Retrospective study on the incidence of envenomation and accessibility to antivenom in Burkina Faso

Background: Snakebite is a common neglected public health issue, especially in poor rural areas of sub-Saharan Africa, Asia and Latin America. Passive immunotherapy with safe and effective antivenom is the only approved treatment for it. This study aimed to determine the incidence of snakebites, and to assess the availability and accessibility of antivenoms, from 2010 to 2014, in Burkina Faso. Methods: The assessment of snakebite cases managed in all health facilities from 2010 to 2014 was performed from the Statistical Yearbook of the Ministry of Health. Antivenom consumption data were collected from the drug wholesalers established in Burkina Faso. Results: Snakebites are among the five leading causes of consultations in health districts. From 2010 to 2014, 114,126 envenomation cases occurred in Burkina Faso, out of which 62,293 (54.6 %) victims have been hospitalized resulting in 1,362 (2 %) deaths. The annual incidence and mortality were respectively 130 bites and 1.75 deaths per 100,000 inhabitants. The amount of antivenom sold by wholesalers were 5,738 vials with a total cost of US$539,055 (annual average = US$ 107,811). The high cost of these antivenoms (between US$42 and 170 per dose according to brand) limited their use by rural people, the main victims of snakebites, whose income is insufficient. Thus, only 4$ 3.4 by a public drug wholesaler. Conclusion: The study confirmed the high burden of snakebites in Burkina Faso. To better manage envenomation, Burkina Faso implemented a strategy consisting in seeking affordable sources of antivenom supply of good quality and innovative mechanisms of subsidy

« Définition consensuelle du faux médicament : une étape ultime pour une harmonisation internationale des législations réprimant le trafic de faux médicaments »

International audienc

Progress in developing amphiphilic cyclodextrin-based nanodevices for drug delivery

International audienc

Self-assembled biotransesterified cyclodextrins as Artemisinin nanocarriers - I: Formulation, lyoavailability and <i>in vitro</i> antimalarial activity assessment

International audienc

Mise en gélules d’une poudre d'écorces de racine de Cassia sieberiana DC, Caesalpiniaceae, plante utilisée par les tradipraticiens de Ouagadougou pour le traitement de l’infection à VIH

Français Au cours de cette étude, nous avons mis au point des formulations de gélules contenant de la poudre d'écorcede racine de Cassia sieberiana DC, Caesalpiniaceae, une plante utilisée par les tradipraticiens de la ville deOuagadougou pour la prise en charge des personnes vivant avec le VIH. Pour ce faire, la granulométrie et ladensité apparente de la poudre obtenue directement du tradipraticien ont été analysées. Ensuite, des gélulescontenant la drogue, en présence ou non d’AérosilÒ 200 (agent de glissement) ont été préparées et soumisesaux tests d’uniformité de masse et de désagrégation. Les résultats obtenus ont montré une très large distributiongranulométrique de la poudre et une variation inter-individu importante de la posologie proposée par letradipraticien. Egalement, la présence de l’AérosilÒ 200 améliore la densité apparente de la poudre après tassementet l'uniformité du remplissage. Finalement, les différentes formulations sont conformes aux spécificationsde la pharmacopée européenne, en ce qui concerne l'uniformité de masse et le temps de délitage. &nbsp; Anglais Hard capsule formulations, containing root bark powder of Cassia sieberiana DC, Caesalpiniaceae, traditionallyused by traditional healers of Ouagadougou (Burkina Faso) for HIV/AIDS management, have been performedand evaluated. For these purposes, the distribution of particle sizes and the tape density of the powderhave been examined. Then, capsules containing powder, formulated with or without AerosilÒ 200, a glidingagent, were prepared and undergone tests of content uniformity and desegregation. The results showed a highlarge distribution of the powder particle sizes and an important variation inter-subject of the posology proposedby the traditional prescription. Moreover, the presence of AerosilÒ 200 improved the tape density of powderand the uniformity of the capsule filling. Finally, the different formulations met the requirements of theEuropean pharmacopoeia, concerning the content uniformity and the desegregation time

Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization

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