Challenges to the development of antigen-specific breast cancer vaccines

Continued progress in the development of antigen-specific breast cancer vaccines depends on the identification of appropriate target antigens, the establishment of effective immunization strategies, and the ability to circumvent immune escape mechanisms. Methods such as T cell epitope cloning and serological expression cloning (SEREX) have led to the identification of a number target antigens expressed in breast cancer. Improved immunization strategies, such as using dendritic cells to present tumor-associated antigens to T lymphocytes, have been shown to induce antigen-specific T cell responses in vivo and, in some cases, objective clinical responses. An outcome of successful tumor immunity is the evolution of antigen-loss tumor variants. The development of a polyvalent breast cancer vaccine, directed against a panel of tumor-associated antigens, may counteract this form of immune escape

Study of Bc+B_c^+ decays to the K+K−π+K^+K^-\pi^+ final state and evidence for the decay Bc+→χc0π+B_c^+\to\chi_{c0}\pi^+

A study of $B_c^+\to K^+K^-\pi^+$ decays is performed for the first time using data corresponding to an integrated luminosity of 3.0 $\mathrm{fb}^{-1}$ collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of $7$ and $8$ TeV. Evidence for the decay $B_c^+\to\chi_{c0}(\to K^+K^-)\pi^+$ is reported with a significance of 4.0 standard deviations, resulting in the measurement of $\frac{\sigma(B_c^+)}{\sigma(B^+)}\times\mathcal{B}(B_c^+\to\chi_{c0}\pi^+)$ to be $(9.8^{+3.4}_{-3.0}(\mathrm{stat})\pm 0.8(\mathrm{syst}))\times 10^{-6}$. Here $\mathcal{B}$ denotes a branching fraction while $\sigma(B_c^+)$ and $\sigma(B^+)$ are the production cross-sections for $B_c^+$ and $B^+$ mesons. An indication of $\bar b c$ weak annihilation is found for the region $m(K^-\pi^+)<1.834\mathrm{\,Ge\kern -0.1em V\!/}c^2$, with a significance of 2.4 standard deviations.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-022.html, link to supplemental material inserted in the reference

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT

Observation of Bc+ →j /ψD (∗)K (∗) decays

A search for the decays B+c→J/ψD(*)0K+ and B+c→J/ψD(*)+K*0 is performed with data collected at the LHCb experiment corresponding to an integrated luminosity of 3 fb−1. The decays B+c→J/ψ0K+ and B+c→J/ψD*0K+ are observed for the first time, while first evidence is reported for the B+c→JψD*+K*0 and B+c→J/ψD+K*0 decays. The branching fractions of these decays are determined relative to the B+c→J/ψπ+ decay. The B+c mass is measured, using the J/ψD0K+ final state, to be 6274.28±1.40(stat)±0.32(syst) MeV/c2. This is the most precise single measurement of the B+c mass to date

Measurement of CP violation parameters in B-0 -> DK*(0) decays

An analysis of B-0 --> DK*(0) decays is presented, where D represents an admixture of D-0 and (D) over bar (0) mesons reconstructed in four separate final states: K-pi(+), pi K--(+), K+K- and pi(+)pi(-). The data sample corresponds to 3.0 fb(-1) of proton-proton collision, collected by the LHCb experiment. Measurements of several observables are performed, including CP asymmetries. The most precise determination is presented of r(B)(DK*(0)), the magnitude of the ratio of the amplitudes of the decay B-0 --> DK+pi(-) with a b --> u or a b --> c transition, in a K pi mass region of +/- 50 MeV/c(2) around the K*(892) mass and for an absolute value of the cosine of the K*(0) helicity angle larger than 0.4

Precision Measurement of the Mass and Lifetime of the Xi(-)(b) Baryon

We report on measurements of the mass and lifetime of the Xi(-)(b) baryon using about 1800 Xi(-)(b) decays reconstructed in a proton-proton collision data set corresponding to an integrated luminosity of 3.0 fb(-1) collected by the LHCb experiment. The decays are reconstructed in the Xi(-)(b) -> Xi(0)(c)pi(-), Xi(0)(c) -> pK(-)K(-)pi(+) channel and the mass and lifetime are measured using the Lambda(0)(b) -> Lambda(+)(c)pi(-) mode as a reference. We measure M(Xi(-)(b)) ¿ M(Lambda(0)(b)) = 178.36 +/- 0.46 +/- 0.16 MeV/c(2), (tau Xi(-)(b)/tau Lambda(0)(b)) = 1.089 +/- 0.026 +/- 0.011, where the uncertainties are statistical and systematic, respectively. These results lead to a factor of 2 better precision on the Xi(-)(b) mass and lifetime compared to previous best measurements, and are consistent with theoretical expectations

First Observation of a Baryonic B-c(+) Decay

A baryonic decay of the B-c(+) meson, B-c(+) -> J/psi p (p) over bar pi(+) is observed for the first time, with a significance of 7.3 standard deviations, in pp collision data collected with the LHCb detector and corresponding to an integrated luminosity of 3.0 fb(-1) taken at center-of-mass energies of 7 and 8 TeV. With the B-c(+) -> J/psi pi(+) decay as the normalization channel, the ratio of branching fractions is measured to be B(B-c(+) -> J/psi p (p) over bar pi(+)) /B(B-c(+) -> J/psi pi(+)) = 0.143(-0.034)(+0.039) (stat) +/- 0.013 (syst). The mass of the B-c(+) messon is determined as M(B-c(+)) = 6274.0 +/- 0.4 (sysst) MeV/c(2), using the B-c(+) -> J/psi p (p) over bar pi(+) channel

Measurement of CP asymmetry in B-s(0) -> D-s(-/+) K-/+ decays

We report on measurements of the time-dependent CP violating observables in B-s(0) -> D-s(-/+) K--/+ decays using a dataset corresponding to 1.0 fb(-1) of pp collisions recorded with the LHCb detector. We find the CP violating observables C-f = 0.53 +/- 0.25 +/- 0.04, A(f)(Delta Gamma) = 0.37 +/- 0.42 +/- 0.20, A((f) over bar)(Delta Gamma) = 0.20 +/- 0.41 +/- 0.20, S-f = -1.09 +/- 0.33 +/- 0.08, S-(f) over bar = -0.36 +/- 0.34 +/- 0.08, where the uncertainties are statistical and systematic, respectively. Using these observables together with a recent measurement of the B-s(0) mixing phase -2 beta(s) leads to the first extraction of the CKM angle gamma from B-s(0) -> D-s(-/+) K--/+ decays, finding gamma = (115(-43)(+28))degrees modulo 180 degrees at 68% CL, where the error contains both statistical and systematic uncertainties

Measurements of CP violation in the three-body phase space of charmless B-+/- decays

The charmless three- body decay modes B +/- -> K +/-pi(-)pi(-), B-+/- -> K-+/- (KK-)-K-+/-, B-+/- pi(-) K-K- and B-+/-pi(-)pi(-) are reconstructed using data, corresponding to an integrated luminosity of 3.0 fb(-1), collected by the LHCb detector. The inclusive CP asymmetries of these modes are measured to be [GRAPHICS] where the first uncertainty is statistical, the second systematic, and the third is due to the CP asymmetry of the B +/- J Psi K-+/- reference mode. The distributions of these asymmetries are also studied as functions of position in the Dalitz plot and suggest contributions from rescattering and resonance interference processes

First Observation of a Baryonic B-c(+) Decay

A baryonic decay of the $B_c^+$ meson, $B_c^+\to J/\psi p\overline{p}\pi^+$, is observed for the first time, with a significance of $7.3$ standard deviations, in $pp$ collision data collected with the LHCb detector and corresponding to an integrated luminosity of $3.0$ fb$^{-1}$ taken at center-of-mass energies of $7$ and $8$ $\mathrm{TeV}$. With the $B_c^+\to J/\psi \pi^+$ decay as normalization channel, the ratio of branching fractions is measured to be \begin{equation*} \frac{\mathcal{B}(B_c^+\to J/\psi p\overline{p}\pi^+)}{\mathcal{B}(B_c^+\to J/\psi \pi^+)} = 0.143^{\,+\,0.039}_{\,-\,0.034}\,(\mathrm{stat})\pm0.013\,(\mathrm{syst}). \end{equation*} The mass of the $B_c^+$ meson is determined as $M(B_c^+)=6274.0\pm1.8\,(\mathrm{stat})\pm0.4\,(\mathrm{syst})\,\mathrm{MeV}/c^2$, using the $B_c^+\to J/\psi p\overline{p}\pi^+$ channel.Comment: 20 pages, 2 figure