A Bethe--Salpeter Description of Light Mesons

We present a covariant approach to describe the low--lying scalar, pseudoscalar, vector and axialvector mesons as quark--antiquark bound states.This approach is based on an effective interaction modeling of the non--perturbative structure of the gluon propagator that enters the quark Schwinger--Dyson and meson Bethe--Salpeter equations. We extract the meson masses and compute the pion and kaon decay constants. We obtain a quantitatively correct description for pions, kaons and vector mesons while the calculated spectra of scalar and axialvector mesons suggest that their structure is more complex than being quark--antiquark bound states.Comment: Talk presented by HW at the international Scalar Meson Workshop, Utica, NY, May 2003; 12 pages, uses aip style file

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3

Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human platelet activation by E. coli leading to thrombus formation are poorly understood. While the IgG receptor FcγRIIA has a key role in platelet response to various Gram-positive species, its role in activation to Gram-negative bacteria is poorly defined. This study aimed to investigate the molecular mechanisms of human platelet activation by E. coli, including the potential role of FcγRIIA. Using light-transmission aggregometry, measurements of ATP release and tyrosine-phosphorylation, we investigated the ability of two E. coli clinical isolates to activate platelets in plasma, in the presence or absence of specific receptors and signaling inhibitors. Aggregation assays with washed platelets supplemented with IgGs were performed to evaluate the requirement of this plasma component in activation. We found a critical role for the immune receptor FcγRIIA, αIIbβ3, and Src and Syk tyrosine kinases in platelet activation in response to E. coli. IgG and αIIbβ3 engagement was required for FcγRIIA activation. Moreover, feedback mediators adenosine 5’-diphosphate (ADP) and thromboxane A₂ (TxA₂) were essential for platelet aggregation. These findings suggest that human platelet responses to E. coli isolates are similar to those induced by Gram-positive organisms. Our observations support the existence of a central FcγRIIA-mediated pathway by which human platelets respond to both Gram-negative and Gram-positive bacteria

Microscopic resolution broadband dielectric spectroscopy

Results are presented for a non-contact measurement system capable of micron level spatial resolution. It utilises the novel electric potential sensor (EPS) technology, invented at Sussex, to image the electric field above a simple composite dielectric material. EP sensors may be regarded as analogous to a magnetometer and require no adjustments or offsets during either setup or use. The sample consists of a standard glass/epoxy FR4 circuit board, with linear defects machined into the surface by a PCB milling machine. The sample is excited with an a.c. signal over a range of frequencies from 10 kHz to 10 MHz, from the reverse side, by placing it on a conducting sheet connected to the source. The single sensor is raster scanned over the surface at a constant working distance, consistent with the spatial resolution, in order to build up an image of the electric field, with respect to the reference potential. The results demonstrate that both the surface defects and the internal dielectric variations within the composite may be imaged in this way, with good contrast being observed between the glass mat and the epoxy resin

The shape of primordial non-Gaussianity and the CMB bispectrum

We present a set of formalisms for comparing, evolving and constraining primordial non-Gaussian models through the CMB bispectrum. We describe improved methods for efficient computation of the full CMB bispectrum for any general (non-separable) primordial bispectrum, incorporating a flat sky approximation and a new cubic interpolation. We review all the primordial non-Gaussian models in the present literature and calculate the CMB bispectrum up to l <2000 for each different model. This allows us to determine the observational independence of these models by calculating the cross-correlation of their CMB bispectra. We are able to identify several distinct classes of primordial shapes - including equilateral, local, warm, flat and feature (non-scale invariant) - which should be distinguishable given a significant detection of CMB non-Gaussianity. We demonstrate that a simple shape correlator provides a fast and reliable method for determining whether or not CMB shapes are well correlated. We use an eigenmode decomposition of the primordial shape to characterise and understand model independence. Finally, we advocate a standardised normalisation method for $f_{NL}$ based on the shape autocorrelator, so that observational limits and errors can be consistently compared for different models.Comment: 32 pages, 20 figure

Aspects of the confinement mechanism in Coulomb-gauge QCD

Phenomenological consequences of the infrared singular, instantaneous part of the gluon propagator in Coulomb gauge are investigated. The corresponding quark Dyson-Schwinger equation is solved, neglecting retardation and transverse gluons and regulating the resulting infrared singularities. While the quark propagator vanishes as the infrared regulator goes to zero, the frequency integral over the quark propagator stays finite and well-defined. Solutions of the homogeneous Bethe-Salpeter equation for the pseudoscalar and vector mesons as well as for scalar and axial-vector diquarks are obtained. In the limit of a vanishing infrared regulator the diquark masses diverge, while meson properties and diquark radii remain finite and well-defined. These features are interpreted with respect to the resulting aspects of confinement for colored quark-quark correlations.Comment: 4 pages, 6 figure

Primordial non-Gaussianity and the CMB bispectrum

We present a new formalism, together with efficient numerical methods, to directly calculate the CMB bispectrum today from a given primordial bispectrum using the full linear radiation transfer functions. Unlike previous analyses which have assumed simple separable ansatze for the bispectrum, this work applies to a primordial bispectrum of almost arbitrary functional form, for which there may have been both horizon-crossing and superhorizon contributions. We employ adaptive methods on a hierarchical triangular grid and we establish their accuracy by direct comparison with an exact analytic solution, valid on large angular scales. We demonstrate that we can calculate the full CMB bispectrum to greater than 1% precision out to multipoles l<1800 on reasonable computational timescales. We plot the bispectrum for both the superhorizon ('local') and horizon-crossing ('equilateral') asymptotic limits, illustrating its oscillatory nature which is analogous to the CMB power spectrum

The Glasgow Voice Memory Test: Assessing the ability to memorize and recognize unfamiliar voices

One thousand one hundred and twenty subjects as well as a developmental phonagnosic subject (KH) along with age-matched controls performed the Glasgow Voice Memory Test, which assesses the ability to encode and immediately recognize, through an old/new judgment, both unfamiliar voices (delivered as vowels, making language requirements minimal) and bell sounds. The inclusion of non-vocal stimuli allows the detection of significant dissociations between the two categories (vocal vs. non-vocal stimuli). The distributions of accuracy and sensitivity scores (d’) reflected a wide range of individual differences in voice recognition performance in the population. As expected, KH showed a dissociation between the recognition of voices and bell sounds, her performance being significantly poorer than matched controls for voices but not for bells. By providing normative data of a large sample and by testing a developmental phonagnosic subject, we demonstrated that the Glasgow Voice Memory Test, available online and accessible from all over the world, can be a valid screening tool (~5 min) for a preliminary detection of potential cases of phonagnosia and of “super recognizers” for voices

Gravitational wave energy spectrum of a parabolic encounter

We derive an analytic expression for the energy spectrum of gravitational waves from a parabolic Keplerian binary by taking the limit of the Peters and Matthews spectrum for eccentric orbits. This demonstrates that the location of the peak of the energy spectrum depends primarily on the orbital periapse rather than the eccentricity. We compare this weak-field result to strong-field calculations and find it is reasonably accurate (~10%) provided that the azimuthal and radial orbital frequencies do not differ by more than ~10%. For equatorial orbits in the Kerr spacetime, this corresponds to periapse radii of rp > 20M. These results can be used to model radiation bursts from compact objects on highly eccentric orbits about massive black holes in the local Universe, which could be detected by LISA.Comment: 5 pages, 3 figures. Minor changes to match published version; figure 1 corrected; references adde

Gamma-Ray Bursts observed by XMM-Newton

Analysis of observations with XMM-Newton have made a significant contribution to the study of Gamma-ray Burst (GRB) X-ray afterglows. The effective area, bandpass and resolution of the EPIC instrument permit the study of a wide variety of spectral features. In particular, strong, time-dependent, soft X-ray emission lines have been discovered in some bursts. The emission mechanism and energy source for these lines pose major problems for the current generation of GRB models. Other GRBs have intrinsic absorption, possibly related to the environment around the progenitor, or possible iron emission lines similar to those seen in GRBs observed with BeppoSAX. Further XMM-Newton observations of GRBs discovered by the Swift satellite should help unlock the origin of the GRB phenomenon over the next few years.Comment: To appear in proceedings of the "XMM-Newton EPIC Consortium meeting, Palermo, 2003 October 14-16", published in Memorie della Societa Astronomica Italian