region
Quasi-randomness and algorithmic regularity for graphs with general degree distributions
We deal with two intimately related subjects: quasi-randomness and regular partitions. The purpose of the concept of quasi-randomness is to express how much a given graph “resembles” a random one. Moreover, a regular partition approximates a given graph by a bounded number of quasi-random graphs. Regarding quasi-randomness, we present a new spectral characterization of low discrepancy, which extends to sparse graphs. Concerning regular partitions, we introduce a concept of regularity that takes into account vertex weights, and show that if satisfies a certain boundedness condition, then admits a regular partition. In addition, building on the work of Alon and Naor [Proceedings of the 36th ACM Symposium on Theory of Computing (STOC), Chicago, IL, ACM, New York, 2004, pp. 72–80], we provide an algorithm that computes a regular partition of a given (possibly sparse) graph in polynomial time. As an application, we present a polynomial time approximation scheme for MAX CUT on (sparse) graphs without “dense spots.
Association between Outdoor Air Pollution and Childhood Leukemia: A Systematic Review and Dose-Response Meta-Analysis.
BackgroundA causal link between outdoor air pollution and childhood leukemia has been proposed, but some older studies suffer from methodological drawbacks. To the best of our knowledge, no systematic reviews have summarized the most recently published evidence and no analyses have examined the dose-response relation.ObjectiveWe investigated the extent to which outdoor air pollution, especially as resulting from traffic-related contaminants, affects the risk of childhood leukemia.MethodsWe searched all case-control and cohort studies that have investigated the risk of childhood leukemia in relation to exposure either to motorized traffic and related contaminants, based on various traffic-related metrics (number of vehicles in the closest roads, road density, and distance from major roads), or to measured or modeled levels of air contaminants such as benzene, nitrogen dioxide, 1,3-butadiene, and particulate matter. We carried out a meta-analysis of all eligible studies, including nine studies published since the last systematic review and, when possible, we fit a dose-response curve using a restricted cubic spline regression model.ResultsWe found 29 studies eligible to be included in our review. In the dose-response analysis, we found little association between disease risk and traffic indicators near the child's residence for most of the exposure range, with an indication of a possible excess risk only at the highest levels. In contrast, benzene exposure was positively and approximately linearly associated with risk of childhood leukemia, particularly for acute myeloid leukemia, among children under 6 y of age, and when exposure assessment at the time of diagnosis was used. Exposure to nitrogen dioxide showed little association with leukemia risk except at the highest levels.DiscussionOverall, the epidemiologic literature appears to support an association between benzene and childhood leukemia risk, with no indication of any threshold effect. A role for other measured and unmeasured pollutants from motorized traffic is also possible. https://doi.org/10.1289/EHP4381
Learning Optimal Deep Projection of F-FDG PET Imaging for Early Differential Diagnosis of Parkinsonian Syndromes
Several diseases of parkinsonian syndromes present similar symptoms at early
stage and no objective widely used diagnostic methods have been approved until
now. Positron emission tomography (PET) with F-FDG was shown to be able
to assess early neuronal dysfunction of synucleinopathies and tauopathies.
Tensor factorization (TF) based approaches have been applied to identify
characteristic metabolic patterns for differential diagnosis. However, these
conventional dimension-reduction strategies assume linear or multi-linear
relationships inside data, and are therefore insufficient to distinguish
nonlinear metabolic differences between various parkinsonian syndromes. In this
paper, we propose a Deep Projection Neural Network (DPNN) to identify
characteristic metabolic pattern for early differential diagnosis of
parkinsonian syndromes. We draw our inspiration from the existing TF methods.
The network consists of a (i) compression part: which uses a deep network to
learn optimal 2D projections of 3D scans, and a (ii) classification part: which
maps the 2D projections to labels. The compression part can be pre-trained
using surplus unlabelled datasets. Also, as the classification part operates on
these 2D projections, it can be trained end-to-end effectively with limited
labelled data, in contrast to 3D approaches. We show that DPNN is more
effective in comparison to existing state-of-the-art and plausible baselines.Comment: 8 pages, 3 figures, conference, MICCAI DLMIA, 201
Tracing Spasmodic Dysphonia: the source of Ludwig Traube’s priority
Objectives: Since the mid-20th century, one citation is given historical priority as the first description of Spasmodic Dysphonia (SD): Ludwig Traube’s 1871 case of the “spastic form of nervous hoarseness”. Our objective is to understand how this case serves as the foundation of understanding laryngeal movement disorders.
Methods: The original German paper was located and translated. Bibliographical and bibliometric methods are used to determine the citation history of this original source over the past 140 years.
Results: Although secondary citations in contemporary publications typically credit Traube for establishing the clinical entity SD, his case does not conform to currently accepted diagnostic features. Citation patterns indicate the source of Traube’s priority is publications by Arnold and Luchsinger, mid-20th century ENT clinician, particularly their influential 1965 textbook used to train US and UK clinicians on voice disorders for several generations.
Conclusions: Sometimes secondary citations in medical literature lead to the inadvertent perpetuation of factual misrepresentation. The clinical picture of Traube’s original case does not represent what clinicians would recognize as SD today. The rich 19th century literature on voice disorders is a valuable resource for present day clinicians
Learning Moore Machines from Input-Output Traces
The problem of learning automata from example traces (but no equivalence or
membership queries) is fundamental in automata learning theory and practice. In
this paper we study this problem for finite state machines with inputs and
outputs, and in particular for Moore machines. We develop three algorithms for
solving this problem: (1) the PTAP algorithm, which transforms a set of
input-output traces into an incomplete Moore machine and then completes the
machine with self-loops; (2) the PRPNI algorithm, which uses the well-known
RPNI algorithm for automata learning to learn a product of automata encoding a
Moore machine; and (3) the MooreMI algorithm, which directly learns a Moore
machine using PTAP extended with state merging. We prove that MooreMI has the
fundamental identification in the limit property. We also compare the
algorithms experimentally in terms of the size of the learned machine and
several notions of accuracy, introduced in this paper. Finally, we compare with
OSTIA, an algorithm that learns a more general class of transducers, and find
that OSTIA generally does not learn a Moore machine, even when fed with a
characteristic sample
Bioavailability, Antipsoriatic Efficacy and Tolerability of a New Light Cream with Mometasone Furoate 0.1%
Mometasone furoate, a potent glucocorticoid (class III) with a favorable benefit/risk ratio, has emerged as a standard medication for the treatment of inflammatory skin disorders. The purpose of the investigation presented here was to determine the noninferiority of a topical mometasone formulation, a light cream (O/W 60/40 emulsion) with mometasone furoate 0.1% (water content of 33%) versus marketed comparators. Using the vasoconstrictor assay, a strong blanching effect of the new cream (called Mometasone cream) comparable to that of a mometasone comparator, a fatty cream with mometasone furoate 0.1%, could be demonstrated. Thus, the topical bioavailability of the active ingredient mometasone furoate (0.1%) was regarded to be similar for Mometasone cream and the mometasone comparator. Using the psoriasis plaque test, a strong antipsoriatic effect comparable to that of the mometasone comparator was found for Mometasone cream after 12 days of occlusive treatment. A nearly identical reduction in the mean infiltrate thickness and similar mean AUC values were noted with both formulations confirmed by clinical assessment data. The noninferiority of Mometasone cream to its active comparator with re-spect to the AUC of change to baseline in infiltrate thickness was demonstrated. Both medications were well tolerated. Overall, Mometasone cream and the mometasone comparator showed similar efficacy and tolerability. Mometasone cream, in addition to its high potency and good tolerability, provides the properties of a light cream, which might make this new medication particularly suitable for application on acutely inflamed and sensitive skin. Copyright (C) 2012 S. Karger AG, Base
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