Exploiting the Design Freedom of RM

This paper details how Rapid Manufacturing (RM) can overcome the restrictions imposed by the inherent process limitations of conventional manufacturing techniques and become the enabling technology in fabricating optimal products. A new design methodology capable of exploiting RM’s increased design freedom is therefore needed. Inspired by natural world structures of trees and bones, a multi-objective, genetic algorithm based topology optimisation approach is presented. This combines multiple unit cell structures and varying volume fractions to create a heterogeneous part structure which exhibits a uniform stress distribution.Mechanical Engineerin

The SBI Program and Student Outcomes: A Study of Business Policy Classes

This study represents a preliminary inquiry ID to determine the value of combining SBI and Policy into a singular curriculum. A comparison of this combined formal was made wi1h the traditional Policy course. A slightly modified Job Diagnostic Survey (Hackman & Oldham, 1975) and a skills/usefulness scale (Hoffman, Fon1eno1 & Viswanathan, 1990) was administered to assess the difference between the two groups. Results suggested that the combined format met or exceeded the ou1comes of the traditional Policy course

Silencing disease genes in the laboratory and the clinic

Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before their full impact on patient care can be understood. Antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) are the two most widely used strategies for silencing gene expression. We first describe these two approaches and contrast their relative strengths and weaknesses for laboratory applications. We then review the choices faced during development of clinical candidates and the current state of clinical trials. Attitudes towards clinical development of nucleic acid silencing strategies have repeatedly swung from optimism to depression during the past 20 years. Our goal is to provide the information needed to design robust studies with oligonucleotides, making use of the strengths of each oligonucleotide technology

A new genus and species of cryptocephaline leaf beetle (Coleoptera: Chrysomelidae) from Costa Rica

Aulacothoracicus coastaricensis Watts, new genus and new species of cryoptocephaline Chrysomelidae, is described from Costa Rica. Illustrations and an updated key to the genera of the subfamily in North and Central America are provided

Topological structures in the equities market network

We present a new method for articulating scale-dependent topological descriptions of the network structure inherent in many complex systems. The technique is based on "Partition Decoupled Null Models,'' a new class of null models that incorporate the interaction of clustered partitions into a random model and generalize the Gaussian ensemble. As an application we analyze a correlation matrix derived from four years of close prices of equities in the NYSE and NASDAQ. In this example we expose (1) a natural structure composed of two interacting partitions of the market that both agrees with and generalizes standard notions of scale (eg., sector and industry) and (2) structure in the first partition that is a topological manifestation of a well-known pattern of capital flow called "sector rotation.'' Our approach gives rise to a natural form of multiresolution analysis of the underlying time series that naturally decomposes the basic data in terms of the effects of the different scales at which it clusters. The equities market is a prototypical complex system and we expect that our approach will be of use in understanding a broad class of complex systems in which correlation structures are resident.Comment: 17 pages, 4 figures, 3 table

Towards scalable end-to-end QoS provision for VoIP applications

The growth of the Internet and the development of its new applications have increased the demand for providing a certain level of resource assurance and service support. The concept of ensuring quality of service (QoS) has been introduced in order to provide the support and assurance for these services. Different QoS mechanisms, such as integrated services (IntServ) and differentiated services (DiffServ), have been developed and introduced to provide different levels of QoS provision. However, IntServ can suffer from scalability issues that make it infeasible for large-scale network implementations. On the other hand, the aggregated-based per-flow technique of DiffServ does not provide such an end-to-end QoS guarantee. Recently, the IETF have proposed a new QoS architecture that implements IntServ over DiffServ in order to provide an end-to-end QoS for scalable networks. Hence, it became possible to provide and support a certain level of QoS for some delay sensitive and bandwidth-demanding applications such as voice over Internet Protocol (VoIP). With regard to VoIP applications, delay, jitter and packet loss are crucial issues that have to be taken into consideration for any VoIP system design and such parameters need a distinct level of QoS support

Forebody and vertical stabilizer effects on directional stability of a reusable LOX/RP (061) booster AR 12161-2

Results are presented of a wind tunnel test on the directional stability of space shuttle booster configurations. The test was conducted at the 14-inch trisonic tunnel starting 6 December 1971 and continued through 11 December 1971 for a total of 66 occupancy hours. Configurations tested included a cylindrical body with two axisymmetrical noses, one with and without canopy, one delta wing, located in two positions, five vertical tails (including a V tail), two having split rudders, ventral fins, two sets of chines, three airbreathing engine pods, and rocket engine shrouds. The model scale was 0.003366

Examination of a culturable microbial population from the gastrointestinal tract of the wood-eating loricariid catfish Panaque nigrolineatus

Fish play a critical role in nutrient cycling and organic matter flow in aquatic environments. However, little is known about the microbial diversity within the gastrointestinal tracts that may be essential in these degradation activities. Panaque nigrolineatus is a loricariid catfish found in the Neotropics that have a rare dietary strategy of consuming large amounts of woody material in its natural environment. As a consequence, the gastrointestinal (GI) tract of P. nigrolineatus is continually exposed to high levels of cellulose and other recalcitrant wood compounds and is, therefore, an attractive, uncharacterized system to study microbial community diversity. Our previous 16S rRNA gene surveys demonstrated that the GI tract microbial community includes phylotypes having the capacity to degrade cellulose and fix molecular nitrogen. In the present study we verify the presence of a resident microbial community by fluorescence microscopy and focus on the cellulose-degrading members by culture-based and 13C-labeled cellulose DNA stable-isotope probing (SIP) approaches. Analysis of GI tract communities generated from anaerobic microcrystalline cellulose enrichment cultures by 16S rRNA gene analysis revealed phylotypes sharing high sequence similarity to known cellulolytic bacteria including Clostridium, Cellulomonas, Bacteroides, Eubacterium and Aeromonas spp. Related bacteria were identified in the SIP community, which also included nitrogen-fixing Azospirillum spp. Our ability to enrich for specialized cellulose-degrading communities suggests that the P. nigrolineatus GI tract provides a favorable environment for this activity and these communities may be involved in providing assimilable carbon under challenging dietary conditions

Hypersonic structures: An aerodynamicist's perspective, or one man's dream is another man's nightmare

The relationship between hypersonic aerodynamic and structural design is reviewed. The evolution of the hypersonic vehicle design is presented. Propulsion systems, structural materials, and fuels are emphasized