Wald's entropy is equal to a quarter of the horizon area in units of the effective gravitational coupling

The Bekenstein-Hawking entropy of black holes in Einstein's theory of gravity is equal to a quarter of the horizon area in units of Newton's constant. Wald has proposed that in general theories of gravity the entropy of stationary black holes with bifurcate Killing horizons is a Noether charge which is in general different from the Bekenstein-Hawking entropy. We show that the Noether charge entropy is equal to a quarter of the horizon area in units of the effective gravitational coupling on the horizon defined by the coefficient of the kinetic term of specific graviton polarizations on the horizon. We present several explicit examples of static spherically symmetric black holes.Comment: 20 pages ; added clarifications, explanations, new section on the choice of polarizations, results unchanged; replaced with published versio

Efectos del fósforo de un efluente cloacal sobre la morfología interna y externa de Eichhornia crassipes (Mart. Solms) en un humedal artificial

Se compararon las variaciones morfológicas que presentó Eichhornia crassipes (Mart. Solms) a la entrada y salida de un humedal construido para tratar un efluente cloacal. Se determinó la concentración de fósforo en el agua y en las plantas. Se midió la altura de las plantas, la longitud de las raíces y la biomasa. Para estudiar la morfología interna de la raíz se calculó el área transversal de la raíz (ATR), de la médula (ATM) y de los vasos metaxilemáticos tardíos (ATV) y el área total del metaxilema (ATVt) por sección. Las diferentes concentraciones de fósforo presentes en el efluente cloacal, a la entrada y salida del humedal, produjeron variaciones en la morfología externa e interna de E. crassipes. La concentración de fósforo en los tejidos mostró una relación directa con la concentración de fósforo en el agua. En las plantas de la entrada se observó una mayor altura, menor longitud y biomasa de las raíces en comparación con las plantas de la salida. En las plantas de la entrada se observó un aumento de los valores de ATM y ATV y ATVt, comparadas con las plantas de la salida. La variación en los parámetros morfológicos internos se debió probablemente al aumento del área transversal de la raíz.The present study compares the morphological variation of Eichhornia crassipes (Mart. Solms) between the inlet and outlet zones of a wetland constructed for the treatment of a sewage effluent. The phosphorus concentration in water and plants was determined. Plant height, root length and dry biomass were measured. The areas of cross-sectional whole root (ATR), stele (ATM), large metaxylematic vessels (ATV) and the total metaxylematic vessels (ATVt) were calculated. The different phosphorus concentrations registered at the inlet and outlet zones of the constructed wetland, induced internal and external morphological changes in E. crassipes. Phosphorus concentration in tissues was positively correlated with phosphorus concentrations in water. The inlet zone plants were taller and they had shorter roots and less proportion of root dry weight in comparison with the outlet zone plants. The inlet zone plants increased the ATM, ATV and ATVt values, in comparison with the outlet zone plants. The variation in the internal morphological parameters was probably due to the increase of the cross-sectional whole root

Trapping cold atoms using surface-grown carbon nanotubes

We present a feasibility study for loading cold atomic clouds into magnetic traps created by single-wall carbon nanotubes grown directly onto dielectric surfaces. We show that atoms may be captured for experimentally sustainable nanotube currents, generating trapped clouds whose densities and lifetimes are sufficient to enable detection by simple imaging methods. This opens the way for a novel type of conductor to be used in atomchips, enabling atom trapping at sub-micron distances, with implications for both fundamental studies and for technological applications

Magnetic-film atom chip with 10 μ\mum period lattices of microtraps for quantum information science with Rydberg atoms

We describe the fabrication and construction of a setup for creating lattices of magnetic microtraps for ultracold atoms on an atom chip. The lattice is defined by lithographic patterning of a permanent magnetic film. Patterned magnetic-film atom chips enable a large variety of trapping geometries over a wide range of length scales. We demonstrate an atom chip with a lattice constant of 10 $\mu$m, suitable for experiments in quantum information science employing the interaction between atoms in highly-excited Rydberg energy levels. The active trapping region contains lattice regions with square and hexagonal symmetry, with the two regions joined at an interface. A structure of macroscopic wires, cut out of a silver foil, was mounted under the atom chip in order to load ultracold $^{87}$Rb atoms into the microtraps. We demonstrate loading of atoms into the square and hexagonal lattice sections simultaneously and show resolved imaging of individual lattice sites. Magnetic-film lattices on atom chips provide a versatile platform for experiments with ultracold atoms, in particular for quantum information science and quantum simulation.Comment: 7 pages, 7 figure

Particle production in string cosmology models

We compute spectra of particles produced during a dilaton-driven kinetic inflation phase within string cosmology models. The resulting spectra depend on the parameters of the model and on the type of particle and are quite varied, some increasing and some decreasing with frequency. We use an approximation scheme in which all spectra can be expressed in a nice symmetric form, perhaps hinting at a deeper symmetry of the underlying physics. Our results may serve as a starting point for detailed studies of relic abundances, dark matter candidates, and possible sources of large scale anisotropy.Comment: 20 pages, no figures, latex, RevTe

MAGE-A cancer/testis antigens inhibit MDM2 ubiquitylation function and promote increased levels of MDM4

Melanoma antigen A (MAGE-A) proteins comprise a structurally and biochemically similar sub-family of Cancer/Testis antigens that are expressed in many cancer types and are thought to contribute actively to malignancy. MAGE-A proteins are established regulators of certain cancer-associated transcription factors, including p53, and are activators of several RING finger-dependent ubiquitin E3 ligases. Here, we show that MAGE-A2 associates with MDM2, a ubiquitin E3 ligase that mediates ubiquitylation of more than 20 substrates including mainly p53, MDM2 itself, and MDM4, a potent p53 inhibitor and MDM2 partner that is structurally related to MDM2. We find that MAGE-A2 interacts with MDM2 via the N-terminal p53-binding pocket and the RING finger domain of MDM2 that is required for homo/hetero-dimerization and for E2 ligase interaction. Consistent with these data, we show that MAGE-A2 is a potent inhibitor of the E3 ubiquitin ligase activity of MDM2, yet it does not have any significant effect on p53 turnover mediated by MDM2. Strikingly, however, increased MAGE-A2 expression leads to reduced ubiquitylation and increased levels of MDM4. Similarly, silencing of endogenous MAGE-A expression diminishes MDM4 levels in a manner that can be rescued by the proteasomal inhibitor, bortezomid, and permits increased MDM2/MDM4 association. These data suggest that MAGE-A proteins can: (i) uncouple the ubiquitin ligase and degradation functions of MDM2; (ii) act as potent inhibitors of E3 ligase function; and (iii) regulate the turnover of MDM4. We also find an association between the presence of MAGE-A and increased MDM4 levels in primary breast cancer, suggesting that MAGE-A-dependent control of MDM4 levels has relevance to cancer clinically

The Genetics of Inflammatory Bowel Disease

The genetic background of inflammatory bowel disease, both Crohn's disease and ulcerative colitis, has been known for more than 2 decades. In the last 20 years, genome-wide association studies have dramatically increased our knowledge on the genetics of inflammatory bowel disease with more than 200 risk genes having been identified. Paralleling this increasing knowledge, the armamentarium of inflammatory bowel disease medications has been growing constantly. With more available therapeutic options, treatment decisions become more complex, with still many patients experiencing a debilitating disease course and a loss of response to treatment over time. With a better understanding of the disease, more effective personalized treatment strategies are looming on the horizon. Genotyping has long been considered a strategy for treatment decisions, such as the detection of thiopurine S-methyltransferase and nudix hydrolase 15 polymorphisms before the initiation of azathioprine. However, although many risk genes have been identified in inflammatory bowel disease, a substantial impact of genetic risk assessment on therapeutic strategies and disease outcome is still missing. In this review, we discuss the genetic background of inflammatory bowel disease, with a particular focus on the latest advances in the field and their potential impact on management decisions

Early-life DNA methylation profiles are indicative of age-related transcriptome changes.

BACKGROUND: Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various CNS functions are observed with brain aging and can be prevented by anti-aging interventions, but the relationship of altered methylation to gene expression is poorly understood. RESULTS: Paired analysis of the hippocampal methylome and transcriptome with aging of male and female mice demonstrates that age-related differences in methylation and gene expression are anti-correlated within gene bodies and enhancers. Altered promoter methylation with aging was found to be generally un-related to altered gene expression. A more striking relationship was found between methylation levels at young age and differential gene expression with aging. Highly methylated gene bodies and promoters in early life were associated with age-related increases in gene expression even in the absence of significant methylation changes with aging. As well, low levels of methylation in early life were correlated to decreased expression with aging. This relationship was also observed in genes altered in two mouse Alzheimer\u27s models. CONCLUSION: DNA methylation patterns established in youth, in combination with other epigenetic marks, were able to accurately predict changes in transcript trajectories with aging. These findings are consistent with the developmental origins of disease hypothesis and indicate that epigenetic variability in early life may explain differences in aging trajectories and age-related disease

Environmental, maternal, and reproductive risk factors for childhood acute lymphoblastic leukemia in Egypt : a case-control study

BACKGROUND\ud Acute lymphocytic leukemia (ALL) is the most common pediatric cancer. The exact cause is not known in most cases, but past epidemiological research has suggested a number of potential risk factors. This study evaluated associations between environmental and parental factors and the risk for ALL in Egyptian children to gain insight into risk factors in this developing country.\ud METHODS\ud We conducted a case-control design from May 2009 to February 2012. Cases were recruited from Children's Cancer Hospital, Egypt (CCHE). Healthy controls were randomly selected from the general population to frequency-match the cumulative group of cases by sex, age groups (<1; 1 - 5; >5 - 10; >10 years) and region of residence (Cairo metropolitan region, Nile Delta region (North), and Upper Egypt (South)). Mothers provided answers to an administered questionnaire about their environmental exposures and health history including those of the father. Odds ratios (ORs) and 95 % confidence intervals (CI) were calculated using logistic regression with adjustment for covariates.\ud RESULTS\ud Two hundred ninety-nine ALL cases and 351 population-based controls frequency-matched for age group, gender and location were recruited. The risk of ALL was increased with the mother's use of medications for ovulation induction (ORadj = 2.5, 95 % CI =1.2 -5.1) and to a lesser extend with her age (ORadj = 1.8, 95 % CI = 1.1 - 2.8, for mothers ≥ 30 years old). Delivering the child by Cesarean section, was also associated with increased risk (ORadj = 2.01, 95 % CI =1.24-2.81).\ud CONCLUSIONS\ud In Egypt, the risk for childhood ALL appears to be associated with older maternal age, and certain maternal reproductive factors

Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion.

Chlamydia trachomatis is the world's most prevalent bacterial sexually transmitted infection and leading infectious cause of blindness, yet it is one of the least understood human pathogens, in part due to the difficulties of in vitro culturing and the lack of available tools for genetic manipulation. Genome sequencing has reinvigorated this field, shedding light on the contemporary history of this pathogen. Here, we analyze 563 full genomes, 455 of which are novel, to show that the history of the species comprises two phases, and conclude that the currently circulating lineages are the result of evolution in different genomic ecotypes. Temporal analysis indicates these lineages have recently expanded in the space of thousands of years, rather than the millions of years as previously thought, a finding that dramatically changes our understanding of this pathogen's history. Finally, at a time when almost every pathogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of circulating genomic resistance in C. trachomatis