Larval development of the sidestriped shrimp (Pandalopsis dispar Rathbun) (Crustacea, Decapoda, Pandalidae) reared in the laboratory

Larval development of the sidestriped shrimp (Pandalopsis dispar) is described from larvae reared in the laboratory. The species has five zoeal stages and one postlarval stage. Complete larval morphological characteristics of the species are described and compared with those of related species of the genus. The number of setae on the margin of the telson in the first and second stages is variable: 11+12, 12+12, or 11+11. Of these, 11+12 pairs are most common. The present study confirms that what was termed the fifth stage in the original study done by Berkeley in 1930 was the sixth stage and that the fifth stage in the Berkeley’s study is comparable to the sixth stage that is described in the present study. The sixth stage has a segmented inner flagellum of the antennule and fully developed pleopods with setae. The ability to distinguish larval stages of P. dispar from larval stages of other plankton can be important for studies of the effect of climate change on marine communities in the Northeast Pacific and for marine resource management strategies

A decision support tool for response to global change in marine systems : the IMBER-ADApT Framework

Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in Fish and Fisheries 17 (2016): 1183–1193, doi:10.1111/faf.12110.Global change is occurring now, often with consequences far beyond those anticipated. Although there is a wide range of assessment approaches available to address specific aspects of global change, there is currently no framework to identify what governance responses have worked and where, what has facilitated change, and what preventative options are possible. To respond to this need, we present an integrated assessment framework that builds on knowledge learned from past experience of responses to global change, to enable decision makers, researchers, managers and local stakeholders to: (1) make decisions efficiently; (2) triage and improve their responses; and (3) evaluate where to most effectively allocate resources to reduce vulnerability and enhance resilience of coastal peoples. This integrated assessment framework, IMBER-ADApT is intended to enable and enhance decision making through the development a typology of case studies providing lessons on how the natural, social and governance systems respond to the challenges of global change. The typology is developed from a database of case studies detailing the systems affected by change, responses to change and, critically, an appraisal of these responses, generating knowledge-based solutions that can be applied to other comparable situations. Fisheries, which suffer from multiple pressures, are the current focus of the proposed framework, but it could be applied to a wide range of global change issues. IMBER-ADApT has the potential to contribute to timely, cost-effective policy and governing decision making and responses. It offers cross-scale learning to help ameliorate, and eventually prevent, loss of livelihoods, food sources and habitat

Directional wetting in anisotropic inverse opals

Porous materials display interesting transport phenomena due to the restricted motion of fluids within the nano- to micro-scale voids. Here, we investigate how liquid wetting in highly ordered inverse opals is affected by anisotropy in pore geometry. We compare samples with different degrees of pore asphericity and find different wetting patterns depending on the pore shape. Highly anisotropic structures are infiltrated more easily than their isotropic counterparts. Further, the wetting of anisotropic inverse opals is directional, with liquids filling from the side more easily. This effect is supported by percolation simulations as well as direct observations of wetting using time-resolved optical microscopy

Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers

Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine threonine kinase belonging to the PIKK family (phosphoinositide 3-kinase-like-family of protein kinase), is a critical component of the non-homologous end joining (NHEJ) pathway required for the repair of DNA double strand breaks. DNA-PKcs may be involved in breast cancer pathogenesis. Methods: We evaluated clinicopathological significance of DNA-PKcs protein expression in 1161 tumours and DNA-PKcs mRNA expression in 1950 tumours. We correlated DNA-PKcs to other markers of aggressive phenotypes, DNA repair, apoptosis and cell cycle regulation. Results: Low DNA-PKcs protein expression was associated with higher tumour grade, higher mitotic index, tumour de-differentiation and tumour type (ps<0.05). Absence of BRCA1, low XRCC1/SMUG1/APE1/Polβ were also more likely in low DNA-PKcs expressing tumours (ps<0.05). Low DNA-PKcs protein expression was significantly associated with worse breast cancer specific survival (BCCS) in univariate and multivariate analysis (ps<0.01). At the mRNA level, low DNA-PKcs was associated with PAM50.Her2 and PAM50.LumA molecular phenotypes (ps<0.01) and poor BCSS. In patients with ER positive tumours who received endocrine therapy, low DNA-PKcs (protein and mRNA) was associated with poor survival. In ER negative patients, low DNA-PKcs mRNA remains significantly associated with adverse outcome. Conclusions: Our study suggests that low DNA-PKcs expression may have prognostic and predictive significance in breast cancers

Gravitational quasinormal modes for Kerr Anti-de Sitter black holes

We investigate the quasinormal modes for gravitational perturbations of rotating black holes in four dimensional Anti-de Sitter (AdS) spacetime. The study of the quasinormal frequencies related to these modes is relevant to the AdS/CFT correspondence. Although results have been obtained for Schwarzschild and Reissner-Nordstrom AdS black holes, quasinormal frequencies of Kerr-AdS black holes are computed for the first time. We solve the Teukolsky equations in AdS spacetime, providing a second order and a Pade approximation for the angular eigenvalues associated to the Teukolsky angular equation. The transformation theory and the Regge-Wheeler-Zerilli equations for Kerr-AdS are obtained.Comment: 20 pages, 13 figures, ReVTe

Resolving a merger in a hyper-luminous submillimeter galaxy at z=2.82

We present the resolved properties of the $z=2.82$ Hyper Luminous Infrared Galaxy (HyLIRG) HS170850.1, the brightest 850$\mu$m source found in the SCUBA-2 followup to the Keck Baryonic Structure Survey fields (S$_{\rm 850 \mu m}=$19.5 mJy), and amongst the most luminous starbursts known at any redshift. Using the IRAM-NOEMA interferometer in the highest resolution A-configuration, we resolve the source into two components separated by $\sim$8 kpc, visible as blue shifted and red shifted $^{12}$CO(5-4) lines, exhibiting the expected kinematic properties of a major merger between two gas-rich galaxies. The combined merger system is traced over 2.3$''$ or 18.3 kpc. Each component of the merger shows ordered gas motions suggestive of a massive, turbulent disk. We measure the masses of the blue and red disks as (1.5 $\pm$ 0.2) $\times10^{11}$ M$_\odot$ and (0.71 $\pm$ 0.22) $\times10^{11}$ M$_\odot$ respectively. The more massive disk component shows broad wings in the CO line, offset by $\sim$3 kpc from the disk centroid along the major axis, and extending to velocities $\sim\pm$1000 km $\rm{s^{-1}}$ from systemic velocity. We interpret this as either a possible bipolar outflowing component, or more likely a warping or tidal structure in the CO disk. Comparing the properties of HS170850.1 to other submillimeter detected galaxies with comparably bright 850$\mu$m luminosities suggests that ongoing gas-rich mergers, or at least a clustered/group environment lead to these most extreme starburst phases.Comment: 13 pages, 5 Figures, 2 Table

Ensembl regulation resources

New experimental techniques in epigenomics allow researchers to assay a diversity of highly dynamic features such as histone marks, DNA modifications or chromatin structure. The study of their fluctuations should provide insights into gene expression regulation, cell differentiation and disease. The Ensembl project collects and maintains the Ensembl regulation data resources on epigenetic marks, transcription factor binding and DNA methylation for human and mouse, as well as microarray probe mappings and annotations for a variety of chordate genomes. From this data, we produce a functional annotation of the regulatory elements along the human and mouse genomes with plans to expand to other species as data becomes available. Starting from well-studied cell lines, we will progressively expand our library of measurements to a greater variety of samples. Ensembl's regulation resources provide a central and easy-to-query repository for reference epigenomes. As with all Ensembl data, it is freely available at http://www.ensembl.org, from the Perl and REST APIs and from the public Ensembl MySQL database server at ensembldb.ensembl.org.Database URL: http://www.ensembl.org.Wellcome Trust grant: (WT098051); National Human Genome Research Institute grants: (U41HG007234, 1U01 HG004695); Biotechnology and Biological Sciences Research Council grant: (BB/L024225/1); European Molecular Biology Laboratory; European Union’s Seventh Framework Programme; European Research Council

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo