Clinical submission of supernumerary head of adducter brevis muscle

Adductor brevis is an important member of the adductor family occupying the medial compartment of the thigh executing the function of adduction and medial rotation. Deviations from normal anatomy are unusual and rarely reported. A survey of anatomical archives revealed occasional mention of additional bellies of adductor brevis muscle. The present study reports a double belly of adductor brevis muscle (AB) found during a cadaveric dissection class for medical students. The left sided AB displayed two bellies disposed in the same plane. This case report attempts to present the clinical applications of supernumerary bellies of this important adductor muscle of the thigh. It is feasible to categorize these muscular variations upon specialized radiological procedures such as CT and MRI scans only if the radiologist possesses satisfactory understanding of variant anatomy of this region. It is thereafter inferred that upon recognition these muscles present a fair chance of being of utilitised in reconstructions. A biomechanical overview of the present anomaly is also attempte

The Spectral Energy Distribution and Infrared Luminosities of z ≈ 2 Dust-obscured Galaxies from Herschel and Spitzer

Dust-obscured galaxies (DOGs) are a subset of high-redshift (z ≈ 2) optically-faint ultra-luminous infrared galaxies (ULIRGs, e.g., L_(IR) > 10^(12) L_☉). We present new far-infrared photometry, at 250, 350, and 500 μm (observed-frame), from the Herschel Space Telescope for a large sample of 113 DOGs with spectroscopically measured redshifts. Approximately 60% of the sample are detected in the far-IR. The Herschel photometry allows the first robust determinations of the total infrared luminosities of a large sample of DOGs, confirming their high IR luminosities, which range from 10^(11.6) L_☉ 10^(13) L_☉. The rest-frame near-IR (1-3 μm) spectral energy distributions (SEDs) of the Herschel-detected DOGs are predictors of their SEDs at longer wavelengths. DOGs with "power-law" SEDs in the rest-frame near-IR show observed-frame 250/24 μm flux density ratios similar to the QSO-like local ULIRG, Mrk 231. DOGs with a stellar "bump" in their rest-frame near-IR show observed-frame 250/24 μm flux density ratios similar to local star-bursting ULIRGs like NGC 6240. None show 250/24 μm flux density ratios similar to extreme local ULIRG, Arp 220; though three show 350/24 μm flux density ratios similar to Arp 220. For the Herschel-detected DOGs, accurate estimates (within ~25%) of total IR luminosity can be predicted from their rest-frame mid-IR data alone (e.g., from Spitzer observed-frame 24 μm luminosities). Herschel-detected DOGs tend to have a high ratio of infrared luminosity to rest-frame 8 μm luminosity (the IR8 = L_(IR)(8-1000 μm)/νL_ν(8 μm) parameter of Elbaz et al.). Instead of lying on the z = 1-2 "infrared main sequence" of star-forming galaxies (like typical LIRGs and ULIRGs at those epochs) the DOGs, especially large fractions of the bump sources, tend to lie in the starburst sequence. While, Herschel-detected DOGs are similar to scaled up versions of local ULIRGs in terms of 250/24 μm flux density ratio, and IR8, they tend to have cooler far-IR dust temperatures (20-40 K for DOGs versus 40-50 K for local ULIRGs) as measured by the rest-frame 80/115 μm flux density ratios (e.g., observed-frame 250/350 μm ratios at z = 2). DOGs that are not detected by Herschel appear to have lower observed-frame 250/24 μm ratios than the detected sample, either because of warmer dust temperatures, lower IR luminosities, or both

Tubular Surface Evolution for Segmentation of the Cingulum Bundle From DW-MRI

Presented at the 2nd MICCAI Workshop on Mathematical Foundations of Computational Anatomy: Geometrical and Statistical Methods for Biological Shape Variability Modeling, September 6th, 2008, Kimmel Center, New York, USA.This work provides a framework for modeling and extracting the Cingulum Bundle (CB) from Diffusion-Weighted Imagery (DW-MRI) of the brain. The CB is a tube-like structure in the brain that is of potentially of tremendous importance to clinicians since it may be helpful in diagnosing Schizophrenia. This structure consists of a collection of fibers in the brain that have locally similar diffusion patterns, but vary globally. Standard region-based segmentation techniques adapted to DW-MRI are not suitable here because the diffusion pattern of the CB cannot be described by a global set of simple statistics. Active surface models extended to DW-MRI are not suitable since they allow for arbitrary deformations that give rise to unlikely shapes, which do not respect the tubular geometry of the CB. In this work, we explicitly model the CB as a tube-like surface and construct a general class of energies defined on tube-like surfaces. An example energy of our framework is optimized by a tube that encloses a region that has locally similar diffusion patterns, which differ from the diffusion patterns immediately outside. Modeling the CB as a tube-like surface is a natural shape prior. Since a tube is characterized by a center-line and a radius function, the method is reduced to a 4D (center-line plus radius) curve evolution that is computationally much less costly than an arbitrary surface evolution. The method also provides the center-line of CB, which is potentially of clinical significance

Effect of three decade long application of chemical fertilizer and amendments on crop yield under maize - wheat cropping system in an acid alfisol

The results on the effect of three decade long term application of chemical fertilizers and amendments on the yield of continuous maize-wheat crop rotation in an acid alfisol at Palampur revealed that continuous omission of essential nutrients in a maize-wheat sequence resulted in an appreciable decline in the grain yield of maize and wheat crops. A remarkable reduction in crop yield was noticed in plots where nitrogen was applied alone. Use of recommended level of N alone through urea had deleterious effect on crop productivity. The continuous exhaustionof native pools of K in 100% NP treated plots appreciably reduced percent grain yield. Application of farmyard manure (FYM) and lime along with NPK fertilizers increased the crop yield. The integrated use of optimal dose of NPK and FYM give better and more sustainable yields

HMDSAD: Hindi multi-domain sentiment aware dictionary

Sentiment Analysis is a fast growing sub area of Natural Language Processing which extracts user's opinion and classify it according to its polarity into positive, negative or neutral classes. This task of classification is required for many purposes like opinion mining, opinion summarization, contextual advertising and market analysis but it is domain dependent. The words used to convey sentiments in one domain is different from the words used to express sentiments in other domain and it is a costly task to annotate the corpora in every possible domain of interest before training the classifier for the classification. We are making an attempt to solve this problem by creating a sentiment aware dictionary using multiple domain data. The source domain data is labeled into positive and negative classes at the document level and the target domain data is unlabeled. The dictionary is created using both source and target domain data. The words used to express positive or negative sentiments in labeled data has relatedness weights assigned to it which signifies its co-occurrence frequency with the words expressing the similar sentiments in target domain. This work is carried out in Hindi, the official language of India. The web pages in Hindi language is booming very quickly after the introduction of UTF-8 encoding style. The dictionary can be used to classify the unlabeled data in the target domain by training a classifier

Utility of patient-derived lymphoblastoid cell lines as an ex vivo capecitabine sensitivity prediction model for breast cancer patients.

Capecitabine is commonly used in treating breast cancer; however, therapeutic response varies among patients and there is no clinically validated model to predict individual outcomes. Here, we investigated whether drug sensitivity quantified in ex vivo patients' blood-derived cell lines can predict response to capecitabine in vivo. Lymphoblastoid cell lines (LCLs) were established from a cohort of metastatic breast cancer patients (n = 53) who were prospectively monitored during treatment with single agent capecitabine at 2000 mg/m2/day. LCLs were treated with increasing concentrations of 5'-DFUR, a major capecitabine metabolite, to assess patients' ex vivo sensitivity to this drug. Subsequently, ex vivo phenotype was compared to observed patient disease response and drug induced-toxicities. We acquired an independent cohort of breast cancer cell lines and LCLs derived from the same donors from ATCC, compared their sensitivity to 5'-DFUR. As seen in the patient population, we observed large inter-individual variability in response to 5'-DFUR treatment in patient-derived LCLs. Patients whose LCLs were more sensitive to 5'-DFUR had a significantly longer median progression free survival (9-month vs 6-month, log rank p-value = 0.017). In addition, this significant positive correlation for 5'-DFUR sensitivity was replicated in an independent cohort of 8 breast cancer cell lines and LCLs derived from the same donor. Our data suggests that at least a portion of the individual sensitivity to capecitabine is shared between germline tissue and tumor tissue. It also supports the utility of patient-derived LCLs as a predictive model for capecitabine treatment efficacy in breast cancer patients

Spitzer Mid-Infrared Spectroscopy of 70um-Selected Distant Luminous Infrared Galaxies

We present mid-infrared spectroscopy obtained with the Spitzer Space Telescope of a sample of 11 optically faint, infrared luminous galaxies selected from a Spitzer MIPS 70um imaging survey of the NDWFS Bootes field. These are the first Spitzer IRS spectra presented of distant 70um-selected sources. All the galaxies lie at redshifts 0.3<z<1.3 and have very large infrared luminosities of L_IR~ 0.1-17 x 10^12 solar luminosities. Seven of the galaxies exhibit strong emission features attributed to polycyclic aromatic hydrocarbons (PAHs). The average IRS spectrum of these sources is characteristic of classical starburst galaxies, but with much larger infrared luminosities. The PAH luminosities of L(7.7) ~ 0.4 - 7 x 10^11 solar luminosities imply star formation rates of ~ 40 - 720 solar masses per year. Four of the galaxies show deep 9.7um silicate absorption features and no significant PAH emission features (6.2um equivalent widths < 0.03um). The large infrared luminosities and low f70/f24 flux density ratios suggests that these sources have AGN as the dominant origin of their large mid-infrared luminosities, although deeply embedded but luminous starbursts cannot be ruled out. If the absorbed sources are AGN-dominated, a significant fraction of all far-infrared bright, optically faint sources may be dominated by AGN.Comment: 8 Pages, ApJ accepte