Gestion durable du paysage : les leçons que les nouveaux parcs naturels régionaux doivent tirer de l'expérience des anciennes corporations

The landscape is increasingly perceived as a resource. For this reason, it is necessary to find legal, political and economic instruments that will succeed in managing this “resource landscape” in the long term. The Swiss government recently introduced the instrument of regional nature parks into the legislation governing nature and landscape preservation; the proposed parks are organized on the basis of the French model. The examination of the new parks from the perspective of much older management structures, i.e. the civic municipalities (bourgeoisies) and corporations, makes it possible to demonstrate the strengths and weaknesses of each of these instruments in their contribution to the resolution of use rivalries between actors who use or influence the resource landscape. This comparison also enables the formulation of practical recommendations regarding the management of this resource

Dendritic flux penetration in Pb films with a periodic array of antidots

We explore the flux-jump regime in type-II Pb thin films with a periodic array of antidots by means of magneto-optical measurements. A direct visualization of the magnetic flux distribution allows to identify a rich morphology of flux penetration patterns. We determine the phase boundary $H^*(T)$ between dendritic penetration at low temperatures and a smooth flux invasion at high temperatures and fields. For the whole range of fields and temperatures studied, guided vortex motion along the principal axes of the square pinning array is clearly observed. In particular, the branching process of the dendrite expansion is fully governed by the underlying pinning topology. A comparative study between macroscopic techniques and direct local visualization shed light onto the puzzling $T-$ and $H-$independent magnetic response observed at low temperatures and fields. Finally, we find that the distribution of avalanche sizes at low temperatures can be described by a power law with exponent $\tau \sim 0.9(1)$

Magnetic trapping and coherent control of laser-cooled molecules

We demonstrate coherent microwave control of the rotational, hyperfine and Zeeman states of ultracold CaF molecules, and the magnetic trapping of these molecules in a single, selectable quantum state. We trap about $5\times 10^{3}$ molecules for 2 s at a temperature of 65(11) $\mu$K and a density of $1.2 \times 10^{5}$ cm$^{-3}$. We measure the state-specific loss rate due to collisions with background helium.Comment: 6 pages, 4 figure

FcRn-mediated antibody transport across epithelial cells revealed by electron tomography

The neonatal Fc receptor (FcRn) transports maternal IgG across epithelial barriers, thereby providing the fetus or newborn with humoral immunity before its immune system is fully functional. In newborn rats, FcRn transfers IgG from milk to blood by apical-to-basolateral transcytosis across intestinal epithelial cells. The pH difference between the apical (pH 6.0–6.5) and basolateral (pH 7.4) sides of intestinal epithelial cells facilitates the efficient unidirectional transport of IgG, because FcRn binds IgG at pH 6.0–6.5 but not at pH 7 or more. As milk passes through the neonatal intestine, maternal IgG is removed by FcRn-expressing cells in the proximal small intestine (duodenum and jejunum); remaining proteins are absorbed and degraded by FcRn-negative cells in the distal small intestine (ileum). Here we use electron tomography to make jejunal transcytosis visible directly in space and time, developing new labelling and detection methods to map individual nanogold-labelled Fc within transport vesicles and simultaneously to characterize these vesicles by immunolabelling. Combining electron tomography with a nonperturbing endocytic label allowed us to conclusively identify receptor-bound ligands, resolve interconnecting vesicles, determine whether a vesicle was microtubule-associated, and accurately trace FcRn-mediated transport of IgG. Our results present a complex picture in which Fc moves through networks of entangled tubular and irregular vesicles, only some of which are microtubule-associated, as it migrates to the basolateral surface. New features of transcytosis are elucidated, including transport involving multivesicular body inner vesicles/tubules and exocytosis through clathrin-coated pits. Markers for early, late and recycling endosomes each labelled vesicles in different and overlapping morphological classes, revealing spatial complexity in endo-lysosomal trafficking

Receptor-mediated transport of IgG

The intestinal epithelium of the neonatal rat is a model system for the study of receptor-mediated endocytosis in which large amounts of IgG are transferred intact across polarized cells. This review summarizes the ultrastructural pathway followed by IgG during cellular transit and several important properties of the membrane receptor that recognizes the IgG