Cladribine tablets in relapsing-remitting multiple sclerosis preferentially target B-cells.

Recent studies demonstrate the efficacy of B cell-targeting therapies in managing multiple sclerosis (MS) activity, emphasizing the critical role of B cells in MS pathogenesis. CladB study aimed to quantify the temporal changes in peripheral immune cells and their activity over 96 weeks of Cladribine tablets (CladT) treatment in relapsing-remitting MS (RRMS). Ten participants (3 males, 7 females) had blood samples collected at multiple intervals (Day 0, 1, 5, then weekly for 8 weeks, biweekly for up to 24 weeks, and monthly for up to 96 weeks) for immune cell analysis, compared to a historical alemtuzumab-treated cohort. Paired cerebrospinal fluid (CSF) was also taken for various analyses, alongside clinical and brain imaging assessments. CladT depleted memory B cells, while alemtuzumab rapidly depleted T and B cells. The кFLC index decreased from 164.5 ± 227.1 to 71.3 ± 84.7 at 48 weeks (p = 0.002) and to 64.4 ± 67.3 at 96 weeks (p = 0.01). The IgG index dropped from 1.1 ± 0.5 at baseline to 0.8 ± 0.4 at 48 weeks (p = 0.014) and to 0.8 ± 0.3 at 96 weeks (p = 0.02). CSF CXCL-13 decreased from 88.6 ± 68.4 pg/mL to 39.4 ± 35.2 pg/mL at 48 weeks (p = 0.037) and 19.1 ± 11.7 pg/mL at 96 weeks (p = 0.027). CSF NfL levels were reduced at 48 weeks (p = 0.01). CladT primarily depletes memory B cells and antibody-secreting cell precursors in RRMS, leading to sustained effects on intrathecal antibody production and total IgG, and a reduction in CSF CXCL-13

Healthcare practitioners and robotic-assisted rehabilitation: understanding needs and barriers

Backgrounds: In recent years, numerous robotic devices, together with allied technologies, have been developed to support rehabilitation, both in research settings and industry. Although robotic-assisted rehabilitation and related technologies hold significant promise for supporting healthcare practitioners and enhancing patient care, their use in clinical practice remains limited. One of the motivations could be that final users’ needs have not been given due consideration so far. As a matter of fact, understanding user needs and perceptions is crucial for designing these technological devices and for creating new organizational models within hospitals aiming to establish and maintain robotics-assisted rehabilitation gyms. Methods: We developed and distributed an online survey to the Italian community of healthcare practitioners working in rehabilitation, to depict the current landscape of robotic-assisted rehabilitation and to understand their opinions and demands across various domains and diseases. The questionnaire is divided into two main parts. The first section pertains to the respondents' demographics and professional experience. The second part includes questions about eight different categories of rehabilitative devices. For each category, practitioners can indicate whether they use a device in their practice, their perceptions, and any perceived barriers. Additionally, they can fill out a System Usability Scale for a specific device in that category. Results: We collected answers from 423 Italian rehabilitation professionals, including various clinical roles, that revealed significant insights into the use of robotics in rehabilitation. Gender distribution shows a high prevalence of female professionals. 40% of respondents reported being unfamiliar with any robotics devices. Advanced treadmills are the most known and used robots. Generally, usage and experience with devices are associated with positive attitudes towards robotics-assisted rehabilitation. Lack of financial resources and scientific evidence, as well as lack of opportunities and training, are the most reported barriers. Conclusions: Despite a general positivity towards technology, there is a substantial lack of awareness about rehabilitation devices among professionals. The survey highlights the need for enhanced training and education on robotics in rehabilitation programs. Additionally, the limited focus on home rehabilitation is noted. The study emphasizes the importance of verifying both the effectiveness and economic sustainability of robotic devices in clinical practice

Mono-, bi-, and tri-metallic Ni-based catalysts for the catalytic hydrotreatment of pyrolysis liquids

Catalytic hydrotreatment is a promising technology to convert pyrolysis liquids into intermediates with improved properties. Here, we report a catalyst screening study on the catalytic hydrotreatment of pyrolysis liquids using bi- and tri-metallic nickel-based catalysts in a batch autoclave (initial hydrogen pressure of 140 bar, 350 A degrees C, 4 h). The catalysts are characterized by a high nickel metal loading (41 to 57 wt%), promoted by Cu, Pd, Mo, and/or combination thereof, in a SiO2, SiO2-ZrO2, or SiO2-Al2O3 matrix. The hydrotreatment results were compared with a benchmark Ru/C catalyst. The results revealed that the monometallic Ni catalyst is the least active and that particularly the use of Mo as the promoter is favored when considering activity and product properties. For Mo promotion, a product oil with improved properties viz. the highest H/C molar ratio and the lowest coking tendency was obtained. A drawback when using Mo as the promoter is the relatively high methane yield, which is close to that for Ru/C. H-1, C-13-NMR, heteronuclear single quantum coherence (HSQC), and two-dimensional gas chromatography (GC x GC) of the product oils reveal that representative component classes of the sugar fraction of pyrolysis liquids like carbonyl compounds (aldehydes and ketones and carbohydrates) are converted to a large extent. The pyrolytic lignin fraction is less reactive, though some degree of hydrocracking is observed

I maltrattamenti intrafamiliari ed extrafamiliari dell'anziano: come riconoscerli e prevenirli

Il fenomeno del maltrattamento sulla persona anziana con definizione, statistiche e caratteristiche. Il ruolo del medico legale nel riconoscimento dei segni di maltrattamento e nella prevenzione

PPM-based System for Guided Waves Communication Through Corrosion Resistant Multi-wire Cables

AbstractNovel wireless communication channels are a necessity in applications surrounded by harsh environments, for instance down-hole oil reservoirs. Traditional radio frequency (RF) communication schemes are not capable of transmitting signals through metal enclosures surrounded by corrosive gases and liquids. As an alternative to RF, a pulse position modulation (PPM) guided waves communication system has been developed and evaluated using a corrosion resistant 4H18 multi-wire cable, commonly used to descend electronic gauges in down-hole oil applications, as the communication medium. The system consists of a transmitter and a receiver that utilizes a PZT crystal, for electrical/mechanical coupling, attached to each extreme of the multi-wire cable. The modulator is based on a microcontroller, which transmits60kHz guided wave pulses, and the demodulator is based on a commercial digital signal processor (DSP) module that performs real time DSP algorithms. Experimental results are presented, which were obtained using a 1m corrosion resistant 4H18multi-wire cable, commonly used with downhole electronic gauges in the oil sector. Although there was significant dispersion and multiple mode excitations of the transmitted guided wave energy pulses, the results show that data rates on the order of 500 bits per second are readily available employing PPM and simple communications techniques

Guided wave sensor for simple digital communication through an oil industry multi-wire cable

This work presents the proprietary design and implementation of a lead zirconate titanate (PZT) sensor for simple digital transmission and reception of guided waves using a high-temperature and corrosion-resistant multiple-wire 1K22 MP-35N cable as a communication channel. These cables are commonly used in the hostile oil and gas borehole environments of the petroleum industry. The sensor design involves electrical/mechanical coupling, instrumentation and casing. The PZT guided wave transmitter instrumentation includes a microcontroller-based pulse position modulator, a signal booster, a PZT-5H crystal and a 9 V battery. The receiver sensor consists of a PZT-5H crystal, an amplifier and a real-time digital signal processing (RT DSP) and data acquisition module connected to a personal computer. Dispersion curves were obtained using Disperse software and a simplified model of the cable. Dynamic linear 3D finite element modelling of the sensor was performed to support the correct frequency selection. To evaluate the sensor design, the transmitter generated 60 kHz guided wave pulse position modulation (PPM) energy packages. Experimental tests were conducted in the laboratory using 1 m and 10 m cables. The results showed that, although there was significant dispersion and there were multiple mode excitations of the transmitted pulses, the system correctly identified 10-bit frames of guided wave PPM-encoded information.</jats:p