Paraoxonase gene polymorphisms and haplotype analysis in a stroke population

Peer reviewedPublisher PD

Bridging flavour violation and leptogenesis in SU(3) family models

We reconsider basic, in the sense of minimal field content, Pati-Salam x SU(3) family models which make use of the Type I see-saw mechanism to reproduce the observed mixing and mass spectrum in the neutrino sector. The goal of this is to achieve the observed baryon asymmetry through the thermal decay of the lightest right-handed neutrino and at the same time to be consistent with the expected experimental lepton flavour violation sensitivity. This kind of models have been previously considered but it was not possible to achieve a compatibility among all of the ingredients mentioned above. We describe then how different SU(3) messengers, the heavy fields that decouple and produce the right form of the Yukawa couplings together with the scalars breaking the SU(3) symmetry, can lead to different Yukawa couplings. This in turn implies different consequences for flavour violation couplings and conditions for realizing the right amount of baryon asymmetry through the decay of the lightest right-handed neutrino. Also a highlight of the present work is a new fit of the Yukawa textures traditionally embedded in SU(3) family models.Comment: 26 pages, 5 figures, Some typos correcte

Recovering from stillbirth: the effects of making and sharing memories on maternal mental health

Objective: This study examined whether the experience of creating and sharing memories of their babies is associated with mothers’ mental health after stillbirth, taking account of factors previously shown to be important. Background: Mothers of stillborn babies are usually offered the opportunity to spend time with and create memories of their babies. However, evidence on whether this leads to better mental health outcomes is equivocal. One possible explanation is that the impact of making memories is mediated by the extent to which women subsequently share these memories. Methods: Cross-sectional questionnaire study. Mothers (N = 162) of stillborn babies completed online questionnaires of how memories were made and shared, satisfaction with memory-making and sharing, professional and social support, and symptoms of depression, anxiety and PTSD. Results: The majority of mothers made and shared memories. The number of different memory-making activities was not associated with mental health outcomes. However, the degree to which mothers shared their memories was associated with fewer PTSD symptoms. Regression analyses showed that good mental health was most strongly associated with time since stillbirth, perceived professional support, sharing of memories and less wish to talk more about the baby. Conclusion: This study confirms research showing that time since stillbirth and perceived professional support is associated with better mental health following stillbirth and for the first time shows the importance of opportunities to share memories of the baby. Variation in sharing opportunities may contribute to inconsistencies in the association between making memories and mental health following stillbirth

Complex patterns of local adaptation in teosinte

Populations of widely distributed species often encounter and adapt to specific environmental conditions. However, comprehensive characterization of the genetic basis of adaptation is demanding, requiring genome-wide genotype data, multiple sampled populations, and a good understanding of population structure. We have used environmental and high-density genotype data to describe the genetic basis of local adaptation in 21 populations of teosinte, the wild ancestor of maize. We found that altitude, dispersal events and admixture among subspecies formed a complex hierarchical genetic structure within teosinte. Patterns of linkage disequilibrium revealed four mega-base scale inversions that segregated among populations and had altitudinal clines. Based on patterns of differentiation and correlation with environmental variation, inversions and nongenic regions play an important role in local adaptation of teosinte. Further, we note that strongly differentiated individual populations can bias the identification of adaptive loci. The role of inversions in local adaptation has been predicted by theory and requires attention as genome-wide data become available for additional plant species. These results also suggest a potentially important role for noncoding variation, especially in large plant genomes in which the gene space represents a fraction of the entire genome

Revue d'histoire du Bas-Saint-Laurent, vol. 12 (3-4)

Mot de l'éditeur -- Au micro de CJBR -- La grande histoire de CJBR -- Jules-A. Brillant et le poste CJBR -- Avec CJBR, un bon en avant pour le Bas St-Laurent -- CJBR, l'école -- L'annonceur: un éducateur populaire -- Sandy Burgess : le journaliste que j'ai connu -- "Ce pays qui est le mien" -- Un demi-siècle d'information: que de nouvelles! -- Journaliste de père en fils à CJBR -- Le théâtre à CJBR -- 50 ans de musique à CJBR, le château fort de la mélodie française -- Poésie, théâtre, jazz et originalité avec Michel Garneau -- Les "Chroniques du dimanche", l'âge d'or de la critique culturelle à CJBR -- "Si CJBR m'était conté..." -- L'évolution technologique, un élément-clef de l'histoire des 50 ans de radiodiffusion -- La publicité à CJBR, quarante ans de croissance -- Des pionnières à CJBR -- 1958-1972, des années enrichissantes -- De Trois-Pistoles à Rimouski -- Le sport et son enracinement dans le milieu régional -- "Debout c'est l'heure", c'est Jean Brisson qui sonne le réveil -- "Par une belle journée de tempête" -- Et on repart vers la centain

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

Oral estrogen administration attenuates the metabolic action of growth hormone (GH) in humans. To investigate the mechanism involved, we studied the effects of estrogen on GH signaling through Janus kinase (JAK)2 and the signal transducers and activators of transcription (STATs) in HEK293 cells stably expressing the GH receptor (293GHR), HuH7 (hepatoma) and T-47D (breast cancer) cells. 293GHR cells were transiently transfected with an estrogen receptor-α expression plasmid and luciferase reporters with binding elements for STAT3 and STAT5 or the β-casein promoter. GH stimulated the reporter activities by four- to sixfold. Cotreatment with 17β-estradiol (E2) resulted in a dose-dependent reduction in the response of all three reporters to GH to a maximum of 49-66% of control at 100 nM (P < 0.05). No reduction was seen when E2 was added 1-2 h after GH treatment. Similar inhibitory effects were observed in HuH7 and T-47D cells. E2 suppressed GH-induced JAK2 phosphorylation, an effect attenuated by actinomycin D, suggesting a requirement for gene expression. Next, we investigated the role of the suppressors of cytokine signaling (SOCS) in E2 inhibition. E2 increased the mRNA abundance of SOCS-2 but not SOCS-1 and SOCS-3 in HEK293 cells. The inhibitory effect of E2 was absent in cells lacking SOCS-2 but not in those lacking SOCS-1 and SOCS-3. In conclusion, estrogen inhibits GH signaling, an action mediated by SOCS-2. This paper provides evidence for regulatory interaction between a sex steroid and the GH/JAK/STAT pathway, in which SOCS-2 plays a central mechanistic role

Supporting older and younger adults’ memory for recent everyday events: a prospective sampling study using SenseCam

This study measured the effect of a wearable camera, SenseCam, on older and younger adults’ memories of recently experienced everyday events. Participants used SenseCam to prospectively sample events from a typical week, which they recalled two weeks later. Recall was cued by a self-generated title only (control condition), by the title and forward-order SenseCam images, or by the title and random-order SenseCam images. In the control condition, older and younger adults’ memories were comparably episodic, but older adults recalled more semantic details. Both forward- and random-order SenseCam images were associated with increased episodic and semantic recall in both groups, and there was a small but significant effect of temporal order favouring the forward-order condition. These findings suggest that SenseCam is effective in supporting retrieval of memory for recent events, and the results of the temporal order manipulation also shed light on the mechanism of SenseCam’s effect