Effects of mistuning on dynamic behavior of nonlinear cyclic systems with lump masses and cubic nonlinearity

Mistuning in cyclic symmetric systems increases severely the forced response of system and splits the modes. This paper concerns with nonlinear behavior of mistuned cyclic systems. A nonlinear, mistuned model based on the method of multiple scales is proposed and formulated in which nonlinearity and mistuning parameter is assumed to be in of low order. Next, two mistuned systems were considered and solved by the multiple scale technique. Numerical results demonstrate that mistuning can lead to repeating and scattering of jump phenomena during the excitation frequency whereas in tuned cyclic system it occurs simultaneously (synchronously).Peer ReviewedPostprint (published version

An experimental determination of perceived liveability in Sydney

Liveability is a concept and factor being used by urban planners and designers to better understand how people perceive the places they live and work in and how it affects their life choices. Existing normative liveability indices are based on measurable and reproducible factors. They aim to objectively compare various residential conditions and their evolution. However, better understanding decisional processes attached to transport or residential choices necessitates a more dynamic approach. The concept of perceived liveability addresses the subjective nature of individual assessments of local environmental conditions. First, we have developed an empirical model based on subjective ranking and evaluation of six environmental factors. Then, we have conducted a pilot Computer Assisted Telephone Interviewing (CATI) survey in Sydney to inform our empirical model. Finally, a linear additive model was fitted to the survey data in order to represent various levels of satisfaction based on residential and socio-demographic conditions. (Résumé d'auteur

A new operational matrix based on Bernoulli polynomials

In this research, the Bernoulli polynomials are introduced. The properties of these polynomials are employed to construct the operational matrices of integration together with the derivative and product. These properties are then utilized to transform the differential equation to a matrix equation which corresponds to a system of algebraic equations with unknown Bernoulli coefficients. This method can be used for many problems such as differential equations, integral equations and so on. Numerical examples show the method is computationally simple and also illustrate the efficiency and accuracy of the method

Application of extreme environmental conditions to resuscitation of viable but non culturable E. coli DH5α

The resuscitation of Viable But Non-Culturable (VBNC) state in Escherichia coli DH5α as one of the most usable expression host was investigated. The VBNC state in bacteria is defined as while the cells are alive but unable to grow visibly on nonselective growth medium. After collecting several samples, Non-culturable E. coli DH5α (that has undertaken on various recombinant manipulations) were divided into different groups in order to carry-out different experiments. They were treated to heat shock at 42ºC in different periods of time, different concentration of Bile-salts and NaCl and combinational of these methods. The results showed that the almost of resuscitation treatment had positive effect on reactivation of VBNC E. coli DH5α. The combination of these parameters (various NaCl and bile salts concentration and heat shock method at 42 °C in different time) in a binary manner, also inferred to suitable results. Furthermore, by applying the three stresses simultaneously we achieved optical density up to 0.58 and 9×108 CFU/ml which had presented the best results. The results show that by applying some alterations in the condition of such recombinant E. coli DH5α, the growth path of these bacteria which remain to a VBNC phase can be changed to the normal status

Local P-shtukas and their relation to global G-shtukas

This is the first in a sequence of two articles investigating moduli stacks of global G-shtukas, which are function field analogs for Shimura varieties. Here G is a flat affine group scheme of finite type over a smooth projective curve, and global G-shtukas are generalizations of Drinfeld shtukas and analogs of abelian varieties with additional structure. Our moduli stacks generalize various moduli spaces used by different authors to prove instances of the Langlands program over function fields. In the present article we explain the relation between global G-shtukas and local P-shtukas, which are the function field analogs of p-divisible groups with additional structure. We prove the analog of a theorem of Serre and Tate stating the equivalence between the deformations of a global G-shtuka and its associated local P-shtukas. We also investigate local P-shtukas alone and explain their relation with Galois representations through their Tate modules. And if P is a smooth affine group scheme with connected reductive generic fiber we prove the existence of Rapoport--Zink spaces for bounded local P-shtukas as formal schemes locally formally of finite type. In the sequel to this article we use these Rapoport--Zink spaces to uniformize the moduli stacks of global G-shtukas.Comment: 37 pages, v3: generalization to flat affine group schemes of finite type, v3: final version which appears in Muenster J. of Mathematic

Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells

MicroRNAs (miRNA) are a large family of small single-stranded RNA molecules found in all multicellular organisms. Early studies have been shown that miRNA are involved in cancer development and progression, and this role can be done by working as an oncogenes and tumor suppressor genes, so manipulation of this molecules can be a promising approach in cancer therapy, and experimental results represented that the modification in breast cancer phenotype is possible by miRNA expression alteration. miR-16, which is located in 13q14 chromosome, plays critical roles as a tumor suppressor by targeting several oncogenes which regulate cell cycle and apoptosis. Hence, in the present study, we investigated whether miR-16 could decline growth and survival of MCF-7 cell line as model of human breast cancer. MCF-7 cell line was infected with lentiviruses containing miR-16 precursor sequence. The effects of ectopic expression of miR-16 on breast cancer phenotype were examined by cell cycle analysis and apoptosis assays. miR-16 cytotoxicity effect was measured by the MTT assay. We showed that the miR-16 overexpression reduces Cyclin D1 and BCL2 at messenger RNA (mRNA) and protein levels in MCF-7 cell line. In addition, this is found that enforced expression of miR-16 decreases cell growth and proliferation and induces apoptosis in MCF-7 cells. In conclusion, our results revealed that upregulation of miR-16 would be a potential approach for breast cancer therapy. © 2015, The Society for In Vitro Biology