Potential Roles of Adropin in Central Nervous System: Review of Current Literature

Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed

Force-based control for human-robot cooperative object manipulation

In Physical Human-Robot Interaction (PHRI), humans and robots share the workspace and physically interact and collaborate to perform a common task. However, robots do not have human levels of intelligence or the capacity to adapt in performing collaborative tasks. Moreover, the presence of humans in the vicinity of the robot requires ensuring their safety, both in terms of software and hardware. One of the aspects related to safety is the stability of the human-robot control system, which can be placed in jeopardy due to several factors such as internal time delays. Another aspect is the mutual understanding between humans and robots to prevent conflicts in performing a task. The kinesthetic transmission of the human intention is, in general, ambiguous when an object is involved, and the robot cannot distinguish the human intention to rotate from the intention to translate (the translation/rotation problem).This thesis examines the aforementioned issues related to PHRI. First, the instability arising due to a time delay is addressed. For this purpose, the time delay in the system is modeled with the exponential function, and the effect of system parameters on the stability of the interaction is examined analytically. The proposed method is compared with the state-of-the-art criteria used to study the stability of PHRI systems with similar setups and high human stiffness. Second, the unknown human grasp position is estimated by exploiting the interaction forces measured by a force/torque sensor at the robot end effector. To address cases where the human interaction torque is non-zero, the unknown parameter vector is augmented to include the human-applied torque. The proposed method is also compared via experimental studies with the conventional method, which assumes a contact point (i.e., that human torque is equal to zero). Finally, the translation/rotation problem in shared object manipulation is tackled by proposing and developing a new control scheme based on the identification of the ongoing task and the adaptation of the robot\u27s role, i.e., whether it is a passive follower or an active assistant. This scheme allows the human to transport the object independently in all degrees of freedom and also reduces human effort, which is an important factor in PHRI, especially for repetitive tasks. Simulation and experimental results clearly demonstrate that the force required to be applied by the human is significantly reduced once the task is identified

Force-based Perception and Control Strategies for Human-Robot Shared Object Manipulation

Physical Human-Robot Interaction (PHRI) is essential for the future integration of robots in human-centered environments. In these settings, robots are expected to share the same workspace, interact physically, and collaborate with humans to achieve a common task. One of the primary tasks that require human-robot collaboration is object manipulation. The main challenges that need to be addressed to achieve a seamless cooperative object manipulation are related to uncertainties in human trajectory, grasp position, and intention. The object’s motion trajectory intended by the human is not always defined for the robot and the human may grasp any part of the object depending on the desired trajectory. In addition, the state-of-the-art object-manipulation control schemes suffer from the translation/rotation problem, where the human cannot move the object in all degrees of freedom, independently, and thus, needs to exert extra effort to accomplish the task. To address the challenges, first, we propose an estimation method for identifying the human grasp position. We extend the conventional contact point estimation method by formulating a new identification model with the human applied torque as an unknown parameter and employing empirical conditions to estimate the human grasp position. The proposed method is compared with a conventional contact point estimation using the experimental data collected for various collaboration scenarios. Second, given the human grasp position, a control strategy is suggested to transport the object in all degrees of freedom, independently. We employ the concept of “the instantaneous center of zero velocity” to reduce the human effort by minimizing the exerted human force. The stability of the interaction is evaluated using a passivity-based analysis of the closed-loop system, including the object and the robotic manipulator. The performance of the proposed control scheme is validated through simulation of scenarios containing rotations and translations of the object. Our study indicates that the exerted torque of the human has a significant effect on the human grasp position estimation. Besides, the knowledge of the human grasp position can be used in the control scheme design to avoid the translation/rotation problem and reduce the human effort

Molecular Design Approach Managing Molecular Orbital Superposition for High Efficiency without Color Shift in Thermally Activated Delayed Fluorescent Organic Lightâ Emitting Diodes

Molecular design principles of thermally activated delayed fluorescent (TADF) emitters having a high quantum efficiency and a color tuning capability was investigated by synthesizing three TADF emitters with donors at different positions of a benzonitrile acceptor. The position rendering a large overlap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) enhances the quantum efficiency of the TADF emitter. Regarding the orbital overlap, donor attachments at 2â and 6â positions of the benzonitrile were more beneficial than 3â and 5â substitutions. Moreover, an additional attachment of a weak donor at the 4â position further increased the quantum efficiency without decreasing the emission energy. Therefore, the molecular design strategy of substituting strong donors at the positions allowing a large molecular orbital overlap and an extra weak donor is a good approach to achieve both high quantum efficiency and a slightly increased emission energy.Overlap to emit: The substitution of strong donors at the positions rendering a large HOMOâ LUMO overlap and the addition of a weak donor constitute an effective design approach to realize TADF emitters having high efficiency.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147817/1/chem201805616-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147817/2/chem201805616.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147817/3/chem201805616_am.pd

An overview of multi-ingredient kidney stone dissolving formulations from Traditional Persian Pharmacy

Kidney stone, as a third important urinary tract disease, is a common disease affecting 10-15% of the world population. Effective medical treatment for the disease is not yet well established. On the other hand, there is an increasing global demand to manage and control various diseases with natural medicine and medicaments originating from Complementary and Alternative Medicine (CAM). Traditional Persian medicine (TPM), as one of the most popular schools in CAM, suggests numerous clinical interventions for kidney stones. This review provides various related compound formulations for kidney/bladder stones from the standpoints of Persian scholars. These remedies have been cited in a series of traditional pharmaceutical manuscripts of Persian medicine, namely Qarābādin or prescription. More than fifty multi-ingredient formulations for kidney/bladder stones have been found by reviewing five main Persian pharmacopeias. Various dosage forms have been reported for the management of kidney/bladder stones, such as Majoon (confection), Sharāb (syrup), Jawārish (semisolid confection), Qors (Tablet), and Safoof (oral powder). Considering the positive pharmacological or biological activities of the constituents of filtered formulations, many of those can be re-formulated and either experimentally or clinically evaluated to be introduced as new natural remedies in this field

Efficacy of biological agents and fillers seed coating in improving drought stress in anise

Many plants, including anise, have tiny, non-uniform seeds with low and light nutrient reserves. The seeds also show a weak establishment, especially under stressful conditions where their accurate planting in the soil and optimal yield are tough. This study sought to improve anise seeds' physical and physiological characteristics under drought stress. To this end, two factorial experiments under laboratory and greenhouse conditions were performed in a completely randomized design with 4 and 3 replications, respectively. Five levels of seed inoculation (inoculation with T36 and T43 of Trichoderma harzianum, and CHA0 and B52 of Pseudomonas fluorescent, and non-inoculation which means that control seeds were not treated with microbial inoculant), three levels of coating (K10P20, K10P10V5, and non-coating), and three levels of drought stress (0, -3, and -6 bars) were considered as the factorial experiment [vermiculite (V), kaolin (K), and perlite (P) numbers refer to the amount of material used in grams]. The laboratory experiment revealed that the combined treatments of bio-agents with coating increased the physical and germination characteristics of anise seeds compared to the control treatment. The greenhouse experiment showed that drought stress reduced the initial growth indices. Still, the combination treatments of biological agents and coating (fillers) could alleviate the destructive effects of drought stress to some extent and improve these indices. The best treatment was provided by T36 and K10P20 in both experiments, which significantly increased morphological indices.Peer reviewe

Prevalence and predictors of low back pain among the Iranian population: Results from the Persian cohort study

Background and objectives: Low back pain (LBP) is a common health condition in populations. Limited large-scale population-based studies evaluated the prevalence and predictors of LBP in developing countries. This study aimed to evaluate the prevalence and factors associated with LBP among the Iranian population. Methods: We used baseline information from the Prospective Epidemiological Research Studies in Iran (PERSIAN), including individuals from 16 provinces of Iran. LBP was defined as the history of back pain interfering with daily activities for more than one week during an individual's lifetime. Various factors hypothesized to affect LBP, such as age, sex, marital status, educational status, ethnicity, living area, employment status, history of smoking, body mass index (BMI), physical activity, sleep duration, wealth score, history of joint pain, and history of morning stiffness in the joints were evaluated. Results: In total, 163770 Iranians with a mean age of 49.37 (SD = 9.15) were included in this study, 44.8% of whom were male. The prevalence of LBP was 25.2% among participants. After adjusting for confounders, the female gender [OR:1.244(1.02-1.50)], middle and older ages [OR:1.23(1.10-1.33) and OR:1.13(1.07-1.42), respectively], being overweight or obese [OR:1.13(1.07-1.19) and OR:1.21(1.16-1.27), respectively], former and current smokers (OR:1.25(1.16-1.36) and OR:1.28(1.17-1.39), respectively], low physical activity [OR:1.07 (1.01-1.14)], and short sleep duration [OR: 1.09(1.02-1.17)] were significantly associated with LBP. Conclusion: In this large-scale study, we found the lifetime prevalence of LBP to be lower among the Iranian population in comparison to the global prevalence of LBP; further studies are warranted to evaluate the causality of risk factors on LBP

Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants

Background: Diabetes can be detected at the primary health-care level, and effective treatments lower the risk of complications. There are insufficient data on the coverage of treatment for diabetes and how it has changed. We estimated trends from 1990 to 2022 in diabetes prevalence and treatment for 200 countries and territories. Methods: We used data from 1108 population-representative studies with 141 million participants aged 18 years and older with measurements of fasting glucose and glycated haemoglobin (HbA1c), and information on diabetes treatment. We defined diabetes as having a fasting plasma glucose (FPG) of 7·0 mmol/L or higher, having an HbA1c of 6·5% or higher, or taking medication for diabetes. We defined diabetes treatment as the proportion of people with diabetes who were taking medication for diabetes. We analysed the data in a Bayesian hierarchical meta-regression model to estimate diabetes prevalence and treatment. Findings: In 2022, an estimated 828 million (95% credible interval [CrI] 757–908) adults (those aged 18 years and older) had diabetes, an increase of 630 million (554–713) from 1990. From 1990 to 2022, the age-standardised prevalence of diabetes increased in 131 countries for women and in 155 countries for men with a posterior probability of more than 0·80. The largest increases were in low-income and middle-income countries in southeast Asia (eg, Malaysia), south Asia (eg, Pakistan), the Middle East and north Africa (eg, Egypt), and Latin America and the Caribbean (eg, Jamaica, Trinidad and Tobago, and Costa Rica). Age-standardised prevalence neither increased nor decreased with a posterior probability of more than 0·80 in some countries in western and central Europe, sub-Saharan Africa, east Asia and the Pacific, Canada, and some Pacific island nations where prevalence was already high in 1990; it decreased with a posterior probability of more than 0·80 in women in Japan, Spain, and France, and in men in Nauru. The lowest prevalence in the world in 2022 was in western Europe and east Africa for both sexes, and in Japan and Canada for women, and the highest prevalence in the world in 2022 was in countries in Polynesia and Micronesia, some countries in the Caribbean and the Middle East and north Africa, as well as Pakistan and Malaysia. In 2022, 445 million (95% CrI 401–496) adults aged 30 years or older with diabetes did not receive treatment (59% of adults aged 30 years or older with diabetes), 3·5 times the number in 1990. From 1990 to 2022, diabetes treatment coverage increased in 118 countries for women and 98 countries for men with a posterior probability of more than 0·80. The largest improvement in treatment coverage was in some countries from central and western Europe and Latin America (Mexico, Colombia, Chile, and Costa Rica), Canada, South Korea, Russia, Seychelles, and Jordan. There was no increase in treatment coverage in most countries in sub-Saharan Africa; the Caribbean; Pacific island nations; and south, southeast, and central Asia. In 2022, age-standardised treatment coverage was lowest in countries in sub-Saharan Africa and south Asia, and treatment coverage was less than 10% in some African countries. Treatment coverage was 55% or higher in South Korea, many high-income western countries, and some countries in central and eastern Europe (eg, Poland, Czechia, and Russia), Latin America (eg, Costa Rica, Chile, and Mexico), and the Middle East and north Africa (eg, Jordan, Qatar, and Kuwait). Interpretation: In most countries, especially in low-income and middle-income countries, diabetes treatment has not increased at all or has not increased sufficiently in comparison with the rise in prevalence. The burden of diabetes and untreated diabetes is increasingly borne by low-income and middle-income countries. The expansion of health insurance and primary health care should be accompanied with diabetes programmes that realign and resource health services to enhance the early detection and effective treatment of diabetes. Funding: UK Medical Research Council, UK Research and Innovation (Research England), and US Centers for Disease Control and Prevention