A Shortened Synthesis of Optically Pure Tricarbonyl[methyl (2E,4E)-6-oxo-2,4-hexadienoate]Iron Leading to Improved Yield

The (+)- and (–)-enantiomers of tricarbonyl[methyl (2E,4E)-6-oxo-2,4-hexadienoate]iron are prepared in 4 steps from commercially available hexadienal (26% and 25% yields, respectively)

Reactivity of acyclic (pentadienyl)iron(1+) cations: Synthetic studies directed toward the frondosins

A short, 4-step route to the scaffold of frondosin A and B is reported. The [1-methoxycarbonyl-5-(2′,5′-dimethoxyphenyl)pentadienyl]Fe(CO)3+ cation was prepared in two steps from (methyl 6-oxo-2,4-hexadienoate)Fe(CO)3. Reaction of this cation with isopropenyl Grignard or cyclohexenyllithium reagents affords (2-alkenyl-5-aryl-1-methoxycarbonyl-3-pentene-1,5-diyl)Fe(CO)3 along with other addition products. Oxidative decomplexation of these (pentenediyl)iron complexes, utilizing CuCl2, affords 6-aryl-3-methoxycarbonyl-1,4-cycloheptadienes via the presumed intermediacy of a cis-divinylcyclopropane

Role of Metal Nanoparticles on porosification of silicon by metal induced etching (MIE)

Porosification of silicon (Si) by metal induced etching (MIE) process have been studies here to understand the etching mechanism. The etching mechanism has been discussed on the basis of electron transfer from Si to metal ion (Ag$^+$) and metal to H$_2$O$_2$. Role of silver nanoparticles (AgNPs) in the etching process has been investigated by studying the effect of AgNPs coverage on surface porosity. A quantitative analysis of SEM images, done using Image J, shows a direct correlation between AgNPs coverage and surface porosity after the porosification. Density of Si nanowires (NWs) also varies as a function of AgNPs fractional coverage which reasserts the fact that AgNPs governs the porosification process during MIE.Comment: 8 pages, 5 figure

Studies on genetic variability for some metric traits in slender grain rice genotypes

An experiment was conducted to study genetic variability in forty-nine elite slender grain rice genotypes for thirteen component characters including grain yield.The experimental materials possessed a considerable amount of variability for all the traits. Majority of the traits showed the smaller difference between phenotypic coefficient of variation (PCV) and genotypic coefficient of variation (GCV). Both PCV and GCV were high for grain yield (gm) (PCV:27.14%, GCV:26.27%), and fertile grains per panicles(PCV:20.61%, GCV:20.52%), indicating less effect of environment on these characters. PCV and GCV were moderate for characters like harvest index (PCV:16.99%, GCV: 14.18%), 100 seed weight (gm) (PCV:14.57%, GCV:13.82%), fertility percentage (PCV:15.72%, GCV:15.05%), flag leaf area (cm2 ) (PCV:17.83%, GCV: 17.74%) and days to 50 % flowering (PCV:11.20%, GCV:11.17%) indicating that there is considerable amount of environmental effect on such characters. Moderate to a high degree of heritability estimates were observed for the majority of the traits under study except for a number of effective tillers/plant indicating the low or negligible influence of environment in the expression of these traits and may respond to selection for their improvement. High heritability (H2 )estimates were associated with moderate to high genetic gain over mean (GAM) for days to 50% flowering (H2 : 99.35%,GAM: 19.52%), plant height (H2 :93.89%,GAM:14.01%), panicle length (H2 :94.06%,GAM:14.04%), flag leaf area(H2 : 98.93%,GAM: 31.05%), fertile grains/panicle (H2 :99.20%,GAM: 35.98%), fertility percentage (H2 :91.57%,GAM:25.34%),100 seed weight (H2 :89.90%,GAM:23.06%)and grain yield per plant (H2 :93.71%,GAM:44.76%) indicating the presence of additive gene effect and hence selection based on phenotypic performance for these traits would be effective

Probing the Human Estrogen Receptor-α Binding Requirements for Phenolic Mono- and Di-Hydroxyl Compounds: A Combined Synthesis, Binding and Docking Study

Various estrogen analogs were synthesized and tested for binding to human ERα using a fluorescence polarization displacement assay. Binding affinity and orientation were also predicted using docking calculations. Docking was able to accurately predict relative binding affinity and orientation for estradiol, but only if a tightly bound water molecule bridging Arg394/Glu353 is present. Di-hydroxyl compounds sometimes bind in two orientations, which are flipped in terms of relative positioning of their hydroxyl groups. Di-hydroxyl compounds were predicted to bind with their aliphatic hydroxyl group interacting with His524 in ERα. One nonsteroid-based dihdroxyl compound was 1000-fold specific for ERβ over ERα, and was also 25-fold specific for agonist ERβ versus antagonist activity. Docking predictions suggest this specificity may be due to interaction of the aliphatic hydroxyl with His475 in the agonist form of ERβ, versus with Thr299 in the antagonist form. But, the presence of this aliphatic hydroxyl is not required in all compounds, since mono-hydroxyl (phenolic) compounds bind ERα with high affinity, via hydroxyl hydrogen bonding interactions with the ERα Arg394/Glu353/water triad, and van der Waals interactions with the rest of the molecule

Suspension Assembly of BAJA ATV

In the modern day and age where automobiles are an essential part of our day to day life, the requirements of each are different. Some demand for a high-performance machine whereas others require a comfortable ride. The modern engineering helps in achieving all the aspects of a safe, reliable and fast vehicle. With the change in time, the need for an all-terrain vehicle has gradually increased. The research paper includes the optimisation of wheel assembly for better stability, comfort ride along with better handling. The analysis and simulation are done to obtain a better wheel assembly which can provide the best in class arrangements for the customer. The research mainly focused on the wheel hub, wishbones and knuckle. The designs provide the sturdiness and durability which is the primary requirement for an all-terrain vehicle. The key focus is given to material selection which provides durability and comfort. The material is inexpensive which presents an edge for the market competition as well as is value for money for the customer point of view. The Static load on wheel hub is calculated and analysed for elucidating the characteristics. The material EN-24 provides better machinability and welding applications making it more suitable for mass production

A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions

Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings. The most potent and selective A–C estrogen is selective for activating ER relative to seven other nuclear hormone receptors, with a surprising 750-fold selectivity for the β over α isoform and with EC50s of 20–30 nM in cell-based and direct binding assays. Comparison of potency in different assays suggests that the ER isoform selectivity is related to the compound’s ability to drive the productive conformational change needed to activate transcription. The compound also shows in vivo efficacy after microinfusion into the dorsal hippocampus and after intraperitoneal injection (0.5 mg/kg) or oral gavage (0.5 mg/kg). This simple yet novel A–C estrogen is selective, brain penetrant, and facilitates memory consolidation

Revamping Legacy- The Sustainable Transformation A Case Study of Anchal Leather Company Limited (ALCL)

The leather industry plays a crucial role in the global economy, contributing significantly to employment and exports. With major production hubs in key markets such as China, India, Italy, and Brazil, the industry continues to evolve to meet shifting consumer demands and environmental challenges. Anchal Leather Company Limited (ALCL) has established itself as a prominent player in this dynamic sector, known for its commitment to premium quality, innovative designs, and sustainable practices. By blending traditional craftsmanship with modern advancements, ALCL has expanded its product range to cater to diverse industries, including fashion, automotive, and luxury accessories. The company's dedication to excellence, coupled with its focus on eco-friendly solutions, positions ALCL as a forward-thinking leader in the evolving leather market. As consumer preferences increasingly prioritize ethical and high-quality leather goods, ALCL remains committed to delivering innovative products that align with modern sustainability trends