Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium flabelliforme against Several Cancer Cell Lines

The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents

The depositional history of an esker near Ottawa, Canada

The 10 km long Stittsville Ridge, trending parallel to the last direction of ice advance into the Ottawa area, is here classified as an esker. The sediments of the ridge are interpreted as subaqueous outwash deposited from a subglacial or englacial meltwater conduit emptying into an inlet in the late Wisconsin glacier front. The ridge formed by the coalescence of subaqueous outwash fans as the ice retreated northward. Sedimentological variation along the ridge is attributed to a change in the morphology of the inlet as the ice front retreated, from an initially narrow, symmetrical shape to a broader and increasingly asymmetrical form. </jats:p

The Cypress Hills Formation (Upper Eocene to Miocene): a semi-arid braidplain deposit resulting from intrusive uplift

The Upper Eocene – Miocene Cypress Hills Formation of the Cypress Hills plateau, in southwestern Saskatchewan and southeastern Alberta, is interpreted as a braidplain deposit. The regional paleoslope dipped to the northeast, and the east–west distribution of outcrop exposes facies representing lateral variation across the slope of the braidplain. Overall, the average clast size of the deposits decreases from west to east, with western area sediments dominated by boulder-sized gravels deposited on longitudinal bars. The eastern outcrop area contains deposits of braided channels cut into and interbedded with finer interchannel material including lacustrine marlstones, silcretes, and debris-flow deposits, the latter commonly containing abundant fossils.The gravels of the Cypress Hills Formation are multicyclic; they were originally derived from the western ranges of the Rocky Mountains during Laramide orogenesis and later shed farther into the basin during rebound due to unloading of the Laramide thrusts by erosion. Most recent transport resulted from uplift by intrusive activity of the Sweetgrass Hills, the Bearpaw Mountains, and the Highwood Mountains in northern Montana. Transport from the uplifted source areas was largely restricted to valley-confined rivers with the braidplains beginning beyond the valley termini. The lateral extent of the gravel braidplain was limited by the position of valleys and resulted in the observed variation in facies. Climate, as indicated by the sedimentology, faunal assemblages, silcretes, and palynology, was semi-arid with seasonal rainfall. </jats:p