Embryo Form Project: An original technique for the three-dimensional reconstruction of human embryo morphology

International audienceOur current knowledge on the developmental stages of human embryogenesis has derived from limited numbers of classical studies. Computer technology now permits accurate 3D reconstruction of embryo morphology from serial histological sections. We present a successful technique that uses either fresh or preserved serial histological sections to generate highly detailed 3D image reconstructions of very small human embryos. We present the data we obtained from the reconstruction in virtual space of previously sectioned 15 and 22.5mm embryos. Their morphologies were studied using a DICOM viewer which permitted the analysis of any specific structure in any required orientation. To our knowledge, this is the first time human embryos have been reconstructed in this way. We believe that this reconstruction technique could improve our knowledge on embryo morphogenesis, especially if coupled to the study of genes involved in embryonic development. It may also prove to be a useful pedagogical tool

Endovascular treatment of ruptured intracranial aneurysms: Indications, techniques and results

AbstractRupture of an intracranial aneurysm is a diagnostic and therapeutic emergency. Occlusion of the aneurysm with coils is the first line treatment and should be performed promptly to avoid any further rupture, which carries a poor prognosis. Most aneurysms are accessible to this type of treatment. The risks of coiling, which are mostly thromboembolic and less commonly hemorrhagic due to peroperative rupture, are low. The use of stents or a flow diverter requires dual anti-aggregation which increases their risks so that their use are restricted to specific situations such as dissecting aneurysms. Endovascular treatment is effective in the long and short term prevention of recurrent hemorrhage provided that patients are followed up by imaging, which allows possible early recanalization to be detected early and treated if necessary