Custos de transação e comportamento da base para o preço do milho em Rio Verde, GO.

O objetivo deste trabalho foi analisar o comportamento da base, que é a diferença entre o preço do milho de Rio Verde, GO, e o preço futuro do milho na BM&FBovespa de 3/1/2005 até 15/3/2011. Por conseguinte, a hipótese do estudo é que os custos de transação e as características regionais da comercialização do milho fazem que ocorra elevada divergência de preços entre os mercados. O modelo autorregressivo com threshold (TAR) foi usado para captar as importantes dimensões dos custos de transação. Os resultados estimados para o parâmetro TAR de 7,78% mostram uma fraca convergência entre os preços dos mercados e, por consequência, o enfraquecimento da base na região. Isso evidencia que os produtores minimizam custos de transação regionais e, por isso, estão mais preocupados com as transações de hedging privado no mercado físico, não recorrendo à bolsa de valores para proteção contra oscilação de preços

Rhabdomyolysis: a genetic perspective

Rhabdomyolysis (RM) is a clinical emergency characterized by fulminant skeletal muscle damage and release of intracellular muscle components into the blood stream leading to myoglobinuria and, in severe cases, acute renal failure. Apart from trauma, a wide range of causes have been reported including drug abuse and infections. Underlying genetic disorders are also a cause of RM and can often pose a diagnostic challenge, considering their marked heterogeneity and comparative rarity.In this paper we review the range of rare genetic defects known to be associated with RM. Each gene has been reviewed for the following: clinical phenotype, typical triggers for RM and recommended diagnostic approach. The purpose of this review is to highlight the most important features associated with specific genetic defects in order to aid the diagnosis of patients presenting with hereditary causes of recurrent RM

Rhabdomyolysis: a genetic perspective

Rhabdomyolysis (RM) is a clinical emergency characterized by fulminant skeletal muscle damage and release of intracellular muscle components into the blood stream leading to myoglobinuria and, in severe cases, acute renal failure. Apart from trauma, a wide range of causes have been reported including drug abuse and infections. Underlying genetic disorders are also a cause of RM and can often pose a diagnostic challenge, considering their marked heterogeneity and comparative rarity. In this paper we review the range of rare genetic defects known to be associated with RM. Each gene has been reviewed for the following: clinical phenotype, typical triggers for RM and recommended diagnostic approach. The purpose of this review is to highlight the most important features associated with specific genetic defects in order to aid the diagnosis of patients presenting with hereditary causes of recurrent RM.</p

Manejo de irrigação para cafeeiros propagador por embriogênese somática

A irrigação do cafeeiro tem se tornado prática cada vez mais frequente e necessária, uma vez que a cafeicultura tem migrado para regiões antes consideradas não aptas ao cultivo do café. Mesmo em regiões consideradas aptas quanto a deficiência hídrica como a região do sul de Minas, o uso da irrigação vem se tornando prática crescente. Porém, ainda são escassos os estudos sobre a adaptabilidade de cafeeiros provenientes de embriogênese somática a irrigação em condições de campo. Dessa maneira o objetivo desse trabalho foi determinar os níveis adequados de reposição de água de irrigação para cafeeiros oriundos de mudas propagadas por embriogênese somática. O experimento foi instalado no setor de cafeicultura da Universidade Federal de Lavras, onde foram plantadas mudas de Siriema, clone 03 resistente a ferrugem e ao bicho mineiro. O experimento foi instalado em blocos casualizados, com quatro repetições e seis tratamentos. Os tratamentos foram compostos de seis lâminas de irrigação baseadas em frações do Kc, constituídas de 0,4 (T2); 0,7 (T3); 1,0 (T4); 1,3 (T5); 1,6 (T6) e não irrigado (T1). Sendo aplicadas 75,22; 131,63; 188,05; 244,46 e 300,88 mm respectivamente aos tratamentos T2, T3, T4, T5 e T6. Foram avaliados durante o período de um ano após a implantação da lavoura a altura e o diâmetro de copa dos cafeeiros, sendo a parcela constituída por oito plantas e avaliada as seis plantas centrais. Os resultados mostraram que as parcelas irrigadas apresentaram aumento do Índice de área foliar (IAF) até uma lâmina máxima de 225,25 mm, correspondente a fração de 1,2 do Kc. Este crescimento correspondeu a 1,46 m².m-2 do IAF, cerca de 43,13% a mais que as parcelas não irrigadas

From exercise intolerance to functional improvement: The second wind phenomenon in the identification of McArdle disease

McArdle disease is the most common of the glycogen storage diseases. Onset of symptoms is usually in childhood with muscle pain and restricted exercise capacity. Signs and symptoms are often ignored in children or put down to 'growing pains' and thus diagnosis is often delayed. Misdiagnosis is not uncommon because several other conditions such as muscular dystrophy and muscle channelopathies can manifest with similar symptoms. A simple exercise test performed in the clinic can however help to identify patients by revealing the second wind phenomenon which is pathognomonic of the condition. Here a patient is reported illustrating the value of using a simple 12 minute walk test.RSS is funded by Ciências sem Fronteiras/CAPES Foundation. The authors would like to thank the Association for Glycogen Storage Disease (UK), the EUROMAC Registry funded by the European Union, the Muscular Dystrophy Campaign, the NHS National Specialist Commissioning Group and the Myositis Support Group for funding

CAV3 mutations causing exercise intolerance, myalgia and rhabdomyolysis: expanding the phenotypic spectrum of caveolinopathies

Rhabdomyolysis is often due to a combination of environmental trigger(s) and genetic predisposition; however, the underlying genetic cause remains elusive in many cases. Mutations in CAV3 lead to various neuromuscular phenotypes with partial overlap, including limb girdle muscular dystrophy type 1C (LGMD1C), rippling muscle disease, distal myopathy and isolated hyperCKemia. Here we present a series of eight patients from seven families presenting with exercise intolerance and rhabdomyolysis caused by mutations in CAV3 diagnosed by next generation sequencing (NGS) (n=6). Symptoms included myalgia (n=7), exercise intolerance (n=6) and episodes of rhabdomyolysis (n=2). Percussion-induced rapid muscle contractions (PIRCs) were seen in five out of six patients examined. A previously reported heterozygous mutation in CAV3 (p.T78M) and three novel variants (p.V14I, p.F41S, p.F54V) were identified. Caveolin-3 immunolabeling in muscle was normal in 3/4 patients however, immunoblotting showed more than 50% reduction of caveolin-3 in five patients compared with controls. This case series demonstrates that exercise intolerance, myalgia and rhabdomyolysis may be caused by CAV3 mutations and broadens the phenotypic spectrum of caveolinopathies. In our series immunoblotting was a more sensitive method to detect reduced caveolin-3 levels than immunohistochemistry in skeletal muscle. Patients presenting with muscle pain, exercise intolerance and rhabdomyolysis should be routinely tested for PIRCs as this may be an important clinical clue for caveolinopathies, even in the absence of other “typical” features. The use of NGS may expand current knowledge concerning inherited diseases, and unexpected/atypical phenotypes may be attributed to well-known human disease genes

Resistance Exercise Training in McArdle Disease: Myth or Reality?

McArdle disease is a metabolic myopathy mainly characterised by symptom onset during physical activities or isometric muscle contraction. Resistance (also termed strength) training is a type of physical exercise focusing on the use of resistance (e.g., lifing weights) to induce muscular contraction, which builds muscle mass and strength. Historically people with McArdle disease were advised to avoid resistance exercises and any other form of physical activity involving high mechanical loads such as prolonged isometric contraction. Paradoxically, a clinical trial exploring the benefts of strength training in this patient population was published. Te theory supporting strength training relied on the use of the ATP molecule and the creatine phosphate (ATPphosphocreatine system) as energy sources for skeletal muscles. Here, we report two patients with McArdle disease who performed weight training at local gyms. A single set of repetitions lasted for maximum 10 seconds with minimum of 30 seconds of rest period in between sets of exercises. Benefts of this type of training included improvement in quality of life and amelioration of McArdle disease symptoms. We provide further safety evidence of this type of exercise in people with McArdle disease. We emphasise the importance of using a specifc protocol developed for people afected by this condition

First observational evidence of a relation between globular clusters' internal rotation and stellar masses

Several observational studies have shown that many Galactic globular clusters (GCs) are characterised by internal rotation. Theoretical studies of the dynamical evolution of rotating clusters have predicted that, during their long-term evolution, these stellar systems should develop a dependence of the rotational velocity around the cluster's centre on the mass of stars, with the internal rotation increasing for more massive stars. In this paper we present the first observational evidence of the predicted rotation-mass trend. In our investigation, we exploited the $\mathit{Gaia}$ Data Release 3 catalogue of three GCs: NGC 104 (47 Tuc), NGC 5139 ($\omega$ Cen) and NGC 5904 (M 5). We found clear evidence of a cluster rotation-mass relation in 47 Tuc and M 5, while in $\omega$ Cen, the dynamically youngest system among the three clusters studied here, no such trend was detected.Comment: 6 pages, 4 figures, 1 table. Accepted for publication in MNRAS Letter