Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a clinical syndrome that has an ever-growing list of potential causes. The transfusion of blood products is often a life-saving therapy, but it can be associated with the development of ALI/ARDS. Transfusion-related ALI is now the leading cause of transfusion-associated fatalities in the United States. Two infectious causes of ALI/ARDS, severe acute respiratory syndrome and H5N1 influenza, have recently emerged and have the potential for pandemic spread. This article discusses the clinical importance, pathogenesis, diagnosis, management, and prevention of these newly recognized causes of respiratory failure

Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury.

Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established. APC has anticoagulant, anti-inflammatory, antiapoptotic, and profibrinolytic properties, but it is not clear through which of these mechanisms APC exerts its benefit in severe sepsis. Focus has recently turned to the role of APC in maintaining endothelial barrier function, and in vitro and in vivo studies have examined this relationship. This article critically reviews these studies, with a focus on potential mechanisms of action

Reforming the Rentier State: The Imperatives for Change in the Gulf

Chapter

Two Bipolar Outflows and Magnetic Fields in a Multiple Protostar System, L1448 IRS 3

We performed spectral line observations of CO J=2-1, 13CO J=1-0, and C18O J=1-0 and polarimetric observations in the 1.3 mm continuum and CO J=2-1 toward a multiple protostar system, L1448 IRS 3, in the Perseus molecular complex at a distance of ~250 pc, using the BIMA array. In the 1.3 mm continuum, two sources (IRS 3A and 3B) were clearly detected with estimated envelope masses of 0.21 and 1.15 solar masses, and one source (IRS 3C) was marginally detected with an upper mass limit of 0.03 solar masses. In CO J=2-1, we revealed two outflows originating from IRS 3A and 3B. The masses, mean number densities, momentums, and kinetic energies of outflow lobes were estimated. Based on those estimates and outflow features, we concluded that the two outflows are interacting and that the IRS 3A outflow is nearly perpendicular to the line of sight. In addition, we estimated the velocity, inclination, and opening of the IRS 3B outflow using Bayesian statistics. When the opening angle is ~20 arcdeg, we constrain the velocity to ~45 km/s and the inclination angle to ~57 arcdeg. Linear polarization was detected in both the 1.3 mm continuum and CO J=2-1. The linear polarization in the continuum shows a magnetic field at the central source (IRS 3B) perpendicular to the outflow direction, and the linear polarization in the CO J=2-1 was detected in the outflow regions, parallel or perpendicular to the outflow direction. Moreover, we comprehensively discuss whether the binary system of IRS 3A and 3B is gravitationally bound, based on the velocity differences detected in 13CO J=1-0 and C18O J=1-0 observations and on the outflow features. The specific angular momentum of the system was estimated as ~3e20 cm^2/s, comparable to the values obtained from previous studies on binaries and molecular clouds in Taurus.Comment: ApJ accepted, 20 pages, 2 tables, 10 figure

A Flattened Protostellar Envelope in Absorption around L1157

Deep Spitzer IRAC images of L1157 reveal many of the details of the outflow and the circumstellar environment of this Class 0 protostar. In IRAC band 4, 8 microns, there is a flattened structure seen in absorption against the background emission. The structure is perpendicular to the outflow and is extended to a diameter of 2 arcminutes. This structure is the first clear detection of a flattened circumstellar envelope or pseudo-disk around a Class 0 protostar. Such a flattened morphology is an expected outcome for many collapse theories that include magnetic fields or rotation. We construct an extinction model for a power-law density profile, but we do not constrain the density power-law index.Comment: ApJL accepte

Prerequisites for Successful Fiscal Reform: Some Preliminary Results

Journal of Public Budgeting, Accounting and Financial Management, Winter 1998.Refereed Journal ArticleThis paper examines whether any relationship exists between success or failure of policy reform on the one hand, and various political/economic conditions in place at the time of reform on the other. Nineteen countries were scored using three financial variables to measure the degree of success or failure of the reform. The independent variables were country scores for ten different economic and political conditions. The independent variables were used to try and predict a priori which of the nineteen countries would succeed and which would fail. Eighteen of the nineteen countries were correctly placed into their respective success group. However only three of the ten conditions appeared important in predicting success: a visionary leader, a crisis, and a comprehensive program. Other writers have suggested different sets of predicting variables

Testing Magnetic Field Models for the Class 0 Protostar L1527

For the Class 0 protostar, L1527, we compare 131 polarization vectors from SCUPOL/JCMT, SHARP/CSO and TADPOL/CARMA observations with the corresponding model polarization vectors of four ideal-MHD, non-turbulent, cloud core collapse models. These four models differ by their initial magnetic fields before collapse; two initially have aligned fields (strong and weak) and two initially have orthogonal fields (strong and weak) with respect to the rotation axis of the L1527 core. Only the initial weak orthogonal field model produces the observed circumstellar disk within L1527. This is a characteristic of nearly all ideal-MHD, non-turbulent, core collapse models. In this paper we test whether this weak orthogonal model also has the best agreement between its magnetic field structure and that inferred from the polarimetry observations of L1527. We found that this is not the case; based on the polarimetry observations the most favored model of the four is the weak aligned model. However, this model does not produce a circumstellar disk, so our result implies that a non-turbulent, ideal-MHD global collapse model probably does not represent the core collapse that has occurred in L1527. Our study also illustrates the importance of using polarization vectors covering a large area of a cloud core to determine the initial magnetic field orientation before collapse; the inner core magnetic field structure can be highly altered by a collapse and so measurements from this region alone can give unreliable estimates of the initial field configuration before collapse.Comment: 43 pages, 9 figures, 4 tables. Accepted by the Astrophysical Journa

Dense Molecular Gas In A Young Cluster Around MWC 1080 -- Rule Of The Massive Star

We present CS $J = 2 \to 1$, $^{13}$CO $J = 1 \to 0$, and C$^{18}$O $J = 1 \to 0$, observations with the 10-element Berkeley Illinois Maryland Association (BIMA) Array toward the young cluster around the Be star MWC 1080. These observations reveal a biconical outflow cavity with size $\sim$ 0.3 and 0.05 pc for the semimajor and semiminor axis and $\sim$ 45\arcdeg position angle. These transitions trace the dense gas, which is likely the swept-up gas of the outflow cavity, rather than the remaining natal gas or the outflow gas. The gas is clumpy; thirty-two clumps are identified. The identified clumps are approximately gravitationally bound and consistent with a standard isothermal sphere density, which suggests that they are likely collapsing protostellar cores. The gas kinematics suggests that there exists velocity gradients implying effects from the inclination of the cavity and MWC 1080. The kinematics of dense gas has also been affected by either outflows or stellar winds from MWC 1080, and lower-mass clumps are possibly under stronger effects from MWC 1080 than higher-mass clumps. In addition, low-mass cluster members tend to be formed in the denser and more turbulent cores, compared to isolated low-mass star-forming cores. This results from contributions of nearby forming massive stars, such as outflows or stellar winds. Therefore, we conclude that in clusters like the MWC 1080 system, effects from massive stars dominate the star-forming environment in both the kinematics and dynamics of the natal cloud and the formation of low-mass cluster members. This study provides insights into the effects of MWC 1080 on its natal cloud, and suggests a different low-mass star forming environment in clusters compared to isolated star formation.Comment: 42 pages, 5 tables, and 13 figures, accepted for publication in Ap