Moxifloxacin-induced tinnitus in an older adult

An increased risk of bacterial resistance toward fluoroquinolones and the increased risk of disabling and serious adverse effects prompted the US Food and Drug Administration to recommend limiting fluoroquinolone use to the treatment of community-acquired pneumonia, skin and skin-structure infections, bacterial sinusitis, plague, chronic bronchitis exacerbations, and complicated intra-abdominal infections. We report a case of moxifloxacin-induced tinnitus in an older adult prescribed oral moxifloxacin 400 mg for 5 days for the treatment of acute diverticulitis, due to allergies to nonfluoroquinolone preferred agents. A thorough literature review provided few other reported incidents of this rare and serious adverse event. </jats:p

Predictors of anemia in pregnancy among pregnant women accessing antenatal care in a poor resource setting in South Eastern Nigeria

Background: Anemia in pregnancy affects about half of pregnant women and constitutes a serious health problem. Objectives: The aim was to determine the prevalence of anemia in pregnancy, as well as its pattern and determinants. Materials and Methods: This was a prospective cross-sectional study conducted at antenatal booking clinic of Federal Teaching Hospital Abakaliki from February to July 2012. Hemoglobin <11 g/dl was regarded as anemia. Estimation of hemoglobin concentration, HIV infection, blood group, genotype and blood film for malaria parasite and erythrocyte morphology were done. Stool analysis was also done. Results: Prevalence of anemia in pregnancy was 58%. Anemia in pregnancy was a common finding among primigravida 82 (66.1%), social Class II 14 (56.0%), social Class III 98 (53.6%), social Class IV 45 (61.6%), social Class V 117 (65.4%), antenatal booking at 14–27 weeks 211 (70.3%), and antenatal booking at ≥28 weeks 47 (74.6%). The significant predictors of anemia in pregnancy include HIV in pregnancy (odds ratio [OR] =4.88 [1.09–21.84]), P = 0.04, obstetric hemorrhage (OR = 2.97 [1.27–6.97]), P = 0.01, malaria parasitemia (OR = 4.28 [2.28–8.03]), P < 0.001, primigravidity (OR = 0.04 [1.03–2.41]), P = 0.04, and helminthiasis (P < 0.001). Conclusion: Anemia is still a common finding in pregnancy, and important contributing factors include malaria parasitemia, helminthic infestation and HIV in pregnancy

Magnitude and Pattern of Disease Presentation among Students in Federal University of Technology Owerri Nigeria 1*

Abstract: Students&apos; wellbeing is paramount to their effective participation in academic and extracurricular activities. This study described the prevalence and pattern of disease presentation among students attending Federal University of Technology Medical Centre, Owerri, Nigeria. A descriptive cross-sectional hospital based study of consecutive 552 students who gave their informed consent. Data were extracted through clerking, examination and laboratory investigations and they included socio-demographic information and diagnoses. These data were entered into Microsoft Excel 2016 and transported to Xlstat 2015 for analysis. The age distribution of the students revealed that majority of the students (46.4%) were within the age bracket of 17-23years. The mean age of the students was 24 years. The majority of the students (22.6%) were drawn from the School of Engineering and Engineering Technology. The disease pattern of students showed that typhomalaria fever was most prevalent (33.5%), malaria (28.9%), upper respiratory tract infection (21.3%), hypertension (7.3%), peptic ulcer disease (5.7%) and typhoid (3.6%). Malaria was most prevalent during the rainy season in the months of June and July, 36.5% and 35.1% respectively. Strengthening of the primary health care system, application of the principles of integrated vector management and investing substantially in specialist care model will lessen the burden of diseases in the University community