1,748 research outputs found
The spatial experiences of dwarfs in public spaces
Dwarfism is commonly defined as anyone 4ft 10″ (147.32 cm) or below and whose short stature involves a medical condition [Adelson, M. B. 2005. The Lives of Dwarfs, xv. NJ: Rutgers University Press]. Whilst it recognized that the built environment is unsuitable for dwarfs [see Kruse, R. 2002. “Social Spaces of Little People: The Experiences of the Jamisons.” Social and Cultural Geography 3 (2): 175–191, Kruse, R. 2010. “Placing Little People: Dwarfism and Geographies of Everyday Life.” In Towards Enabling Geographies, edited by V. Chouinard, E. Hall, and R. Wilton, 183–198. Surrey: Ashgate; Shakespeare, T., M. Wright, and S. Thompson. 2007. A Small Matter of Equality: Living with Restricted Growth. Newcastle: Newcastle University], this paper critically examines how spaces and facilities designed with other users in mind, including disabled people and children, can have unintended consequences for dwarfs. The data used in this paper are taken from semi-structured interviews and photo elicitation exercises conducted with 22 dwarfs living in the UK. Overall this paper shows the spatial experiences of dwarfs, which are a result of the unintended consequences of disabled child spaces and facilities, and suggests how Universal Design may be a more appropriate design concept
Sexually transmitted infection risk exposure among black and minority ethnic youth in northwest London: findings from a study translating a sexually transmitted infection risk-reduction intervention to the UK setting.
OBJECTIVES: Young black women are disproportionately affected by sexually transmitted infections (STI) in the UK, but effective interventions to address this are lacking. The Young Brent Project explored the nature and context of sexual risk-taking in young people to inform the translation of an effective clinic-based STI reduction intervention (Project SAFE) from the USA to the UK. METHODS: One-to-one in-depth interviews (n = 37) and group discussions (n = 10) were conducted among men and women aged 15-27 years from different ethnic backgrounds recruited from youth and genitourinary medicine clinic settings in Brent, London. The interviews explored the context within which STI-related risks were assessed, experienced and avoided, the skills needed to recognise risk and the barriers to behaviour change. RESULTS: Concurrent sexual partnerships, mismatched perceptions and expectations, and barriers to condom use contributed to STI risk exposure and difficulties in implementing risk-reduction strategies. Women attempted to achieve monogamy, but experienced complex and fluid sexual relationships. Low risk awareness, flawed partner risk assessments, negative perceptions of condoms and lack of control hindered condom use. Whereas men made conscious decisions, women experienced persuasion, deceit and difficulty in requesting condom use, particularly with older partners. CONCLUSIONS: Knowledge of STI and condom use skills is not enough to equip young people with the means to reduce STI risk. Interventions with young women need to place greater emphasis on: entering and maintaining healthy relationships; awareness of risks attached to different forms of concurrency and how concurrency arises; skills to redress power imbalances and building self-esteem
Virus host shifts in Drosophila: The influences of virus genotype and coinfection on susceptibility within and across host species
Virus host shifts are a major source of outbreaks and emerging infectious diseases, and continue to cause considerable damage to public health, society, and the global economy. Predicting and preventing future virus host shifts has become a primary goal of infectious disease research, and multiple tools and approaches are being developed to work towards this goal. In this thesis, I examine three key aspects of infection that have implications for our wider understanding of virus host shifts and their predictability in natural systems: whether the outcome of infections across species is correlated between related viruses, whether the presence of a coinfecting virus can alter the outcomes of cross-species transmission, and the influence of host genetics and immunity on the outcomes of coinfection. These experiments make use of a large and evolutionarily diverse panel of Drosphilidae host species, and infections with two insect Cripaviruses: Drosophila C virus (DCV) and Cricket Paralysis virus (CrPV), with the outcomes of infection quantified throughout as viral loads via qRT-PCR.
In Chapter Two, phylogenetic generalised linear mixed models are applied to data on the outcome of single infections with three isolates of DCV (DCV-C, DCV-EB, DCV-M) and one isolate of CrPV, to look for correlations in viral load across host species. Strong positive corrections were found between DCV isolates and weaker positive correlations between DCV and CrPV, with evidence of host species by virus interactions on the outcome of infection. Of the four viruses tested, the most closely related isolates tended to be the most strongly correlated, with correlation strength deteriorating with the evolutionary distance between isolates, although we lacked the diversity or sample size of viruses to properly determine any effect of evolutionary distance on correlation strength. Together, this suggests that hosts susceptible to one virus are also susceptible to closely related viruses, and that knowledge of one virus may be extrapolated to closely related viruses, at least within the range of evolutionary divergence tested here.
In the remainder of this thesis, I examine the outcome of coinfection with DCV-C and CrPV across host species (Chapter Three) and across genotypes and immune mutants of Drosophila melanogaster (Chapter Four). These chapters aim to assess the potential for coinfection to alter the outcomes of cross-species transmission – and so interfere with predictions of virus host shifts – and the potential influence of host genetics and immunity on the outcome of coinfection. Chapter Three finds little evidence of systematic changes in the outcome of single and coinfection for both viruses across species, suggesting that coinfection may not be a required consideration in predictive models of every host-virus system. Effects of coinfection were found in a subset of species but were not recapitulated in a follow-up experiment looking at tissue tropism during coinfection on a subset of host species. Together, this suggests that any effects of coinfection across species with DCV and CrPV are due to stochastic effects within individual hosts. Chapter Four finds small but credible effects of coinfection across genotypes of D. melanogaster, but these effects showed little host genetic basis or effect on the genetic basis of susceptibility to each virus separately. Mutations in several immune genes caused virus-specific changes in viral load between single and coinfection, suggesting that coinfection interactions between viruses can be moderated by the host immune response.
This thesis has aimed to explore several fundamental features of cross-species transmission that are relevant to our understanding – and ability to predict – virus host shifts. Both the finding that correlations exist between viruses and the approach used to characterise coinfection across and within host species would now benefit from an increased diversity of experimental pathogens, to better investigate the influence of virus evolutionary relationships on the outcomes of virus host shifts and present a broader understanding of the potential impact of coinfection on the outcomes of cross-species transmission.Natural Environment Research Council (NERC
Assessing the number of users who are excluded by domestic heating controls
This is the pre-print version of the Article. This Article is also referred to as: "Assessing the 'Design Exclusion' of Heating Controls at a Low-Cost, Low-Carbon Housing Development". - Copyright @ 2011 Taylor & FrancisSpace heating accounts for almost 60% of the energy delivered to housing which in turn accounts for nearly 27% of the total UK's carbon emissions. This study was conducted to investigate the influence of heating control design on the degree of ‘user exclusion’. This was calculated using the Design Exclusion Calculator, developed by the Engineering Design Centre at the University of Cambridge. To elucidate the capability requirements of the system, a detailed hierarchical task analysis was produced, due to the complexity of the overall task. The Exclusion Calculation found that the current design placed excessive demands upon the capabilities of at least 9.5% of the UK population over 16 years old, particularly in terms of ‘vision’, ‘thinking’ and ‘dexterity’ requirements. This increased to 20.7% for users over 60 years old. The method does not account for the level of numeracy and literacy and so the true exclusion may be higher. Usability testing was conducted to help validate the results which indicated that 66% of users at a low-carbon housing development could not programme their controls as desired. Therefore, more detailed analysis of the cognitive demands placed upon the users is required to understand where problems within the programming process occur. Further research focusing on this cognitive interaction will work towards a solution that may allow users to behave easily in a more sustainable manner
Mind the gap? The persistence of pathological discourses in urban regeneration policy
Urban regeneration policy has historically framed policy problems using a discourse that pathologises areas and spatial communities. Since 2001 in England, and 2002 in Scotland a structural change in policy has occurred where citywide partnerships are now meant overcome structural spatial inequalities, countering pathological explanations. This paper uses historical and discourse analysis to evaluate one of the major community regeneration strategies developed by the Scottish Executive in 2002: Better Communities in Scotland: Closing the Gap. It seeks to ask whether structural change in policy was paralleled by discursive change; what discursive path dependence is evidenced? The text is placed in the historic context of UK urban renewal policies dating back to the launch of the Urban Programme in 1968 and particularly the policy discourse created by the influential Conservative government policy of 1988 New Life for Urban Scotland and the wider discourses of poverty and neighbourhood renewal policy created by Labour governments since 1997. The close textual analysis of the text shows that Better Communities in Scotland continues to pathologise spatial communities. Although this suggests a degree of historical path dependency, the historic breadth of the analysis also problematises simple historical determinism
Theorising Disability: Beyond Common Sense
This article seeks to introduce the topic of disability to political theory via a discussion of some of the literature produced by disability theorists. The author argues that these more radical approaches conceptualise disability in ways that conflict with ‘common-sense’ notions of disability that tend to underpin political theoretical considerations of the topic. Furthermore, the author suggests that these more radical conceptualisations have profound implications for current debates on social justice, equality and citizenship that highlight the extent to which these notions are also currently underpinned by ‘common-sense’ notions of ‘normality’
On the side of the angels: community involvement in the governance of neighbourhood renewal.
This article draws upon the authors’ experiences of community-led regeneration developed while members of the National Evaluation Team for the NDC Programme. The article continues the focus on urban regeneration adopted in a range of outputs from two of the authors over the last decade. In assessing how the term community has been defined by policy-makers and the challenges involved in empowering communities, the output was aimed at both academic and user communities. For its direct relevance to communities involved in regeneration, the article was awarded the 2006 Sam Aaronovitch Prize, awarded annually by the journal Local Economy
Star Architecture as Socio-Material Assemblage
Taking inspiration from new materialism and assemblage, the chapter deals with star architects and iconic buildings as socio-material network effects that do not pre-exist action, but are enacted in practice, in the materiality of design crafting and city building. Star architects are here conceptualized as part of broader assemblages of actors and practices ‘making star architecture’ a reality, and the buildings they design are considered not just as unique and iconic objects, but dis-articulated as complex crafts mobilizing skills, technologies, materials, and forms of knowledge not necessarily ascribable to architecture. Overcoming narrow criticism focusing on the symbolic order of icons as unique creations and alienated repetitions of capitalist development, the chapter’s main aim is to widen the scope of critique by bridging culture and economy, symbolism and practicality, making star architecture available to a broad, fragmented arena of (potential) critics, unevenly equipped with critical tools and differentiated experiences
Assessing the spatial impact of policy interventions on real-estate values: an exemplar of the use of the hybrid hedonic/repeat-sales method
This paper sets out to make a contribution to the extensive literature that seeks to develop methods that allow rigorous and robust analysis of the spatial and temporal impacts of public policy interventions on property (real-estate) values. It argues that the hybrid repeat-sales/hedonic method developed in real-estate studies over the last 30 years has considerable, but as yet under-developed, potential as a policy analysis tool. Using data from Glasgow, UK, the empirical analysis illustrates how the technique can be used to understand the spatial spillovers and the dynamic temporal effects of a historic £100 million state-led, area-based, urban-renewal programme, New Life for Urban Scotland. The paper concludes by arguing that, with the rise in the availability of rich geocoded, micro-datasets, this framework is sufficiently flexible to be used to evaluate the real-estate market impacts of a wide range of public policy interventions. Significantly, as the case study demonstrates, the framework overcomes some of the sustained criticisms of the more commonly used hedonic modelling approach. There is, however, still much to do to enhance the technical qualities of the models through further application
Please mind the gap: students’ perspectives of the transition in academic skills between A-level and degree level geography
This paper explores first-year undergraduates’ perceptions of the transition from studying geography at pre-university level to studying for a degree. This move is the largest step students make in their education, and the debate about it in the UK has been reignited due to the government’s planned changes to A-level geography. However, missing from most of this debate is an appreciation of the way in which geography students themselves perceive their transition to university. This paper begins to rectify this absence. Using student insights, we show that their main concern is acquiring the higher level skills required for university learning
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