Effective Bug Assortment Using Data Reduction Techniques

Software companies spend over 48% of their total cost to fix the bugs. An effective way to automatically fix the bugs to the correct developer is called Bug Triage or Bug Assortment. Data sets containing the bug reports are collected from two large open source projects like Mozilla and Firefox. These projects consist of open source bug repositories. Bug repositories are large repositories which stores all the details of bugs. The details are stored in the form of a bug report. These bug report are saved as a document and a related developer is mapped to the label of the document. Software companies spend most of their total cost in fixing these bugs. In bug repositories the two main challenges faced is the large quantity of the data set and the low quality. Noise and redundancy are the main cause for the low quality of the data set. However, irrespective of all these difficulties assigning a proper developer to fix the bug is not an easy task without knowing the actual class of the bug. In this paper we propose data reduction technique which reduces the high scale of the data but it retains the quality of the data set. We also propose domain wise bug solution

Changes in biological productivity associated with Ningaloo Niño / Niña events in the southern subtropical Indian Ocean in recent decades

Using observations and long term simulations of an ocean-biogeochemical coupled model, we investigate the biological response in the southern subtropical Indian Ocean (SIO) associated with Ningaloo Niño and Niña events. Ningaloo events have large impact on sea surface temperature (SST) with positive SST anomalies (SSTA) seen off the west coast of Australia in southern SIO during Ningaloo Niño and negative anomalies during Niña events. Our results indicate that during the developing period of Ningaloo Niño, low chlorophyll anomaly appears near the southwest Australian coast concurrently with high SSTA and vice-versa during Niña, which alter the seasonal cycle of biological productivity. The difference in the spatiotemporal response of chlorophyll is due to the southward advection of Leeuwin current during these events. Increased frequency of Ningaloo Niño events associated with cold phase of Pacific Decadal Oscillation (PDO) resulted in anomalous decrease in productivity during Austral summer in the SIO in the recent decades

Isosorbide dinitrate, with or without hydralazine, does not reduce wave reflections, left ventricular hypertrophy, or myocardial fibrosis in patients with heart failure with preserved ejection fraction

Background-Wave reflections, which are increased in patients with heart failure with preserved ejection fraction, impair diastolic function and promote pathologic myocardial remodeling. Organic nitrates reduce wave reflections acutely, but whether this is sustained chronically or affected by hydralazine coadministration is unknown. Methods and Results-We randomized 44 patients with heart failure with preserved ejection fraction in a double-blinded fashion to isosorbide dinitrate (ISDN; n=13), ISDN+hydralazine (ISDN+hydral; n=15), or placebo (n=16) for 6months. The primary end point was the change in reflection magnitude (RM; assessed with arterial tonometry and Doppler echocardiography). Secondary end points included change in left ventricular mass and fibrosis, measured with cardiac magnetic resonance imaging, and the 6-minute walk distance. ISDN reduced aortic characteristic impedance (mean baseline=0.15 [95% CI, 0.14-0.17], 3 months=0.11 [95% CI, 0.10-0.13], 6 months=0.10 [95% CI, 0.08-0.12] mmHg/mL per second; P=0.003) and forward wave amplitude (P-f, mean baseline=54.8 [95% CI, 47.6-62.0], 3 months=42.2 [95% CI, 33.2-51.3]; 6 months=37.0 [95% CI, 27.2-46.8] mmHg, P=0.04), but had no effect on RM (P=0.64), left ventricular mass (P=0.33), or fibrosis (P=0.63). ISDN+hydral increased RM (mean baseline=0.39 [95% CI, 0.35-0.43]; 3 months=0.31 [95% CI, 0.25-0.36]; 6 months=0.44 [95% CI, 0.37-0.51], P=0.03), reduced 6-minute walk distance (mean baseline=343.3 [95% CI, 319.2-367.4]; 6 months=277.0 [95% CI, 242.7-311.4] meters, P=0.022), and increased native myocardial T1 (mean baseline=1016.2 [95% CI, 1002.7-1029.7]; 6 months=1054.5 [95% CI, 1036.5-1072.3], P=0.021). A high proportion of patients experienced adverse events with active therapy (ISDN=61.5%, ISDN+hydral=60.0%; placebo=12.5%; P=0.007). Conclusions-ISDN, with or without hydralazine, does not exert beneficial effects on RM, left ventricular remodeling, or submaximal exercise and is poorly tolerated. ISDN+hydral appears to have deleterious effects on RM, myocardial remodeling, and submaximal exercise. Our findings do not support the routine use of these vasodilators in patients with heart failure with preserved ejection fraction

van der Woude syndrome- a syndromic form of orofacial clefting

van der Woude Syndrome is the most common form of syndromic orofacial clefting, accounting for 2% of all cases, and has the phenotype that most closely resembles the more common non-syndromic forms. The syndrome has an autosomal dominant hereditary pattern with variable expressivity and a high degree of penetrance with cardinal clinical features of lip pits with a cleft lip, cleft palate, or both. This case report describes van der Woude syndrome in a 19 year old male patient with a specifi c reference to the various aspects of this condition, as clinical appearance, etiological factors (genetic aspects), differential diagnosis, investigative procedures and management

The microbiological profile of lacrimal abscess: two decades of experience from a tertiary eye care center

BACKGROUND: The aim of this study is to exclusively report the microbiological spectrum of lacrimal abscess and the antibiotic sensitivity patterns of the organisms. Retrospective interventional study on 112 eyes of 112 patients who presented to the ophthalmic plastic clinic of a tertiary eye care center over a period of 23 years from January 1990 to February 2013 with lacrimal abscess were reviewed for demographic and microbiological profile. The culture results, organisms isolated, and their antibiotic sensitivity were studied. RESULTS: The mean age at presentation was 37 years. The female to male ratio was 2:1. There was no significant difference in the laterality between the right and left eyes. Gram-positive organisms were the most commonly isolated accounting for 56.3% (63/112), and the commonest species isolated was Staphylococcus aureus in 25% (28/112) of the patients. Hemophilus influenzae was the commonest gram-negative isolate accounting for 30.2% of all the gram-negative isolates. Of the patients, 10.7% (12/112) showed no organisms on smear as well as sterile cultures. Gram-positive organisms were commonly sensitive to penicillins and vancomycin whereas gram-negative organisms were sensitive to quinolones and aminoglycosides. CONCLUSIONS: Gram-positive organisms are quite common as compared to gram-negative ones in cases of lacrimal abscess. The results of this study have significant bearing on the treatment of patients with lacrimal abscess

Intersecting 6-branes from new 7-manifolds with G_2 holonomy

We discuss a new family of metrics of 7-manifolds with G_2 holonomy, which are R^3 bundles over a quaternionic space. The metrics depend on five parameters and have two Abelian isometries. Certain singularities of the G_2 manifolds are related to fixed points of these isometries; there are two combinations of Killing vectors that possess co-dimension four fixed points which yield upon compactification only intersecting D6-branes if one also identifies two parameters. Two of the remaining parameters are quantized and we argue that they are related to the number of D6-branes, which appear in three stacks. We perform explicitly the reduction to the type IIA model.Comment: 25 pages, 1 figure, Latex, small changes and add refs, version appeared in JHE

Black hole entropy functions and attractor equations

The entropy and the attractor equations for static extremal black hole solutions follow from a variational principle based on an entropy function. In the general case such an entropy function can be derived from the reduced action evaluated in a near-horizon geometry. BPS black holes constitute special solutions of this variational principle, but they can also be derived directly from a different entropy function based on supersymmetry enhancement at the horizon. Both functions are consistent with electric/magnetic duality and for BPS black holes their corresponding OSV-type integrals give identical results at the semi-classical level. We clarify the relation between the two entropy functions and the corresponding attractor equations for N=2 supergravity theories with higher-derivative couplings in four space-time dimensions. We discuss how non-holomorphic corrections will modify these entropy functions.Comment: 21 pages,LaTeX,minor change

A tachyonic extension of the stringy no-go theorem

We investigate the tachyon-dilaton-metric system to study the "graceful exit" problem in string theoretic inflation, where tachyon plays the role of the scalar field. From the phase space analysis, we find that the inflationary phase does not smoothly connect to a Friedmann-Robertson-Walker (FRW) expanding universe, thereby providing a simple tachyonic extension of the recently proved stringy no-go theorem.Comment: TeX file (PHYZZX), 10 pages, change in the title, many changes in the text (the version to appear in Phys. Rev. D

A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation

High-throughput technologies revealed new categories of genes, including the long noncoding RNAs (lncRNAs), involved in the pathogenesis of human disease; however, the role of lncRNAs in the ulcerative colitis (UC) has not been evaluated. Gene expression profiling was used to develop lncRNA signatures in UC samples. Jurkat T cells were activated by PMA/ionomycin subsequently interferon- (IFNG) and tumor necrosis factor (TNF)- protein levels were assessed by ELISA. Anti-sense molecules were designed to block IFNG-AS1 expression. A unique set of lncRNAs was differentially expressed between UC and control samples. Of these, IFNG-AS1 was among the highest statistically significant lncRNAs (fold change: 5.27, P value: 7.07E-06). Bioinformatic analysis showed that IFNG-AS1 was associated with the IBD susceptibility loci SNP rs7134599 and its genomic location is adjacent to the inflammatory cytokine IFNG. In mouse models of colitis, active colitis samples had increased colonic expression of this lncRNA. Utilizing the Jurkat T cell model, we found IFNG-AS1 to positively regulate IFNG expression. Novel lncRNA signatures differentiate UC patients with active disease, patients in remission, and control subjects. A subset of these lncRNAs was found to be associated with the clinically validated IBD susceptibility loci. IFNG-AS1 was one of these differentially expressed lncRNAs in UC patients and found to regulate the key inflammatory cytokine, IFNG, in CD4 T cells. Taking these findings together, our study revealed novel lncRNA signatures deregulated in UC and identified IFNG-AS1 as a novel regulator of IFNG inflammatory responses, suggesting the potential importance of noncoding RNA mechanisms on regulation of inflammatory bowel disease-related inflammatory responses