Channel saturation and conductance quantization in single-atom gold constrictions

Notwithstanding the discreteness of metallic constrictions, it is shown that the finite elasticity of stable, single-atom gold constrictions allows for a continuous and reversible change in conductance, thereby enabling observation of channel saturation and conductance quantization. The observed channel saturation and signature for conductance quantization is achieved by superposition of atomic/subatomic-scale oscillations on a retracting/approaching gold tip against a gold substrate of a scanning probe. Results also show that conductance histograms are neither suitable for evaluating the stability of atomic configurations through peak positions or peak height nor appropriate for assessing conductance quantization. A large number of atomic configurations with similar conductance values give rise to peaks in the conductance histogram. The positions of the peaks and counts at each peak can be varied by changing the conditions under which the histograms are made. Histogram counts below 1Go cannot necessarily be assumed to arise from single-atom constrictions

A New Class of non-Hermitian Quantum Hamiltonians with PT Symmetry

In a remarkable development Bender and coworkers have shown that it is possible to formulate quantum mechanics consistently even if the Hamiltonian and other observables are not Hermitian. Their formulation, dubbed PT quantum mechanics, replaces hermiticity by another set of requirements, notably that the Hamiltonian should be invariant under the discrete symmetry PT, where P denotes parity and T denotes time reversal. All prior work has focused on the case that time reversal is even (T^2 = 1). We generalize the formalism to the case of odd time reversal (T^2 = -1). We discover an analogue of Kramer's theorem for PT quantum mechanics, present a prototypical example of a PT quantum system with odd time reversal, and discuss potential applications of the formalism. Odd time reversal symmetry applies to fermionic systems including quarks and leptons and a plethora of models in nuclear, atomic and condensed matter physics. PT quantum mechanics makes it possible to enlarge the set of possible Hamiltonians that physicists could deploy to describe fundamental physics beyond the standard model or for the effective description of condensed matter phenomena.Comment: Replaced submitted version with accepted version; to appear in Phys Rev

The Effects of Extended Depletion Region on Noise Modeling of HEMT ’s

In this paper we present a high frequency noise model for short channel HEMTs.This model takes into account the effect of depletion region that extends into gate to drain spacing.The effect of this high field extension region on the noise performance of three HEMT structures is analytically calculated and compared with measured data

The efficacy of thuricin CD, tigecycline, vancomycin, teicoplanin, rifampicin and nitazoxanide, independently and in paired combinations against Clostridium difficile biofilms and planktonic cells

peer-reviewedBackground Thuricin CD is a two-component antimicrobial, belonging to the recently designated sactibiotic subclass of bacteriocins. The aim of this study was to investigate the effects of thuricin CD, as well as the antibiotics, tigecycline, vancomycin, teicoplanin, rifampicin and nitazoxanide when used independently and when combined at low concentrations on the viability of Clostridium difficile 20291 R027, TL178 R002, Liv022 R106, DPC6350 and VPI10463 biofilms and planktonic cells. Results On the basis of XTT (2,3-bis[2-methyloxy-4-nitro-5-sulphophenyl]-2H-tetrazolium-5-carboxanilide)-menadione biofilm viability assays, we found that thuricin CD was effective against biofilms of R027, Liv022 R106 and DPC6350 when used independently while nitazoxanide and rifampicin were also potent against biofilms of R027 and DPC6350, when applied on their own. Tigecycline was found to be effective against R027 and DPC6350 biofilms, whereas teicoplanin and vancomycin when used independently were only effective against DPC6350 biofilms. The efficacies of the antibiotics rifampicin, tigecycline, vancomycin and teicoplanin against C. difficile 20291 R027 biofilms were significantly potentiated when combined with thuricin CD, indicating effective antimicrobial combinations with this sactibiotic against R027 biofilms. However, the potency of nitazoxanide against R027 biofilms was significantly diminished when combined with thuricin CD, indicating an ineffective combination with this sactibiotic against R027 biofilms. Paired combinations of thuricin CD along with these five antibiotics were effective at diminishing the viability of DPC6350 biofilms. However, such combinations were largely ineffective against biofilms of TL178 R002, Liv022 R106 and VPI10463. Conclusions To the best of our knowledge, this is the first study to highlight the activity of a sactibiotic bacteriocin against biofilms and the first to reveal the potency of the antibiotics tigecycline, teicoplanin and nitazoxanide against C. difficile biofilms. On the basis of this study, it is apparent that different strains of C. difficile possess varying abilities to form biofilms and that the sensitivities of these biofilms to different antimicrobials and antimicrobial combinations are strain-dependent. Since the formation of relatively strong biofilms by certain C. difficile strains may contribute to increased cases of antibiotic resistance and recurrence and relapse of C. difficile infection, the findings presented in this study could provide alternative strategies to target this pathogen.HM is a researcher in Teagasc Food Research Centre and the School of Microbiology, University College Cork, funded by the Science Foundation of Ireland (SFI)-funded Centre for Science, Engineering and Technology and the Alimentary Pharmabiotic Centre Microbiome Institute (APC) Grant Number SFI/12/ RC/2273. Research in PDC, CH, MRC and RPR laboratories is supported by the Science Foundation of Ireland (SFI)-funded Centre for Science, Engineering and Technology and the APC Microbiome Institute.Science Foundation Ireland Grant Number SFI/12/RC/227

Linearization of CIF Through SOS

Linearization is the procedure of rewriting a process term into a linear form, which consist only of basic operators of the process language. This procedure is interesting both from a theoretical and a practical point of view. In particular, a linearization algorithm is needed for the Compositional Interchange Format (CIF), an automaton based modeling language. The problem of devising efficient linearization algorithms is not trivial, and has been already addressed in literature. However, the linearization algorithms obtained are the result of an inventive process, and the proof of correctness comes as an afterthought. Furthermore, the semantic specification of the language does not play an important role on the design of the algorithm. In this work we present a method for obtaining an efficient linearization algorithm, through a step-wise refinement of the SOS rules of CIF. As a result, we show how the semantic specification of the language can guide the implementation of such a procedure, yielding a simple proof of correctness.Comment: In Proceedings EXPRESS 2011, arXiv:1108.407