Systemic Therapy in Endometrial Cancer: Recent Advances.

Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well. As more molecular pathways are being elucidated there is increasing role for targeted agents and future looks quite promising. We did an extensive search both online and offline for all the relevant articles including chemotherapy and targeted therapy for endometrial cancer

IMF isotopic properties in semi-peripheral collisions at Fermi energies

We study the neutron and proton dynamical behavior along the fragmentation path in semi-peripheral collisions: 58Fe+58Fe (charge asymmetric, N/Z = 1.23) and 58Ni+58Ni (charge symmetric, N/Z = 1.07), at 47 AMeV. We observe that isospin dynamics processes take place also in the charge-symmetric system 58Ni+58Ni, that may produce more asymmetric fragments. A neutron enrichment of the neck fragments is observed, resulting from the interplay between pre-equilibrium emission and the phenomenon of "isospin-migration". Both effects depend on the EoS (Equation of State) symmetry term. This point is illustrated by comparing the results obtained with two different choices of the symmetry energy density dependence. New correlation observables are suggested, to study the reaction mechanism and the isospin dynamics.Comment: 5 pages, 8 figures, Revtex4 Latex Styl

Timescale for equilibration of N/Z gradients in dinuclear systems

Equilibration of N/Z in binary breakup of an excited and transiently deformed projectile-like fragment (PLF*), produced in peripheral collisions of 64Zn + 27Al, 64Zn, 209Bi at E/A = 45 MeV, is examined. The composition of emitted light fragments (3<=Z<=6) changes with the decay angle of the PLF*. The most neutron-rich fragments observed are associated with a small rotation angle. A clear target dependence is observed with the largest initial N/Z correlated with the heavy, neutron-rich target. Using the rotation angle as a clock, we deduce that N/Z equilibration persists for times as long as 3-4 zs (1zs = 1 x 10^-21 s = 300 fm/c). The rate of N/Z equilibration is found to depend on the initial neutron gradient within the PLF*.Comment: 6 pages, 4 figure

The Mass-Size Relation from Clouds to Cores. I. A new Probe of Structure in Molecular Clouds

We use a new contour-based map analysis technique to measure the mass and size of molecular cloud fragments continuously over a wide range of spatial scales (0.05 < r / pc < 10), i.e., from the scale of dense cores to those of entire clouds. The present paper presents the method via a detailed exploration of the Perseus Molecular Cloud. Dust extinction and emission data are combined to yield reliable scale-dependent measurements of mass. This scale-independent analysis approach is useful for several reasons. First, it provides a more comprehensive characterization of a map (i.e., not biased towards a particular spatial scale). Such a lack of bias is extremely useful for the joint analysis of many data sets taken with different spatial resolution. This includes comparisons between different cloud complexes. Second, the multi-scale mass-size data constitutes a unique resource to derive slopes of mass-size laws (via power-law fits). Such slopes provide singular constraints on large-scale density gradients in clouds.Comment: accepted to ApJ; references updated in new versio

Distribution and mass of diffuse and dense CO gas in the Milky Way

This is the final version of the article. Available from American Astronomical Society and IOP Publishing via the DOI in this record.Emission from carbon monoxide (CO) is ubiquitously used as a tracer of dense star-forming molecular clouds. There is, however, growing evidence that a significant fraction of CO emission originates from diffuse molecular gas. Quantifying the contribution of diffuse CO-emitting gas is vital for understanding the relation between molecular gas and star formation. We examine the Galactic distribution of two CO-emitting gas components, a high column density component detected in 13CO and 12CO, and a low column density component detected in 12CO, but not in 13CO. The “diffuse” and “dense” components are identified using a combination of smoothing, masking, and erosion/dilation procedures, making use of three large-scale 12CO and 13CO surveys of the inner and outer Milky Way. The diffuse component, which globally represents 25% (1.5 × 108M⊙) of the total molecular gas mass (6.5 × {10}8 M⊙), is more extended perpendicular to the Galactic plane. The fraction of diffuse gas increases from ∼10%–20% at a galactocentric radius of 3–4 kpc to 50% at 15 kpc, and increases with decreasing surface density. In the inner Galaxy, a yet denser component traced by CS emission represents 14% of the total molecular gas mass traced by 12CO emission. Only 14% of the molecular gas mass traced by 12CO emission is identified as part of molecular clouds in 13CO surveys by cloud identification algorithms. This study indicates that CO emission not only traces star-forming clouds, but also a significant diffuse molecular ISM component.R.S. and R.S.K. acknowledge support from the Deutsche Forschungsgemeinschaft (DFG) for funding through the SPP 1573 “The Physics of the Interstellar Medium” as well as via SFB 881 “The Milky Way System” (sub-projects B12, and B8). R.S.K. also receives funding from the European Research Council under the European Communitys Seventh Framework Program (FP7/2007-2013) via the ERC Advanced Grant “STARLIGHT” (project number 339177)

The Mass-Size Relation from Clouds to Cores. II. Solar Neighborhood Clouds

We measure the mass and size of cloud fragments in several molecular clouds continuously over a wide range of spatial scales (0.05 < r / pc < 3). Based on the recently developed "dendrogram-technique", this characterizes dense cores as well as the enveloping clouds. "Larson's 3rd Law" of constant column density, m(r) = C*r^2, is not well suited to describe the derived mass-size data. Solar neighborhood clouds not forming massive stars (< 10 M_sun; Pipe Nebula, Taurus, Perseus, and Ophiuchus) obey m(r) < 870 M_sun (r / pc)^1.33 . In contrast to this, clouds forming massive stars (Orion A, G10.15$-$0.34, G11.11$-$0.12) do exceed the aforementioned relation. Thus, this limiting mass-size relation may approximate a threshold for the formation of massive stars. Across all clouds, cluster-forming cloud fragments are found to be---at given radius---more massive than fragments devoid of clusters. The cluster-bearing fragments are found to roughly obey a mass-size law m = C*r^1.27 (where the exponent is highly uncertain in any given cloud, but is certainly smaller than 1.5).Comment: accepted to the Astrophysical Journa

Phase diagram of neutron-rich nuclear matter and its impact on astrophysics

Dense matter as it can be found in core-collapse supernovae and neutron stars is expected to exhibit different phase transitions which impact the matter composition and equation of state, with important consequences on the dynamics of core-collapse supernova explosion and on the structure of neutron stars. In this paper we will address the specific phenomenology of two of such transitions, namely the crust-core solid-liquid transition at sub-saturation density, and the possible strange transition at super-saturation density in the presence of hyperonic degrees of freedom. Concerning the neutron star crust-core phase transition at zero and finite temperature, it will be shown that, as a consequence of the presence of long-range Coulomb interactions, the equivalence of statistical ensembles is violated and a clusterized phase is expected which is not accessible in the grand-canonical ensemble. A specific quasi-particle model will be introduced to illustrate this anomalous thermodynamics and some quantitative results relevant for the supernova dynamics will be shown. The opening of hyperonic degrees of freedom at higher densities corresponding to the neutron stars core modifies the equation of state. The general characteristics and order of phase transitions in this regime will be analyzed in the framework of a self-consistent mean-field approach.Comment: Invited Talk given at the 11th International Conference on Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1, 2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference Series (JPCS

Enhanced Production of Neutron-Rich Rare Isotopes in Peripheral Collisions at Fermi Energies

A large enhancement in the production of neutron-rich projectile residues is observed in the reactions of a 25 MeV/nucleon 86Kr beam with the neutron rich 124Sn and 64Ni targets relative to the predictions of the EPAX parametrization of high-energy fragmentation, as well as relative to the reaction with the less neutron-rich 112Sn target. The data demonstrate the significant effect of the target neutron-to-proton ratio (N/Z) in peripheral collisions at Fermi energies. A hybrid model based on a deep-inelastic transfer code (DIT) followed by a statistical de-excitation code appears to account for part of the observed large cross sections. The DIT simulation indicates that the production of the neutron-rich nuclides in these reactions is associated with peripheral nucleon exchange. In such peripheral encounters, the neutron skins of the neutron-rich 124Sn and 64Ni target nuclei may play an important role. From a practical viewpoint, such reactions between massive neutron-rich nuclei offer a novel and attractive synthetic avenue to access extremely neutron-rich rare isotopes towards the neutron-drip line.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let