Preliminary catalog of pictures taken on the lunar surface during the Apollo 16 mission

A catalog of all pictures taken from the lunar module or the lunar surface during the Apollo 16 lunar stay is presented. The tabulations are arranged for the following specific uses: (1) given the number of a particular frame, find its location in the sequence of lunar surface activity, the station from which it was taken and the subject matter of the picture; (2) given a particular location or activity within the sequence of lunar surface activity, find the pictures taken at that time and their subject matter; and (3) given a sample number from the voice transcript listed, find the designation assigned to the same sample by the lunar receiving laboratory

Preliminary catalog of pictures taken on the lunar surface during the Apollo 15 mission

Catalog of all pictures taken from lunar module or lunar surface during Apollo 15 missio

GIVE: portable genome browsers for personal websites.

Growing popularity and diversity of genomic data demand portable and versatile genome browsers. Here, we present an open source programming library called GIVE that facilitates the creation of personalized genome browsers without requiring a system administrator. By inserting HTML tags, one can add to a personal webpage interactive visualization of multiple types of genomics data, including genome annotation, "linear" quantitative data, and genome interaction data. GIVE includes a graphical interface called HUG (HTML Universal Generator) that automatically generates HTML code for displaying user chosen data, which can be copy-pasted into user's personal website or saved and shared with collaborators. GIVE is available at: https://www.givengine.org/

Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals

Epithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic disease, but the basis for the altered epithelial phenotype is often uncertain. Here we show that long-term ciliated cell hyperplasia coincides with mucous (goblet) cell metaplasia after respiratory viral clearance in mouse airways. This chronic switch in epithelial behavior exhibits genetic susceptibility and depends on persistent activation of EGFR signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes transdifferentiation of ciliated to goblet cells. Thus, EGFR blockade (using an irreversible EGFR kinase inhibitor designated EKB-569) prevents virus-induced increases in ciliated and goblet cells whereas IL-13 blockade (using s-IL-13Rα2-Fc) exacerbates ciliated cell hyperplasia but still inhibits goblet cell metaplasia. The distinct effects of EGFR and IL-13 inhibitors after viral reprogramming suggest that these combined therapeutic strategies may also correct epithelial architecture in the setting of airway inflammatory disorders characterized by a similar pattern of chronic EGFR activation, IL-13 expression, and ciliated-to-goblet cell metaplasia

Disney animated movies, their princesses, and everyone else

In April 2021, The Walt Disney Company (Disney) announced the Ultimate Princess Celebration, ‘a year-long event spotlighting the courage and kindness these Disney heroines inspire in fans all around the world’ (Deitchman, 2021). Princesses have remained an important element of Disney’s identity and the movies they create. Broadening research beyond these characters and examining a larger sample demonstrated distinctions in the characteristics present in Official Disney Princess (ODP) movies, Actual Princess (AP) movies, and the 45 in the full catalog (All-Movies) that are or share characteristics with Disney Princess Movies. This article compares the race, class, and gender of the protagonist and antagonist as well as other story elements of 45 animated or partially animated movies that typify Disney’s ‘Classics Period’ between 1937 and 2017 across those three groups. This work examines the ways in which the ODP and AP are different from the overall catalog and violate some of the Disney norms to which we are accustomed while fully embracing others. The research found that while the Official Princess movies had more racial diversity in the main characters than the overall catalog, for example, they also had more stereotypical female villains, more magic, and more romance. Acknowledging these divisions can lead to more robust research where a research sample can be critically collected based on the topic of interest. This article provides a foundation for those examinations

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.

Most MPN patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear. To identify kinases important for survival of CALR-mutant cells we developed a novel strategy (KISMET) which utilises the full range of kinase selectivity data available from each inhibitor and thus takes advantage of off-target noise that limits conventional siRNA or inhibitor screens. KISMET successfully identified known essential kinases in haematopoietic and non-haematopoietic cell lines and identified the MAPK pathway as required for growth of the CALR-mutated MARIMO cells. Expression of mutant CALR in murine or human haematopoietic cell lines was accompanied by MPL-dependent activation of MAPK signalling, and MPN patients with CALR mutations showed increased MAPK activity in CD34-cells, platelets and megakaryocytes. Although CALR mutations resulted in protein instability and proteosomal degradation, mutant CALR was able to enhance megakaryopoiesis and pro-platelet production from human CD34+ progenitors. These data link aberrant MAPK activation to the MPN phenotype and identify it as a potential therapeutic target in CALR-mutant positive MPNs.Leukemia accepted article preview online, 14 October 2016. doi:10.1038/leu.2016.280.Work in the Green lab is supported by Leukemia and Lymphoma Research, Cancer Research UK, the NIHR Cambridge Biomedical Research Centre, the Cambridge Experimental Cancer Medicine Centre and the Leukemia & Lymphoma Society of America. WW is supported by the Austrian Science Foundation (J 3578-B21). CGA is supported by Kay Kendall Leukaemia Fund clinical research fellowship. UM is supported by a Cancer Research UK Clinician Scientist Fellowship. Work in the Huntly lab is supported by the European Research Council, the MRC (UK), Bloodwise, the Cambridge NIHR funded BRC, KKLF and a WT/MRC Stem Cell centre grant. Work in the Green and Huntly Labs is supported by core support grants by the Wellcome Trust to the Cambridge Institute for Medical Research (100140/z/12/z) and Wellcome Trust-MRC Cambridge Stem Cell Institute (097922/Z/11/Z)

More than the Renaissance: The Reclassification of the Disney Animated Films of the Classics Period

Over the past ten years, more than 200 peer-reviewed articles with Disney in their titles have been published across disciplines, especially in the humanities and social sciences. Beginning in the 1930s with Disney’s first motion picture, the company, its venues, acquisitions, movies, and other products have become a robust research topic for academics, constantly refreshed with new ideas and perspectives. As Disney celebrates its 100th anniversary in 2023, researchers and readers examining the movies could benefit from some consistency in how the passage of time is described, and yet the methods of classification of these movies are not robust or universally implemented. In this era of culture wars, how Disney has changed over time has become a political litmus test. A common vocabulary supports the claims made by defenders and detractors. This article will provide a foundation for future Disney research across disciplines on a variety of topics through a categorization and organizing system to define a context, an essence – what the movies are – and an impression – what the movies “feel like.” This structure could also be used to create consistent categories of time to measure cultural changes in other popular media longitudinally