Test of the photon detection system for the LHCb RICH Upgrade in a charged particle beam

© CERN 2017 for the benefit of the LHCb collaboration. The LHCb detector will be upgraded to make more efficient use of the available luminosity at the LHC in Run III and extend its potential for discovery. The Ring Imaging Cherenkov detectors are key components of the LHCb detector for particle identification. In this paper we describe the setup and the results of tests in a charged particle beam, carried out to assess prototypes of the upgraded opto-electronic chain from the Multi-Anode PMT photosensor to the readout and data acquisition system

Rescue of replication failure by Fanconi anaemia proteins

Chromosomal aberrations are often associated with incomplete genome duplication, for instance at common fragile sites, or as a consequence of chemical alterations in the DNA template that block replication forks. Studies of the cancer-prone disease Fanconi anaemia (FA) have provided important insights into the resolution of replication problems. The repair of interstrand DNA crosslinks induced by chemotherapy drugs is coupled with DNA replication and controlled by FA proteins. We discuss here the recent discovery of new FA-associated proteins and the development of new tractable repair systems that have dramatically improved our understanding of crosslink repair. We focus also on how FA proteins protect against replication failure in the context of fragile sites and on the identification of reactive metabolites that account for the development of Fanconi anaemia symptoms

Low-noise front-end amplifier and channel encoder for a 2-D X-ray digital imaging system with single photon counting capability

We describe two VLSI CMOS ICs for 2-D X-ray digital imaging systems with single photon counting capability: a low noise front-end analog amplifier and an 80 MHz synchronous digital encoder. Our VLSI system will be optimized to perform X-Y coincidences with double-sided microstrip digital detector. The main application we are investigating is stereotaxic mammography, because of low X-ray energy used and the small area involved. (C) 2001 Published by Elsevier Science B.V

A new electronic read-out for the YAPPET scanner

A small animal PET-SPECT scanner (YAPPET) prototype was built at the Physics Department of the Ferrara University and is presently being used at the Nuclear Medicine Department for radiopharmaceutical studies on rats. The first YAPPET prototype shows very good performances, but needs some improvements before it can be fully used for intensive radiopharmaceutical research. The main problem of the actual prototype is its heavy electronics, based on NIM and CAMAC standard modules. For this reason a new, compact read-out electronics was developed and tested. The results of a first series of tests made on the first prototype will be presented in the paper. (C) 2002 Elsevier Science B.V. All rights reserved

A Fast and Radiation-Hard Single-Photon Counting ASIC for the Upgrade of the LHCb RICH Detector at CERN

A new version of the CLARO8 ASIC has been designed in AMS 0.35 mu m CMOS technology, based on radiation hardened by design cells, and extensively tested. Results on the complete radiation hardness characterization are presented