A novel architecture for a reconfigurable micro machining cell

There is a growing demand for machine tools that are specifically designed for the manufacture of micro-scale components. Such machine tools are integrated into flexible micro-manufacturing systems. Design objectives for such tools include energy efficiency, small footprint and importantly flexibility, with the ability to easily reconfigure the manufacturing system in response to process requirements and product demands. Such systems find application in medical, photonics, automotive and electronic industries. In this paper, a new architecture for a reconfigurable micro manufacturing system is presented. The proposed architecture comprises a micro manufacturing cell with the key design feature being a hexagonal-base on which three tool heads can be attached to three of its sides. Each such machine-tool head, or processing module, is able to perform a different manufacturing process. These tool heads are interchangeable, enabling the cell to be configured to process a wide range of components with different materials, dimensions, tolerances and specification. Additional components of the cell include manipulation robots and an automated buffer unit. Such cells can be integrated into a manufacturing system via a modular conveyor belt to transfer parts from one cell to another and into assembly. A key consideration of the architecture is a control system that is also modular and reconfigurable; such that when new processing modules are introduced the control system is aware of the change and adjusts accordingly. Further to this coordination, issues between modules and machining cells are also considered. Other design considerations include work-piece holding and manipulation. This paper provides an overview of the architecture, the key design and implementation challenges as well as a high level operational performance assessment by means of a discrete event simulation model of the micro factory cell

Study of microRNAs-21/221 as potential breast cancer biomarkers in Egyptian women

microRNAs (miRNAs) play an important role in cancer prognosis. They are small molecules, approximately 17–25 nucleotides in length, and their high stability in human serum supports their use as novel diagnostic biomarkers of cancer and other pathological conditions. In this study, we analyzed the expression patterns of miR-21 and miR-221 in the serum from a total of 100 Egyptian female subjects with breast cancer, fibroadenoma, and healthy control subjects. Using microarray-based expression profiling followed by real-time polymerase chain reaction validation, we compared the levels of the two circulating miRNAs in the serum of patients with breast cancer (n = 50), fibroadenoma (n = 25), and healthy controls (n = 25). The miRNA SNORD68 was chosen as the housekeeping endogenous control. We found that the serum levels of miR-21 and miR-221 were significantly overexpressed in breast cancer patients compared to normal controls and fibroadenoma patients. Receiver Operating Characteristic (ROC) curve analysis revealed that miR-21 has greater potential in discriminating between breast cancer patients and the control group, while miR-221 has greater potential in discriminating between breast cancer and fibroadenoma patients. Classification models using k-Nearest Neighbor (kNN), Naïve Bayes (NB), and Random Forests (RF) were developed using expression levels of both miR-21 and miR-221. Best classification performance was achieved by NB Classification models, reaching 91% of correct classification. Furthermore, relative miR-221 expression was associated with histological tumor grades. Therefore, it may be concluded that both miR-21 and miR-221 can be used to differentiate between breast cancer patients and healthy controls, but that the diagnostic accuracy of serum miR-21 is superior to miR-221 for breast cancer prediction. miR-221 has more diagnostic power in discriminating between breast cancer and fibroadenoma patients. The overexpression of miR-221 has been associated with the breast cancer grade. We also demonstrated that the combined expression of miR-21 and miR-221can be successfully applied as breast cancer biomarkers

Multi-port, optically addressed RAM

A random access memory addressing system utilizing optical links between memory and the read/write logic circuits comprises addressing circuits including a plurality of light signal sources, a plurality of optical gates including optical detectors associated with the memory cells, and a holographic optical element adapted to reflect and direct the light signals to the desired memory cell locations. More particularly, it is a multi-port, binary computer memory for interfacing with a plurality of computers. There are a plurality of storage cells for containing bits of binary information, the storage cells being disposed at the intersections of a plurality of row conductors and a plurality of column conductors. There is interfacing logic for receiving information from the computers directing access to ones of the storage cells. There are first light sources associated with the interfacing logic for transmitting a first light beam with the access information modulated thereon. First light detectors are associated with the storage cells for receiving the first light beam, for generating an electrical signal containing the access information, and for conducting the electrical signal to the one of the storage cells to which it is directed. There are holographic optical elements for reflecting the first light beam from the first light sources to the first light detectors

Non-Standard Intersections of S-Branes in D=11 Supergravity

We construct new intersecting S-brane solutions in 11-dimensional supergravity which do not have supersymmetric analogs. They are obtained by letting brane charges to be proportional to each other. Solutions fall into two categories with respect to whether there is a non-diagonal term to be cancelled in the field equations or not. In each case we show that they can be constructed by using a simple set of rules which is similar to the harmonic function rule of the usual static p-branes. Furthermore, we study an intersection where the Chern-Simons term makes a non-zero contribution to the field equations. We show that this configuration has a singularity like other S-branes.Comment: 13 pages, 2 figures;v2 Section 2.2 is improved with new examples, references added;v3 typos correcte

Experimental and theoretical investigation of ligand effects on the synthesis of ZnO nanoparticles

ZnO nanoparticles with highly controllable particle sizes(less than 10 nm) were synthesized using organic capping ligands in Zn(Ac)2 ethanolic solution. The molecular structure of the ligands was found to have significant influence on the particle size. The multi-functional molecule tris(hydroxymethyl)-aminomethane (THMA) favoured smaller particle distributions compared with ligands possessing long hydrocarbon chains that are more frequently employed. The adsorption of capping ligands on ZnnOn crystal nuclei (where n = 4 or 18 molecular clusters of(0001) ZnO surfaces) was modelled by ab initio methods at the density functional theory (DFT) level. For the molecules examined, chemisorption proceeded via the formation of Zn...O, Zn...N, or Zn...S chemical bonds between the ligands and active Zn2+ sites on ZnO surfaces. The DFT results indicated that THMA binds more strongly to the ZnO surface than other ligands, suggesting that this molecule is very effective at stabilizing ZnO nanoparticle surfaces. This study, therefore, provides new insight into the correlation between the molecular structure of capping ligands and the morphology of metal oxide nanostructures formed in their presence

Ontology in Holonic Cooperative Manufacturing: A Solution to Share and Exchange the Knowledge

Cooperative manufacturing is a new trend in industry, which depends on the existence of a collaborative robot. A collaborative robot is usually a light-weight robot which is capable of operating safely with a human co-worker in a shared work environment. During this cooperation, a vast amount of information is exchanged between the collaborative robot and the worker. This information constructs the cooperative manufacturing knowledge, which describes the production components and environment. In this research, we propose a holonic control solution, which uses the ontology concept to represent the cooperative manufacturing knowledge. The holonic control solution is implemented as an autonomous multi-agent system that exchanges the manufacturing knowledge based on an ontology model. Ultimately, the research illustrates and implements the proposed solution over a cooperative assembly scenario, which involves two workers and one collaborative robot, whom cooperate together to assemble a customized product

Coding by Design: GPT-4 empowers Agile Model Driven Development

Generating code from a natural language using Large Language Models (LLMs) such as ChatGPT, seems groundbreaking. Yet, with more extensive use, it's evident that this approach has its own limitations. The inherent ambiguity of natural language presents challenges for complex software designs. Accordingly, our research offers an Agile Model-Driven Development (MDD) approach that enhances code auto-generation using OpenAI's GPT-4. Our work emphasizes "Agility" as a significant contribution to the current MDD method, particularly when the model undergoes changes or needs deployment in a different programming language. Thus, we present a case-study showcasing a multi-agent simulation system of an Unmanned Vehicle Fleet. In the first and second layer of our approach, we constructed a textual representation of the case-study using Unified Model Language (UML) diagrams. In the next layer, we introduced two sets of constraints that minimize model ambiguity. Object Constraints Language (OCL) is applied to fine-tune the code constructions details, while FIPA ontology is used to shape communication semantics and protocols. Ultimately, leveraging GPT-4, our last layer auto-generates code in both Java and Python. The Java code is deployed within the JADE framework, while the Python code is deployed in PADE framework. Concluding our research, we engaged in a comprehensive evaluation of the generated code. From a behavioural standpoint, the auto-generated code aligned perfectly with the expected UML sequence diagram. Structurally, we compared the complexity of code derived from UML diagrams constrained solely by OCL to that influenced by both OCL and FIPA-ontology. Results indicate that ontology-constrained model produce inherently more intricate code, but it remains manageable and low-risk for further testing and maintenance

Worker Robot Cooperation and Integration into the Manufacturing Workcell via the Holonic Control Architecture

Worker-Robot Cooperation is a new industrial trend, which aims to sum the advantages of both the human and the industrial robot to afford a new intelligent manufacturing techniques. The cooperative manufacturing between the worker and the robot contains other elements such as the product parts and the manufacturing tools. All these production elements must cooperate in one manufacturing workcell to fulfill the production requirements. The manufacturing control system is the mean to connect all these cooperative elements together in one body. This manufacturing control system is distributed and autonomous due to the nature of the cooperative workcell. Accordingly, this article proposes the holonic control architecture as the manufacturing concept of the cooperative workcell. Furthermore, the article focuses on the feasibility of this manufacturing concept, by applying it over a case study that involves the cooperation between a dual-arm robot and a worker. During this case study, the worker uses a variety of hand gestures to cooperate with the robot to achieve the highest production flexibilit

Fermentative Gas Production of Different Feeds Collected During Wet and Dry Seasons when Incubated with Rumen Fluid from Timor Deer (Cervus timorensis)

An experiment was done to investigate rumen microbial fermentation of various feeds comonly given to Timor deer (Cervus timorensis) using the in vitro gas production technique. Seven forage feed sample (Sesbania grandiflora, Leucaena leucocephala, Glyricidia sepium, Zea mays, Ipomea aquatica, Pennisetum purpureum, and native grass) collected during dry and wet seasons and three concentrate feed samples (rice bran, copra meal and tofu waste) were dried and ground. The feed sample (200 g) was transferred into incubation syringe which was then added with incubation medium (mixture of rumen fluid and buffer solution). The rumen fluid was collected from 2 Timor deer using a trokar technique. Incubation was run for 72 h, and gas production was read at 2, 4, 6, 12, 24, 48, and 72 h of incubation. Data were fitted to an exponential equation generally used in similar in vitro gas production studies. Results of the study indicated that there was an effect of season on fermentation parameters (values of a, b or c) for the same feed, but this effect was not consistent from one feed to another. From data of total and cummulative gas productions, it was indicated that Zea mays in either dry or wet season showed the highest, while Leucaena leucocephala exhibited the lowest gas production compared to other feeds tested