Essays in Public Finance and Environmental Economics

This dissertation focuses on topics concerning public finance, state capacity, and the environment. In the first chapter, we study the role of proximity to administrative power in explaining spatial inequality in access to public goods. Using a natural experiment in India that quadrupled the number of sub-districts (the lowest level of administrative jurisdiction), we explore the impact of redistribution of political power on spatial inequality of public good investment. By analyzing digitized high-resolution data encompassing approximately 10,000 villages spanning over 55 years, we demonstrate that reducing the distance to local government headquarters helps in bridging the gap in the provision of essential public amenities for remote villages, and furthermore, yields evidence of long-term improvements in state capacity. In the second chapter, we focus on turning points in tax collection. Our method detects both sustained accelerations and decelerations of tax collection (relative to GDP) in a global and historical sample of 150 countries since 1965. Turning points are prevalent (238 events in total), persistent for at least 15 years in many cases, and occur more frequently at lower levels of the country's development. We show that changes in the political environment are strong statistical predictors of accelerations, tax reforms, and economic changes less so. Decelerations appear more unpredictable than accelerations. In the third chapter, we study the ecological gains of place-based environmental measures to ramp up conservation efforts. By combining geo-referenced Indian village maps overlaid with digitized protected area maps and a fuzzy regression discontinuity design, we find that protected areas help improve forest cover. Villages located within protected areas also experienced improved economic activity, attributed in part to the growth of the tourism sector, particularly in wildlife sanctuaries. Moreover, our findings suggest that states which allocate a higher share of expenditure to the forestry sector exhibit stronger forest conservation outcomes

VANET: Analysis of Black hole Attack using CBR/UDP Traffic Pattern with Hash Function and GPSR Routing Protocol

With momentum of time huge development occurred in the field of MANET and VANET. As we know when new technology emerges it came with many advanages but definitely some limitation must be there. In WSN security is one of biggest challenges which we need to tackle to implement adhoc network. Main reason behind this is dynamic topology of sensing node because nodes are dynamic in nature rather than static. As technology came into existence side by side unethical activity also take place which try to access the data illegally to gain personnel profit. There are so many types of attack possibilities are there in adhoc network. Attack can be classified into active and passive. In our research article oue main concern is on black hole attack. According to this attack a malicious node with high priority number is deployed in between other nodes. Now this malicious node access the data and sends acknowledgement to source that data received. Source node will think that acknowledgement is sent by destination node but actually it is sent by malicious node.  In this research article performance analysis of the black hole attack in Vehicular Ad Hoc Network is executed

Opposition to Renewable Energy Facilities in the United States

More than 100 ordinances have been adopted in 31 states blocking or restricting new wind, solar, and other renewable energy facilities, and more than 160 of these projects have been contested in 48 states. Columbia Law School’s Sabin Center for Climate Change Law issued a report documenting these instances of local opposition to renewables

DBO: Response Time Fairness for Cloud-Hosted Financial Exchanges

In this paper, we consider the problem of hosting financial exchanges in the cloud. Financial exchanges require predictable, equal latency to all market participants to ensure fairness for various tasks, such as high speed trading. However, it is extremely difficult to ensure equal latency to all market participants in existing cloud deployments, because of various reasons, such as congestion, and unequal network paths. In this paper, we address the unfairness that stems from lack of determinism in cloud networks. We argue that predictable or bounded latency is not necessary to achieve fairness. Inspired by the use of logical clocks in distributed systems, we present Delivery Based Ordering (DBO), a new approach that ensures fairness by instead correcting for differences in latency to the participants. We evaluate DBO both in our hardware test bed and in a public cloud deployment and demonstrate that it is feasible to achieve guaranteed fairness and sub-100 microsecond latency while operating at high transaction rates

Quantitative tissue proteome profile reveals neutrophil degranulation and remodeling of extracellular matrix proteins in early stage gallbladder cancer

Gallbladder cancer (GBC) is an aggressive malignancy of the gastrointestinal tract with a poor prognosis. It is important to understand the molecular processes associated with the pathogenesis of early stage GBC and identify proteins useful for diagnostic and therapeutic strategies. Here, we have carried out an iTRAQ-based quantitative proteomic analysis of tumor tissues from early stage GBC cases (stage I, n=7 and stage II, n=5) and non-tumor controls (n=6) from gallstone disease (GSD). We identified 357 differentially expressed proteins (DEPs) based on ≥ 2 unique peptides and ≥ 2 fold change with p value < 0.05. Pathway analysis using the STRING database showed, ‘neutrophil degranulation’ to be the major upregulated pathway that includes proteins such as MPO, PRTN3, S100A8, MMP9, DEFA1, AZU, and ‘ECM organization’ to be the major downregulated pathway that includes proteins such as COL14A1, COL1A2, COL6A1, COL6A2, COL6A3, BGN, DCN. Western blot and/or IHC analysis confirmed the elevated expression of MPO, PRTN3 and S100A8 in early stage of the disease. Based on the above results, we hypothesize that there is an increased neutrophil infiltration in tumor tissue and neutrophil degranulation leading to degradation of extracellular matrix (ECM) proteins promoting cancer cell invasion in the early stage GBC. Some of the proteins (MPO, MMP9, DEFA1) associated with ‘neutrophil degranulation’ showed the presence of ‘signal sequence’ suggesting their potential as circulatory markers for early detection of GBC. Overall, the study presents a protein dataset associated with early stage GBC

Pharmacokinetic aspects of retinal drug delivery

Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to administer drugs to the retina, but this approach is applicable only in selected cases (e.g. anti-VEGF antibodies and soluble receptors). There are two basic approaches that can be adopted to improve retinal drug delivery: prolonged and/or retina targeted delivery of intravitreal drugs and use of other routes of drug administration, such as periocular, suprachoroidal, sub-retinal, systemic, or topical. Properties of the administration route, drug and delivery system determine the efficacy and safety of these approaches. Pharmacokinetic and pharmacodynamic factors determine the required dosing rates and doses that are needed for drug action. In addition, tolerability factors limit the use of many materials in ocular drug delivery. This review article provides a critical discussion of retinal drug delivery, particularly from the pharmacokinetic point of view. This article does not include an extensive review of drug delivery technologies, because they have already been reviewed several times recently. Instead, we aim to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment. This review is based on the literature and unpublished data from the authors' laboratory.Peer reviewe

Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study

Purpose: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst they were awaiting surgery due to reprioritisation of resources. Methods: This multicentre, multinational cohort study recruited 6045 patients from the UK, Spain and Portugal during the peak pandemic period (Feb–July 2020). Patients on BrET were followed up to investigate the duration of, and response to, BrET. This included changes in tumour size to reflect downstaging potential, and changes in cellular proliferation (Ki67), as a marker of prognosis. Results: 1094 patients were prescribed BrET, over a median period of 53 days (IQR 32–81 days). The majority of patients (95.6%) had strong ER expression (Allred score 7–8/8). Very few patients required expedited surgery, due to lack of response (1.2%) or due to lack of tolerance/compliance (0.8%). There were small reductions in median tumour size after 3 months’ treatment duration; median of 4 mm [IQR − 20, 4]. In a small subset of patients ( n = 47), a drop in cellular proliferation (Ki67) occurred in 26 patients (55%), from high (Ki67 ≥ 10%) to low (< 10%), with at least one month’s duration of BrET. Discussion: This study describes real-world usage of pre-operative endocrine therapy as necessitated by the pandemic. BrET was found to be tolerable and safe. The data support short-term (≤ 3 months) usage of pre-operative endocrine therapy. Longer-term use should be investigated in future trials