5,710 research outputs found
On the existence of traveling waves in the 3D Boussinesq system
We extend earlier work on traveling waves in premixed flames in a
gravitationally stratified medium, subject to the Boussinesq approximation. For
three-dimensional channels not aligned with the gravity direction and under the
Dirichlet boundary conditions in the fluid velocity, it is shown that a
non-planar traveling wave, corresponding to a non-zero reaction, exists, under
an explicit condition relating the geometry of the crossection of the channel
to the magnitude of the Prandtl and Rayleigh numbers, or when the advection
term in the flow equations is neglected.Comment: 15 pages, to appear in Communications in Mathematical Physic
Global existence of solutions for the relativistic Boltzmann equation with arbitrarily large initial data on a Bianchi type I space-time
We prove, for the relativistic Boltzmann equation on a Bianchi type I
space-time, a global existence and uniqueness theorem, for arbitrarily large
initial data.Comment: 17 page
Multirelational Organization of Large-scale Social Networks in an Online World
The capacity to collect fingerprints of individuals in online media has
revolutionized the way researchers explore human society. Social systems can be
seen as a non-linear superposition of a multitude of complex social networks,
where nodes represent individuals and links capture a variety of different
social relations. Much emphasis has been put on the network topology of social
interactions, however, the multi-dimensional nature of these interactions has
largely been ignored in empirical studies, mostly because of lack of data.
Here, for the first time, we analyze a complete, multi-relational, large social
network of a society consisting of the 300,000 odd players of a massive
multiplayer online game. We extract networks of six different types of
one-to-one interactions between the players. Three of them carry a positive
connotation (friendship, communication, trade), three a negative (enmity, armed
aggression, punishment). We first analyze these types of networks as separate
entities and find that negative interactions differ from positive interactions
by their lower reciprocity, weaker clustering and fatter-tail degree
distribution. We then proceed to explore how the inter-dependence of different
network types determines the organization of the social system. In particular
we study correlations and overlap between different types of links and
demonstrate the tendency of individuals to play different roles in different
networks. As a demonstration of the power of the approach we present the first
empirical large-scale verification of the long-standing structural balance
theory, by focusing on the specific multiplex network of friendship and enmity
relations.Comment: 7 pages, 5 figures, accepted for publication in PNA
Magneto-transport study of nb-doped Bi/Pb2223 superconductor
The magneto-transport properties of Bi1.5Pb0.4Nb0.1Sr2Ca2Cu3O10-x polycrystalline, superconducting ceramic are reported. The material was found to be chemically homogeneous and partially textured. The mixed state properties were investigated by measuring the electrical resistivity, longitudinal and transverse (Nernst effect) thermoelectric power, and thermal conductivity. The magnetization and AC susceptibility measurements were also performed. The variation of these characteristics for magnetic fields up to 5 T are discussed and compared to those of the zero field case. The transport entropy and thermal Hall angle are extracted and quantitatively compared to previously reported data of closely related systems. (C) 2003 Elsevier Science B.V. All rights reserved
JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.
Background: cJun terminal kinase (JNK) is constitutively
activated in most hepatocellular carcinomas (HCCs), yet
its exact role in carcinogenesis remains controversial.
While tumour necrosis factor (TNF)-related apoptosisinducing
ligand (TRAIL) is known as a major mediator of
acquired immune tumour surveillance, and is currently
being tested in clinical trials as a novel cancer therapy,
the resistance of many tumours to TRAIL and concerns
about its toxicity in vivo represent obstacles to its clinical
application. In this study we investigated whether JNK
activity in HCC could contribute to the resistance to
apoptosis in these tumours.
Methods: The effect of JNK/Jun inhibition on receptormediated
apoptosis was analysed by pharmacological
inhibition or RNA interference in cancer cells and nontumour
cells isolated from human liver or transgenic mice
lacking a phosphorylation site for Jun.
Results: JNK inhibition caused cell cycle arrest,
enhanced caspase recruitment, and greatly sensitised
HCC cells but not normal hepatocytes to TRAIL. TRAILinduced
activation of JNK could be effectively interrupted
by administration of the JNK inhibitor SP600125.
Conclusions: Expression and TRAIL-dependent feedback
activation of JNK likely represent a mechanism by which
cancer cells escape TRAIL-mediated tumour surveillance.
JNK inhibition might represent a novel strategy for
specifically sensitising HCC cells to TRAIL thus opening
promising therapeutic perspectives for safe and effective
use of TRAIL in cancer treatment
Directional approach to spatial structure of solutions to the Navier-Stokes equations in the plane
We investigate a steady flow of incompressible fluid in the plane. The motion
is governed by the Navier-Stokes equations with prescribed velocity
at infinity. The main result shows the existence of unique solutions for
arbitrary force, provided sufficient largeness of . Furthermore a
spacial structure of the solution is obtained in comparison with the Oseen
flow. A key element of our new approach is based on a setting which treats the
directino of the flow as \emph{time} direction. The analysis is done in
framework of the Fourier transform taken in one (perpendicular) direction and a
special choice of function spaces which take into account the inhomogeneous
character of the symbol of the Oseen system. From that point of view our
technique can be used as an effective tool in examining spatial asymptotics of
solutions to other systems modeled by elliptic equations
Role of social environment and social clustering in spread of opinions in co-evolving networks
Taking a pragmatic approach to the processes involved in the phenomena of
collective opinion formation, we investigate two specific modifications to the
co-evolving network voter model of opinion formation, studied by Holme and
Newman [1]. First, we replace the rewiring probability parameter by a
distribution of probability of accepting or rejecting opinions between
individuals, accounting for the asymmetric influences in relationships among
individuals in a social group. Second, we modify the rewiring step by a
path-length-based preference for rewiring that reinforces local clustering. We
have investigated the influences of these modifications on the outcomes of the
simulations of this model. We found that varying the shape of the distribution
of probability of accepting or rejecting opinions can lead to the emergence of
two qualitatively distinct final states, one having several isolated connected
components each in internal consensus leading to the existence of diverse set
of opinions and the other having one single dominant connected component with
each node within it having the same opinion. Furthermore, and more importantly,
we found that the initial clustering in network can also induce similar
transitions. Our investigation also brings forward that these transitions are
governed by a weak and complex dependence on system size. We found that the
networks in the final states of the model have rich structural properties
including the small world property for some parameter regimes. [1] P. Holme and
M. Newman, Phys. Rev. E 74, 056108 (2006)
Coexistence of opposite opinions in a network with communities
The Majority Rule is applied to a topology that consists of two coupled
random networks, thereby mimicking the modular structure observed in social
networks. We calculate analytically the asymptotic behaviour of the model and
derive a phase diagram that depends on the frequency of random opinion flips
and on the inter-connectivity between the two communities. It is shown that
three regimes may take place: a disordered regime, where no collective
phenomena takes place; a symmetric regime, where the nodes in both communities
reach the same average opinion; an asymmetric regime, where the nodes in each
community reach an opposite average opinion. The transition from the asymmetric
regime to the symmetric regime is shown to be discontinuous.Comment: 14 pages, 4 figure
Graph Metrics for Temporal Networks
Temporal networks, i.e., networks in which the interactions among a set of
elementary units change over time, can be modelled in terms of time-varying
graphs, which are time-ordered sequences of graphs over a set of nodes. In such
graphs, the concepts of node adjacency and reachability crucially depend on the
exact temporal ordering of the links. Consequently, all the concepts and
metrics proposed and used for the characterisation of static complex networks
have to be redefined or appropriately extended to time-varying graphs, in order
to take into account the effects of time ordering on causality. In this chapter
we discuss how to represent temporal networks and we review the definitions of
walks, paths, connectedness and connected components valid for graphs in which
the links fluctuate over time. We then focus on temporal node-node distance,
and we discuss how to characterise link persistence and the temporal
small-world behaviour in this class of networks. Finally, we discuss the
extension of classic centrality measures, including closeness, betweenness and
spectral centrality, to the case of time-varying graphs, and we review the work
on temporal motifs analysis and the definition of modularity for temporal
graphs.Comment: 26 pages, 5 figures, Chapter in Temporal Networks (Petter Holme and
Jari Saram\"aki editors). Springer. Berlin, Heidelberg 201
Anomalous thermoelectric power of Mg1-xAlxB2 system with x = 0.0 to 1.0
Thermoelectric power, S(T) of the Mg1-xAlxB2 system has been measured for x =
0.0, 0.1, 0.2, 0.4, 0.6, 0.8 and 1.0. XRD, resistivity and magnetization
measurements are also presented. It has been found that the thermoelectric
power is positive for x = 0.4 and is negative for x = 0.6 over the entire
temperature range studied up to 300 K. The thermoelectric power of x = 0.4
samples vanishes discontinuously below a certain temperature, implying
existence of superconductivity. In general, the magnitude of the thermoelectric
power increases with temperature up to a certain temperature, and then it
starts to decrease towards zero base line. In order to explain the observed
behavior of the thermoelectric power, we have used a model in which both
diffusion and phonon drag processes are combined by using a phenomenological
interpolation between the low and high temperature behaviors of the
thermoelectric power. The considered model provides an excellent fit to the
observed data. It is further found that Al doping enhances the Debye
temperature.Comment: 19 pages Text + Figs.
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