Optomechanical characterization of acoustic modes in a mirror

We present an experimental study of the internal mechanical vibration modes of a mirror. We determine the frequency repartition of acoustic resonances via a spectral analysis of the Brownian motion of the mirror, and the spatial profile of the acoustic modes by monitoring their mechanical response to a resonant radiation pressure force swept across the mirror surface. We have applied this technique to mirrors with cylindrical and plano-convex geometries, and compared the experimental results to theoretical predictions. We have in particular observed the gaussian modes predicted for plano-convex mirrors.Comment: 8 pages, 8 figures, RevTe

Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample

We obtained conclusive linkage of Alzheimer disease (AD) with a candidate region of 19.7 cM at 7q36 in an extended multiplex family, family 1270, ascertained in a population-based study of early-onset AD in the northern Netherlands. Single-nucleotide polymorphism and haplotype association analyses of a Dutch patient-control sample further supported the linkage at 7q36. In addition, we identified a shared haplotype at 7q36 between family 1270 and three of six multiplex AD-affected families from the same geographical region, which is indicative of a founder effect and defines a priority region of 9.3 cM. Mutation analysis of coding exons of 29 candidate genes identified one linked synonymous mutation, g.38030G-->C in exon 10, that affected codon 626 of the PAX transactivation domain interacting protein gene (PAXIP1). It remains to be determined whether PAXIP1 has a functional role in the expression of AD in family 1270 or whether another mutation at this locus explains the observed linkage and sharing. Together, our linkage data from the informative family 1270 and the association data in the population-based early-onset AD patient-control sample strongly support the identification of a novel AD locus at 7q36 and re-emphasize the genetic heterogeneity of AD

Effect Of Salivary Contamination At Different Steps Of The Bonding Process On The Microleakage Around Class V Restorations

This study aimed to investigate the influence of the moment of salivary contamination during the bonding procedure (before or after acid conditioning) on the microleakage around composite resin restorations. Sixty bovine incisors received two Class V preparations (one with dentin margins and other with enamel margins). Teeth were randomly assigned into three, groups (n-20): 1) control (not contaminated); 2) salivary contamination before etching with 34% phosphoric acid; and, 3) salivary contamination after acid etching. Cavities were restored using Prime & Bond NT (Dentsply) adhesive system and TPH Spectrum (Dentsply) composite according to manufacturer instructions. Teeth were thermocycled (500x, 5-55°C, 60s/bath), immersed in 2% methylenee blue buffered solution (pH 7.0), and sectioned into two halves. Three examiners measured the extent of dye penetration or dentin and enamel margins in a stereoscope microscope, using four representative scores. Statistical analysis were performed with Kruskal-Wallis/Wilcoxon tests (α-5%). The results showed that enamel and dentin margins did not present significant differences (p>0.05). However, significantly higher dye penetration was observed on substrates etched and further contaminated with saliva. It was concluded that salivary contamination after acid etching increases the microleakage around composite resin restorations, especially at dentin margins. However, acid etching subsequent to the contamination can avoid negative effects on restorations margins.62314451449Van Meerbeek, B., Van Landuyt, K., De Munck, J., Hashimoto, M., Peumans, M., Lambrechts, P., Technique -sensitivity of contemporary adhesives (2005) Dent Mater J, 24, pp. 1-13Civelek, A., Ersoy, M., L'Hotelier, E., Soyman, M., Say, E.C., Polymerization shrinkage and microleakage in Class II cavities of various resin composites (2003) Oper Dent, 28, pp. 635-641Besnault, C., Attal, J.P., Influence of a simulated oral environment on microleakage of two adhesive systems in Class II composite restorations (2002) J Dent, 30, pp. 1-6Spencer, P., Wang, Y., Bohaty, B., Interfacial chemistry of moisture-aged class II composite restorations (2006) J Biomed Mater Res B Appl Biomater, 77, pp. 234-240Direct and indirect restorative materials (2003) J Am Dent Assoc, 134, pp. 463-472. , Council on Scientific Affairs ADASoldani, F., Foley, J., An assessment of rubber dam usage amongst specialists in paediatric dentistry practising within the UK (2007) Int J Paediatr Dent, 17, pp. 50-56Fernandes, A.S., Rodrigues, S., Singhal, K., Murthi, M.S., Assessment of chair side techniques for composite resin restoration - a survey (2003) Indian J Dent Res, 14, pp. 47-56Taskonak, B., Sertgoz, A., Shear bond strengths of saliva contaminated 'one-bottle' adhesives (2002) J Oral Rehabil, 29, pp. 559-564Eiriksson, S.O., Pereira, P.N., Swift Jr., E.J., Heymann, H.O., Sigurdsson, A., Effects of saliva contamination on resin-resin bond strength (2004) Dent Mater, 20, pp. 37-44Hiraishi, N., Kitasako, Y., Nikaido, T., Nomura, S., Burrow, M.F., Tagami, J., Effect of artificial saliva contamination on pH value change and dentin bond strength (2003) Dent Mater, 19, pp. 429-434Park, J.W., Lee, K.C., The influence of salivary contamination on shear bond strength of dentin adhesive systems (2004) Oper Dent, 29, pp. 437-442Yoo, H.M., Oh, T.S., Pereira, P.N., Effect of saliva contamination on the microshear bond strength of one-step self-etching adhesive systems to dentin (2006) Oper Dent, 31, pp. 127-134Hitmi, L., Attal, J.P., Degrange, M., Influence of the time-point of salivary contamination on dentin shear bond strength of 3 dentin adhesive systems (1999) J Adhes Dent, 1, pp. 219-232Reis, A.F., Giannini, M., Kavaguchi, A., Soares, C.J., Line, S.R., Comparison of microtensile bond strength to enamel and dentin of human, bovine, and porcine teeth (2004) J Adhes Dent, 6, pp. 117-121Eiriksson, S.O., Pereira, P.N., Swift, E.J., Heymann, H.O., Sigurdsson, A., Effects of blood contamination on resin-resin bond strength (2004) Dent Mater, 20, pp. 184-190Toledano, M., Osorio, R., Ceballos, L., Fuentes, M.V., Fernandes, C.A., Tay, F.R., Microtensile bond strength of several adhesive systems to different dentin depths (2003) Am J Dent, 16, pp. 292-29

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Svestka's Research: Then and Now

Zdenek Svestka's research work influenced many fields of solar physics, especially in the area of flare research. In this article I take five of the areas that particularly interested him and assess them in a "then and now" style. His insights in each case were quite sound, although of course in the modern era we have learned things that he could not readily have envisioned. His own views about his research life have been published recently in this journal, to which he contributed so much, and his memoir contains much additional scientific and personal information (Svestka, 2010).Comment: Invited review for "Solar and Stellar Flares," a conference in honour of Prof. Zden\v{e}k \v{S}vestka, Prague, June 23-27, 2014. This is a contribution to a Topical Issue in Solar Physics, based on the presentations at this meeting (Editors Lyndsay Fletcher and Petr Heinzel

Scarabaeoidea (Insecta : Coleoptera) in the Brazilian Cerrado : current state of knowledge

Besouros pertencentes à superfamília Scarabaeoidea ocupam habitats variados, possuem hábitos alimentares diversifi cados, desempenham importante papel ecológico e diversas espécies apresentam importância agrícola. No entanto, estudos com esse grupo na região do Cerrado são escassos. Nesta revisão realizou-se um levantamento dos artigos publicados nos últimos 30 anos a respeito dos Scarabaeoidea no Cerrado. Foram recuperados 64 artigos, realizados em nove unidades da federação, que focavam quatro temas principais espécies praga, aspectos bioecológicos, biodiversidade e importância ecológica, e técnicas e metodologias de coleta de Scarabaeoidea. Os resultados desta revisão indicam que poucos estudos foram realizados com os Scarabaeoidea no Cerrado brasileiro nas últimas décadas frente à importância e diversidade desse grupo de insetos.Beetles belonging to the superfamily Scarabaeoidea occupy different habitats, present feeding habits diversifi ed, play an important ecological role and several species have agricultural importance. However, studies with this group in the Brazilian Cerrado are scarce. In this review we carried out a survey of scientifi c articles published in the past 30 years concerning Scarabaeoidea in the Cerrado. Were found 64 studies in nine Brazilian states. The studies focused on four main topics: pest species, bioecology, biodiversity and ecological importance, techniques and methodologies for collecting Scarabaeoidea. The results of this review indicate that few studies have been conducted with Scarabaeoidea in the Cerrado in recent decades compared to the importance and diversity of this group of insects

Milagro limits and HAWC sensitivity for the rate-density of evaporating Primordial Black Holes

postprin

Assessing associations between the AURKAHMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers

While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood appr

Astronomical Distance Determination in the Space Age: Secondary Distance Indicators

The formal division of the distance indicators into primary and secondary leads to difficulties in description of methods which can actually be used in two ways: with, and without the support of the other methods for scaling. Thus instead of concentrating on the scaling requirement we concentrate on all methods of distance determination to extragalactic sources which are designated, at least formally, to use for individual sources. Among those, the Supernovae Ia is clearly the leader due to its enormous success in determination of the expansion rate of the Universe. However, new methods are rapidly developing, and there is also a progress in more traditional methods. We give a general overview of the methods but we mostly concentrate on the most recent developments in each field, and future expectations. © 2018, The Author(s)