Cyanomethylene-bis(phosphonate) as ditopical ligand: stepwise formation of a 2-D heterometallic Fe(III)-Ag(I) coordination network

A new heteroditopic ligand, cyanomethylene-bis(5,5-dimethyl-2-oxo-1,3,2 lambda(5)-dioxa-phosphorinane) 1 (bphosCN), has been reacted with Fe(ClO4)(3) to afford the mononuclear complex Fe(bphosCN)(3) 2 which crystallized in the cubic system, space group Pa (3) over bar. The iron center, chelated by the oxygen atoms of the ligand, shows an almost perfect octahedral geometry, with the CN groups disposed at 120 degrees each other. Further reaction with AgClO4 provided the heterometallic coordination polymer (infinity)(2) {[(Fe (bphosCN)(3))(3)Ag-3(H2O)(2)]center dot(ClO4)(3)} 3 as the unique crystalline polymorph, in the monoclinic space group P21/a. The targeted 2D honeycomb type structure has been achieved through an interplay between coordinative CN-Ag bonds and CN center dot center dot center dot H2O bonds. The magnetic measurements demonstrate the existence of isolated paramagnetic Fe(III) centers in both complexes

Load case characterization for the aircraft structural design process

Since aircraft undergo countless ground and flight scenarios during their service life, a large volume of global load cases must be analyzed in a Global Finite Element Model (GFEM) to identify the structural load paths and internal load distributions. Analyzing all load cases is not possible due to computational constraints, so that substantial engineering judgement in load case down-selection is required. An approach is proposed to reduce the number of load cases analyzed by using Singular Value Decomposition (SVD) to derive a smaller set of characteristic loads which approximates all the global load distributions. Herein robust error quantification methods are also proposed to allow the definition of the characteristic loads to a targeted accuracy level, so that the calculation of structural failure can also be evaluated with a known precision. The major downstream benefit of the process is that the analysis results for this set of characteristic loads can be superimposed to create the internal load distributions resulting from all the original load cases, with known accuracy. For realistic design and load data, internal loads need to only be calculated for a few tens of characteristic loads rather than thousands of real load cases

Statin utilization and lipid goal attainment in high or very-high cardiovascular risk patients: Insights from Italian general practice

Background and aims: Statin utilization and lipid goal achievement were estimated in a large sample of Italian patients at high/very-high cardiovascular (CV) risk. Methods: Patients aged â¥18 years with a valid low-density lipoprotein cholesterol (LDL-C) measurement in 2015 were selected from the IMS Health Real World Data database; non-high-density lipoprotein cholesterol (non-HDL-C) was assessed in those with available total cholesterol measurements. Index dates were defined as the last valid lipid measurement in 2015. Patients were hierarchically classified into mutually exclusive risk categories: heterozygous familial hypercholesterolemia (primary and secondary prevention), atherosclerotic CV disease (including recent acute coronary syndrome [ACS], chronic coronary heart disease, stroke, and peripheral arterial disease), and diabetes mellitus (DM) alone. Statin and non-statin lipid-modifying therapy (LMT) use, and European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guideline-recommended goal attainment, were assessed. Results: Among 66,158 patients meeting selection criteria, the overall rate of LMT prescriptions was 53.3%, including 7.7% on high-intensity statin therapy. Statin use was highest for recent ACS and lowest for DM alone. LDL-C goal attainment was 16.0% for <1.8 mmol/l and 45.0% for <2.5 mmol/l; 24.3% reached non-HDL-C <2.6 mmol/l and 52.2% were at <3.3 mmol/l. Goal achievement was greatest with high-intensity statin use. Conclusions: Statin use in this cohort was consistent with previous reports in Italian patients at high/very-high CV risk, and low relative to statin use in other European countries. The low rate of ESC/EAS lipid goal attainment observed was consistent with outcomes of other European studies

Natural acidulants from grape

Non–alcoholic products from grape are proposed, as alternative of use for Vitis Labrusca varieties, which actually are not asked in winemaking. A processing direction may be the production of natural acidulants that can substitute chemical organic acids in various foods. The results of investigations prove what technological process was applied in juice making and how vary during ripening the sugars content in relation with total acidity, sugar/acidity ratio in juice Noah and Isabella varieties is determined in dynamic. Organoleptic and more representative physical–chemicals indices were established in acidulants samples. Canned fruits and vegetables which citric and acetic acids were substituted with grape acidulant, were produced in laboratory conditions. It is decided what successful are fruit puree and canned vegetables. Now it works to optimize the production processes

Cyanomethylene-bis(phosphonate)-Based Lanthanide Complexes: Structural, Photophysical, and Magnetic Investigations

10 pagesInternational audienceThe syntheses, structural investigations, magnetic and photophysical properties of a series of 10 lanthanide mononuclear complexes, containing the heteroditopic ligand cyanomethylene-bis(5,5-dimethyl-2-oxo-1,3,2λ5-dioxa-phosphorinane) (L), are described. The crystallographic analyses indicate two structural types: in the first one, [LnIII(L)3(H2O)2]*H2O (Ln = La, Pr, Nd), the metal ions are eight-coordinated within a square antiprism geometry, while the second one, [LnIII(L)3(H2O)]*8H2O (Ln = Sm, Eu, Gd, Tb, Dy, Ho, Er), contains seven-coordinated LnIII ions within distorted monocapped trigonal prisms...

Counterfeiting detection of milk and derivative products

About the appearance on the market of unqualified milk products, within Practical Scientific Institute of Horticulture and Food Technology (Food Technology Directorate) were initiated research and development works to establish counterfeit milk products and detection methods of them. Physico-chemical quality indices of milk were determined with the use of modern instrumental methods: Milco-Scan device (9 indices), gas-liquid chromatography Chrom-5 (7 fatty acids) and analytical ones. In result of the investigation was established the existence of the Republic Moldova market – nonconforming drinking milk and counterfeit, both water dilution method and substitution of lactic fat with vegetable fat (falsification of content). The absence of respective information on the product label is assigned to the category of informational falsification

Paraganglioma of the cauda equina: a tertiary centre experience and scoping review of the current literature.

Cauda equina paragangliomas are rare benign extra-adrenal neuroendocrine tumours arising from the neural crest cells associated with autonomic ganglia. These tumours are often mistaken preoperatively for ependymomas or schwannomas. Patients present with axial or radicular pain with or without neurological deficits. Recurrence, secretory features and length of follow-up are controversial. We conducted a retrospective cohort study of paraganglioma through searching a prospectively maintained histopathology database. Patient demographics, presentation, surgery, complications, recurrence, follow-up and outcome between 2004 and 2016 were studied. The primary aim was to collate and describe the current evidence base for recurrence and secretory features of the tumour. The secondary objective was to report outcome and follow-up strategy. A scoping review was performed in accordance with the PRISMA-ScR Checklist. Ten patients were diagnosed (M:F 7:3) with a mean age of 53.6 ± 5.1 (range 34-71 years). MRI scans revealed intradural lumbar enhancing lesions. All patients had complete microsurgical excisions without adjuvant therapy with no recurrence with a mean follow-up of 5.1 ± 1.4 years. Tumours were attached to the filum terminale. Electron microscopic images demonstrated abundant neurosecretory granules with no evidence of catecholamine production. A total of 620 articles were screened and 65 papers (including ours) combining 121 patients (mean age 48.8 and M:F 71:50) were included. The mean follow-up was 3.48 ± 0.46 (range 0.15-23 years). Back pain was the most common symptom (94%). Cure following surgery was achieved in 93% of the patients whilst 7% had recurrence. Total resection likely results in cure without the need for adjuvant therapy or prolonged follow-up. However, in certain situations, the length of follow-up should be determined by the treating surgeon

Technologie de fabrication et opportunités d’implementation des acidifiants à la production des conserves

It is proposed the grapes acidifier manufacturing technology, a non-alcoholic natural product that manifest superior nutritional advantages for chemical food additives: acidifiers, sweeteners, preservatives widely used in canned. It was researched several modern techniques to increase the yield of the press must - thermal pretreatment, enzymatic fermentation and microwave treatment. It has designed and implemented several pasteurization versions to reduce the heat load on acidifiers grape and the results obtained have proposed a process for optimized thermal treatment. In laboratory conditions was preserved vegetables and fruit, where the traditional recipe containing acetic acid, sugar and salt was substituted by grape acidifiers. It was decided to further optimizing recipes and develop an assortment of canned which will apply this product from grapes