New York Harbor Observing and Prediction System (NYHOPS)

Abstrac

Renal function, sodium and water homeostasis in patients with idiopathic extrahepatic portal vein thrombosis compared with normal healthy controls

Objectives. To determine whether portal hypertension in the absence of liver disease contributes to changes in renal function and renal sodium and water handling.Methods. Nine patients with extrahepatic portal vein thrombosis (PVT) with normal liver function and histology were compared with 9 matched healthy control subjects. All underwent standard measurements of glomerular filtration rate and effective renal blood flow using inulin and paraaminohippuric acid (PAH) clearances, respectively. Sodium excretion and renin and aldosterone levels were studied before, during and after an intravenous saline infusion,Results. At baseline there were no differences in inulin clearance, PAH clearance, fractional excretion of sodium and free water excretion. During and after the saline infusion both groups showed a significant increase in sodium excretion with a reduction in water excretion, while the PAH and inulin clearances remained unchanged. Although aldosterone and renin levels both fell after the infusion, aldosterone levels were significantly lower in the PVT group. There were no other significant differences between the PVT and control groups.Conclusion. Renal function and sodium and water handling were comparable in healthy controls and patients with PVT. It is unlikely that portal hypertension alone plays a significant role in the impaired ability to excrete sodium and water in patients with liver cirrhosi

Ocean observing and the blue economy

Sustained ocean observations provide an essential input to ocean scientific research. They also support a wide range of societal and economic benefits related to safety; operational efficiency; and regulation of activities around, on, in, and under seas and the ocean. The ocean economy is large and diverse, accounting for around US$1.5 trillion of global gross value-added economic activity. This is projected to more than double by 2030. Delivering this growth in economic activity is dependent on ocean observations. This review paper summarizes the projected changes in the scale and scope of the ocean economy and the role that observations, measurements, and forecasts play in supporting the safe and effective use of the ocean and ocean resources, at the same time as protecting the environment. It also provides an overview of key future work being planned to develop a better understanding of the present and likely future ocean economy and the role and value of ocean observations in its sustainable realization

The Ocean Enterprise–understanding and quantifying business activity in support of observing, measuring and forecasting the ocean

Sustained ocean observations, measurements and models provide a wide range of societal benefits underpinning the safety, operational and compliance needs of beneficiaries that operate around, on and under the ocean (In the context of this paper, the term ‘ocean’ is defined as encompassing the global ocean, enclosed seas and the US Great Lakes.) They also provide an essential input to ocean scientific research and the effective protection of the marine environment. Delivering the means to collect and use ocean data and information on a sustained basis constitutes a significant business undertaking. The companies that enable sustained ocean observation, measurement and forecasting, and deliver its benefits as commercial services, combine to create a unique and growing industry cluster; the Ocean Enterprise. Ocean Enterprise businesses underpin the ability to provide societal benefit from sustained ocean observations, measurements and models, as well as delivering significant economic and employment benefits in their own right. In this paper, we describe a systematic evaluation of the scale, scope and characteristics of the Ocean Enterprise in the United States. We explore the ways in which this industry cluster interacts with the US Integrated Ocean Observing System and how the United States Ocean Enterprise compares to that of the United Kingdom

Terminology Related to Ocean and Coastal Economic Activity

This communication paper considers the definition and usage of terms describing ocean and coastal economic activity and the provision of the ocean data, information and knowledge needed to support its evolution and development

A genome-wide association study of anorexia nervosa.

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field

Eating disorder symptomatology and body mass index are associated with readers’ expectations about character behavior: evidence from eye-tracking during reading

Objective: Many theories have been put forward suggesting key factors underlying the development and maintenance of eating disorders, such as: unhealthy food-related cognitive biases, negative body attitude, and perfectionism; however, underlying cognitive processes associated with eating disorder symptomatology remain unclear. We used eye-tracking during reading as a novel implicit measure of how these factors may relate to eating disorder symptomatology. Method: In two experiments, we monitored women’s eye movements while they read texts in which the characters’ emotional responses to food-, body image-, and perfectionism-related scenarios were described. Participants’ eating disorder symptomatology was then assessed. Results: Both studies suggest that moment-to-moment processing of characters’ emotional responses to perfectionism-, and to a lesser extent, body image-related information was associated with participants’ eating disorder symptomatology, thus supporting theories in which these factors are key to developing and maintaining eating disorders