39 research outputs found
Indolin-2-ones with High in Vivo Efficacy in a Model for Multiple Sclerosis<sup>§</sup>
No full textThe known KDR inhibitor SU5416 and several
analogues of the indolin-2-one family were surprisingly found
to be highly efficacious in the EAE model, an established model
for multiple sclerosis. The high in vivo effect could be correlated to in vitro inhibition of the pro-inflammatory cytokine
IL-2. Activity following po administration was obtained with
several analogues and via the use of prodrugs
Quantitation and structures of oligosaccharide chains in human trachea mucin glycoproteins
No full text
