A mathematical framework for combining decisions of multiple experts toward accurate and remote diagnosis of malaria using tele-microscopy.

We propose a methodology for digitally fusing diagnostic decisions made by multiple medical experts in order to improve accuracy of diagnosis. Toward this goal, we report an experimental study involving nine experts, where each one was given more than 8,000 digital microscopic images of individual human red blood cells and asked to identify malaria infected cells. The results of this experiment reveal that even highly trained medical experts are not always self-consistent in their diagnostic decisions and that there exists a fair level of disagreement among experts, even for binary decisions (i.e., infected vs. uninfected). To tackle this general medical diagnosis problem, we propose a probabilistic algorithm to fuse the decisions made by trained medical experts to robustly achieve higher levels of accuracy when compared to individual experts making such decisions. By modelling the decisions of experts as a three component mixture model and solving for the underlying parameters using the Expectation Maximisation algorithm, we demonstrate the efficacy of our approach which significantly improves the overall diagnostic accuracy of malaria infected cells. Additionally, we present a mathematical framework for performing 'slide-level' diagnosis by using individual 'cell-level' diagnosis data, shedding more light on the statistical rules that should govern the routine practice in examination of e.g., thin blood smear samples. This framework could be generalized for various other tele-pathology needs, and can be used by trained experts within an efficient tele-medicine platform

Static index pruning in web search engines: Combining term and document popularities with query views

Cataloged from PDF version of article.Static index pruning techniques permanently remove a presumably redundant part of an inverted file, to reduce the file size and query processing time. These techniques differ in deciding which parts of an index can be removed safely; that is, without changing the top-ranked query results. As defined in the literature, the query view of a document is the set of query terms that access to this particular document, that is, retrieves this document among its top results. In this paper, we first propose using query views to improve the quality of the top results compared against the original results. We incorporate query views in a number of static pruning strategies, namely term-centric, document-centric, term popularity based and document access popularity based approaches, and show that the new strategies considerably outperform their counterparts especially for the higher levels of pruning and for both disjunctive and conjunctive query processing. Additionally, we combine the notions of term and document access popularity to form new pruning strategies, and further extend these strategies with the query views. The new strategies improve the result quality especially for the conjunctive query processing, which is the default and most common search mode of a search engine

Possible Single Resonant Production of the Fourth Generation Charged Leptons at γe\gamma e Colliders

Single resonant productions of the fourth standard model generation charged lepton via anomalous interactions at gamma e colliders based on future linear e^+ e^- colliders with 500 GeV and 1 TeV center of mass energies are studied. Signatures of $\gamma e\to \ell_4\to e\gamma$ and $\gamma e\to \ell_4\to eZ$ anomalous processes followed by the hadronic and leptonic decay of the Z boson and corresponding standard model backgrounds are discussed in details. The lowest necessary luminosities to observe these processes and the achievable values of the anomalous coupling strengths are determined.Comment: 9 pages, 6 figures, 4 table

Gas-liquid mass transfer : a comparison of down-and up-pumping axial flow impellers with radial impellers

The performance of a down- and up-pumping pitched blade turbine and A315 for gas-liquid dispersion and mass transfer was evaluated and then compared with that of Rushton and Scaba turbines in a small laboratory scale vessel. The results show that when the axial flow impellers are operated in the up-pumping mode, the overall performance is largely improved compared with the down-pumping configuration. Compared with the radial turbines, the up-pumping A315 has a high gas handling capacity, equivalent to the Scaba turbine and is economically much more efficient in terms of mass transfer than both turbines. On the other hand, the uppumping pitched blade turbine is not as well adapted to such applications. Finally, the axial flow impellers in the down-pumping mode have the lowest performance of all the impellers studied, although the A315 is preferred of the pitched blade turbine

Corrosion Resistance Studies of Austenitic Stainless Steel Grades in Molten Zinc-Aluminum Alloy Galvanizing Bath

The corrosion inhibition performance and mechanical behavior of galvanized and heat-treated four newly developed austenitic stainless steel grades and type 316L austenitic stainless steel for application as sink rolls in galvanizing baths of 0.14–0.21 wt.% aluminum was investigated and compared through immersion corrosion test to determine the weight loss between 168 and 504 h, tensile test, and Charpy impact test. The delta ferrite content of the test samples was observed and estimated through optical microscopy, feritscope, and ONRL diagram. Scanning electron microscopy and energy dispersive spectroscopy were used to characterize the surface microstructure, morphology, and chemical composition of the galvanized coating of the steel samples. Result showed that only two of the newly developed stainless steel compositions were selected for use in fabrication of galvanizing hardware based on the comparisons of corrosion and mechanical performances of tested alloy

High-throughput screening of encapsulated islets using wide-field lens-free on-chip imaging

Islet microencapsulation is a promising solution to diabetes treatment, but its quality control based on manual microscopic inspection is extremely low-throughput, highly variable and laborious. This study presents a high-throughput islet-encapsulation quality screening system based on lens-free on-chip imaging with a wide field-of-view of 18.15 cm^2, which is more than 100 times larger than that of a lens-based optical microscope, enabling it to image and analyze ~8,000 microcapsules in a single frame. Custom-written image reconstruction and processing software provides the user with clinically important information, such as microcapsule count, size, intactness, and information on whether each capsule contains an islet. This high-throughput and cost-effective platform can be useful for researchers to develop better encapsulation protocols as well as perform quality control prior to transplantation

Negative magnetocaloric effect from highly sensitive metamagnetism in CoMnSi_{1-x}Ge_{x}

We report a novel negative magnetocaloric effect in CoMnSi_{1-x}Ge_{x} arising from a metamagnetic magnetoelastic transition. The effect is of relevance to magnetic refrigeration over a wide range of temperature, including room temperature. In addition we report a very high shift in the metamagnetic transition temperature with applied magnetic field. This is driven by competition between antiferromagnetic and ferromagnetic order which can be readily tuned by applied pressure and compositional changes.Comment: 5 pages, 5 figures, REVTeX, submitted to Physical Revie