ЦИФРОВА ТРАНФОРМАЦІЯ БІЗНЕС-ПРОЦЕСІВ ЯК ОСНОВНА СКЛАДОВА ФОРМУВАННЯ СТРАТЕГІЇ РОЗВИТКУ ПІДПРИЄМСТВ

У статті досліджується вплив інформаційних та цифрових технологій на розвиток бізнес-процесів підприємств в умовах переходу до цифрової економіки. Автори аналізують теоретичні та методологічні підходи до формування стратегій діяльності підприємств, які спрямовані на підвищення конкурентоспроможності, ефективності та інноваційного потенціалу. Розглянуто особливості впровадження інформаційних технологій, які сприяють оптимізації управлінських процесів і поширенню прогресивного управлінського досвіду. Особлива увага приділяється ролі державних органів у підтримці цифровізації, що виявляється у впровадженні національних стратегій цифрової трансформації. Окреслено ключові напрямки автоматизації та технічного переоснащення підприємств, які необхідні для їх стійкого розвитку в сучасних умовах. Стаття також підкреслює важливість інвестицій у науково-дослідницькі проекти, розвиток інноваційних рішень та участь у цифрових екосистемах для забезпечення стійкого розвитку підприємств

The effect of salt-free - salt diet on the reproductive performance of Ile de France ewes

The aim of the present study was to establish the effect of salt-free - salt diet (SFSD) on the size of antral follicles during salt consumption, the duration of controlled breeding campaign and the ferti¬lities of ewes from the Ile de France breed. Тhe experiment was carried out with 57 ewes, which were divided into 3 groups (19 ewes in each) depending on whether they were subjected to SFSD and their contacts with rams during the first 8 days of the beginning of breeding: Group I – SFSD + ram con-tact; Group II – only SFSD; Group III – no SFSD, only ram contacts. The first day of the salt diet coincided with the first day of ram contacts. Transrectal ultrasound examinations of the ovaries were done on days 1, 2, 3, 5, 6 and 7. The time of manifestation of estrus (in days), pregnancy rate and fecundity were studied. A significant effect of time (P<0.05) and diet (P<0.01) on the size of follicles was established. The onset of the first estrus, the shortest terms of breeding campaign, the fertility and the fecundity results gave us reason to favour the scheme applied to Group II. A stimulatory effect of the diet in that study was demonstrated, but the pattern was different from our previous studies

Economic consequences of financial stability violation of world automotive corporations

Global changes in the economic situation encourage modern corporations to find ways to increase their financial stability. It becomes possible by studying the state of their operational and financial activities, identifying problems and exploring opportunities that can optimize the financial position. The activity of automotive corporations has a significant impact on the stability of the global economic situation, the financial stability violation of which may lead to negative fluctuations in the world’s securities trading centres, and may lead to acrisis situation in the automotive market. That is why thestudy of the economic consequences of financial stabilityviolation of the world automotive corporations is animportant and current topic of the present. The purpose of the research is to determine the stateof automotive corporations’ financial stability and to generalize the consequences of its violation for theiractivity and the global economy as a whole.The purpose of the paper is to determine the state of automotive corporations’ financial stability and to generalize the consequences of its violation for their activity and the global economy as a whole. Methods. The theoretical and methodological basis of the research is the scientific works in the field of corporate finance management and strategic development that studied analysing and evaluating the financial stability of corporate companies, maintaining their financial stability in the medium and long term, official statistics data of United Nations Conference on Trade and Development, financial statements of corporations Toyota Motor Corporation (Japan), Mercedes-Benz (Germany), and Tesla Motors (USA), own research results. The methodological basis of the study is a set of general scientific and special methods used to achieve the research goal: theoretical generalization, analysis and synthesis – in studying the content of scientific works on the research of financial stability of corporate companies and maintaining their financial stability; observation – to obtain primary information about the state of the world automotive market; the method of coefficient analysis and typing the situations – to assess the financial stability of automotive corporations; analytical – in determining the economic consequences of financial stability violation of automotive corporations; causation  – to obtain final conclusions. Results. This article deals with the development of automotive industry in the world. The financial stability of leading automotive corporations is evaluated. The economic consequences of financial stability violation of automotive corporations are summarized. Financial strategies to improve the financial stability of automotive corporations are proposed. Practical value. The results of the study may be useful to the United Nations Conference on Trade and Development, the financial management of Toyota Motor Corporation, Mercedes-Benz and Tesla Motors. Value/originality – the state of financial stability of automotive corporations is determined and the consequences of its violation for their activity and the world economy as a whole are generalized. Further research should be directed towards the development of project measures to improve the financial stability of automotive corporations in the world

Sulfide trace element signatures and S- and Pb-isotope geochemistry of porphyry copper and epithermal gold-base metal mineralization in the Elatsite–Chelopech ore field (Bulgaria)

The Elatsite–Chelopech ore field in the northern part of the Panagyurishte district in Central Bulgaria comprises numerous spatially associated porphyry copper and epithermal gold deposits and prospects. In addition to the mineralization and alteration features, trace elements, lead and sulfur isotope signatures of sulfide minerals from porphyry copper, base metal and gold-base metal deposits/prospects have been studied. LA-ICP-MS analyses of pyrite, arsenopyrite and sulfosalt minerals validate them as major carriers for Au, Ag, Sb, Se and Co. Pyrite from the three types of mineralization has specific geochemical characteristics. Pyrite from the porphyry copper deposits/prospects has generally lower total trace element content compared to pyrite from the epithermal prospects, except for Se, Co and Ni. Pyrite from the base metal and gold-base metal veins is enriched in As, Au, Ag, Sb and Pb. In pyrite from the base metal deposits, Co and Ni have contents comparable to the pyrite from the porphyry copper deposits, while pyrite from the gold-base metal veins shows lower Co and Ni. Arsenopyrite from these deposits shows similar features. Similarly, sphalerite from the gold-base metal veins also has lower Co content compared to sphalerite from the base metal veins but higher In and Cu contents. In addition to the close spatial relationships between the Elatsite and Gorna Kamenitsa porphyry Cu deposits and Negarstitsa-West and Dolna Kamenitsa base metal prospects, as well as similarities in the mineralization and alteration styles, the lead isotopic (206Pb/204Pb = 18.61–18.68, 207Pb/204Pb = 15.64–15.65 for porphyry and 206Pb/204Pb = 18.55–18.67, 207Pb/204Pb = 15.64–15.68 for base metal) and sulfur isotopic (δ34S values of −3 to +1‰ for porphyry and δ34S values of −1.7 to +3.5‰ for base metal) signatures of sulfides support the idea of a genetic link between these two types of deposits. The porphyry and base-metal mineralization result from a common major ore-forming event during the Late Cretaceous, corresponding to deep/higher-temperature and shallower/distal/lower-temperature environments, respectively. In particular, more radiogenic lead (206Pb/204Pb = 18.41–18.47, 207Pb/204Pb = 15.67–15.76) and slightly different sulfur isotopic compositions (δ34S values of +3.5 to +10.6‰) of sulfides from the distal gold-base metal veins of Kordunsko Dere, Svishti Plaz and Shipkite might be a consequence of the interaction of the ore-forming fluids with an external older crustal and isotopically positive S source. Alternatively, a different fluid source/event for the formation of these gold-base metal veins may be suggested

Dysgerminoma in three patients with Swyer syndrome

<p>Abstract</p> <p>Background</p> <p>Dysgerminoma is the most common malignant germ cell tumor of the ovary. This malignancy can be associated with pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis and partial gonadal dysgenesis.</p> <p>Case presentation</p> <p>Dysgerminoma developed in 3 phenotypic female patients with 46 XY pure gonadal dysgenesis. All patients presented first with abdominopelvic mass. Laparatomy was done. 46 XY karyotype was made by lymphocyte culture. Then these patients underwent gonadectomy that histopathology results were streak ovaries without evidence for malignancy. Two patients received postoperative adjuvant therapy.</p> <p>Conclusion</p> <p>In Patients with Swyer syndrome the risk of dysgerminoma is high and gonadectomy is recommended. Also 5% of dysgerminomas are discovered in phenotypic female and 46 XY karyotype, thus in adolescent with dysgerminoimas and amenorrhea, karyotype should be done.</p

Coexistence of copy number increases of c-Myc, ZNF217, CCND1, ErbB1 and ErbB2 in ovarian cancers

Background: We selected 5 oncogenes with well-established roles in carcinogenesis – CCND1, ErbB1, ErbB2, c-mycand ZNF217– to investigate the coexistence of their copy imbalances in relation to the clinico-pathological characteristics of ovarian tumors. Materials and Methods: Fluorescence in situ hybridization for the 5 genes was applied to a preexisting tissue microarray. 38 ovarian tumors were successfully analyzed for copy number changes of the 5 genes. Results: At least one of these oncogenes was gained/amplified in 27 out of 38 tumors (71.1). We report the highest frequency of c-mycgenetic gain/amplification since it affected 42.1 of the ovarian tumors. We observed sequential involvement of copy number alterations of the other genes in the presence of c-mycdisruption. The incidence of copy number changes of the 5 oncogenes – both single and combinatorial – was higher in high-grade tumors. All double aberrations in the serous group comprised c-mycand ZNF217copy number increases. Conclusions: Our results revealed a combination between copy number increases of c-mycand ZNF217, associated with serous histology. The data from this combined analysis of the 5 oncogenes could be used as a basis in considering the combined approach in molecular-based therapy of ovarian cancer

Investigation of spin-orbit interaction in AlGaN/GaN heterostructures with large electron density

Magnetotransport phenomena in the high-density two-dimensional electron gas of AlGaN/GaN heterostrutures are investigated. Peculiarities of low- and high-field magnetotransport measurements in the temperature range from 0.3 to 10 K are discussed. The weak localization and antilocalization effects are observed and analyzed. The Rashba constant describing the spin-orbit interaction is extracted from the results of low-field magnetotransport for the structure with 33% aluminum content in the barrier and an electron sheet density of 1.1 x 10(13) cm(-2) and appears to be of 1.01 x 10(-10) eV cm