A study of the effect of space radiation on silicon integrated circuits, phase 3, volume 2 Final report, 10 Apr. 1967 - 9 Apr. 1968

Characterization plans for studying effect of space radiation on silicon integrated microcircuit

Stability of string defects in models of non-Abelian symmetry breaking

In this paper we describe a new type of topological defect, called a homilia string, which is stabilized via interactions with the string network. Using analytical and numerical techniques, we investigate the stability and dynamics of homilia strings, and show that they can form stable electroweak strings. In SU(2)xU(1) models of symmetry breaking the intersection of two homilia strings is identified with a sphaleron. Due to repulsive forces, the homilia strings seperate, resulting in sphaleron annihilation. It is shown that electroweak homilia string loops cannot stabilize as vortons, which circumvents the adverse cosmological problems associated with stable loops. The consequences for GUT scale homilia strings are also discussed.Comment: 15 pages, revtex, with 8 figures. Submitted to PR

A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties

INTRODUCTION: Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis. Thus, anti-inflammatory drugs have been widely explored as chemopreventive and antineoplastic agents. Aspirin (ASA), in particular, is associated with reduced breast cancer incidence but gastrointestinal toxicity has limited its usefulness. To improve potency and minimize toxicity, ASA ester prodrugs have been developed, in which the carboxylic acid of ASA is masked and ancillary pharmacophores can be incorporated. To date, the effects of ASA and ASA prodrugs have been largely attributed to COX inhibition and reduced prostaglandin production. However, ASA has also been reported to inhibit the NFκB pathway at very high doses. Whether ASA prodrugs can inhibit NFκB signaling remains relatively unexplored. METHODS: A library of ASA prodrugs was synthesized and screened for inhibition of NFκB activity and cancer stem-like cell (CSC) properties, an important PGE2-and NFκB-dependent phenotype of aggressive breast cancers. Inhibition of NFκB activity was determined by dual luciferase assay, RT-QPCR, p65 DNA binding activity and Western blots. Inhibition of CSC properties was determined by mammosphere growth, CD44(+)CD24(−)immunophenotype and tumorigenicity at limiting dilution. RESULTS: While we identified multiple ASA prodrugs that are capable of inhibiting the NFκB pathway, several were associated with cytotoxicity. Of particular interest was GTCpFE, an ASA prodrug with fumarate as the ancillary pharmacophore. This prodrug potently inhibits NFκB activity without innate cytotoxicity. In addition, GTCpFE exhibited selective anti-CSC activity by reducing mammosphere growth and the CD44(+)CD24(−)immunophenotype. Moreover, GTCpFE pre-treated cells were less tumorigenic and, when tumors did form, latency was increased and growth rate was reduced. Structure-activity relationships for GTCpFE indicate that fumarate, within the context of an ASA prodrug, is essential for anti-NFκB activity, whereas both the ASA and fumarate moieties contributed to attenuated mammosphere growth. CONCLUSIONS: These results establish GTCpFE as a prototype for novel ASA-and fumarate-based anti-inflammatory drugs that: (i) are capable of targeting CSCs, and (ii) may be developed as chemopreventive or therapeutic agents in breast cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-1868-7) contains supplementary material, which is available to authorized users

Thirty Years and Counting: Do We Still Need the ICIS Women’s Breakfast?

This article discusses an important panel held at ICIS 2011 in Shanghai to mark over thirty years of an ICIS institution, the ICIS Women’s Breakfast. The panel addressed the controversial question—is there still a need for the ICIS Women’s Breakfast? Panelists were asked if the ICIS Women’s Breakfast could be seen as divisive, and if, women’s issues are different from issues of diversity such as race or sexual  orientation. They were also asked why they thought women were still  underrepresented in our academic community, and if the lack of women at senior levels was a concern for the community. Finally, the panelists were asked what practices the community would need to adopt to combat what could be seen as structural discrimination in our community, which we believe reflects the wider world we live in. We frame the debate and the ensuing discussion in the literature about women in academia, and conclude with some practical and constructive  recommendations for the community as a whole

Seismicity and Tectonics of the Northern Gulf of California Region, Mexico. Preliminary Results

Three new seismographic statioms have been established· in the northern Gulf of California region; Mexico. Seismicity ,during a representative period in April and May of 1969 was concentrated on the Imperial, San Jacinto, Sierra Juarez, .and San Miguel faults, and the spread of epicentral locations was m\!Ch less than had previously been indicated. An intense earthquake swarm in March of· 1969 occurred near Consag Rock in the northern Gulf, and its study contributes to our understanding of the regional tectonics. In the northern Gulf of California and adjacent Salton trough, the tectonic framework may be. approximated by a series of six transform faults connected by five spreading centers (ridge, segments) evidenced by geothermal areas, recent .. volcanic activity, earthquake swarms, and submarine topographic depressions. Complexities in the fault pattern may be related to a northward decrease in spreading rates along the ridge segment,s. Five new high; quality seismographic stations around the •Gulf of California are now under construction in order to understand in more detail the pattern of sea-floor spreading in this unique, and important region

1st ESMO Consensus Conference in lung cancer; Lugano 2010: Small-cell lung cancer

The 1st ESMO Consensus Conference on lung cancer was held in Lugano, Switzerland on 21st and 22nd May 2010 with the participation of a multidisciplinary panel of leading professionals in pathology and molecular diagnostics and medical, surgical and radiation oncology. Before the conference, the expert panel prepared clinically relevant questions concerning five areas as follows: early and locally advanced non-small-cell lung cancer (NSCLC), first-line metastatic NSCLC, second-/third-line NSCLC, NSCLC pathology and molecular testing, and small-cell lung cancer (SCLC) to be addressed through discussion at the Consensus Conference. All relevant scientific literature for each question was reviewed in advance. During the Consensus Conference, the panel developed recommendations for each specific question. The consensus agreement in SCLC is reported in this article. The recommendations detailed here are based on an expert consensus after careful review of published data. All participants have approved this final updat