Series solutions for a static scalar potential in a Salam-Sezgin Supergravitational hybrid braneworld

The static potential for a massless scalar field shares the essential features of the scalar gravitational mode in a tensorial perturbation analysis about the background solution. Using the fluxbrane construction of [8] we calculate the lowest order of the static potential of a massless scalar field on a thin brane using series solutions to the scalar field's Klein Gordon equation and we find that it has the same form as Newton's Law of Gravity. We claim our method will in general provide a quick and useful check that one may use to see if their model will recover Newton's Law to lowest order on the brane.Comment: 5 pages, no figure

Rurality or distance to care and the risk of homelessness among Afghanistan and Iraq veterans

INTRODUCTION: To date, no studies have examined the relationship of rurality and distance to nearest VA facility to risk of homelessness. METHODS: We examined differences in the rate of homelessness within a year of a Veteran's first encounter with the VA following last military separation based on rurality and distance to the nearest VA facility using multivariable log-binomial regressions. RESULTS: In our cohort of 708,120 Veterans, 73% were determined to have a forwarding address in urban areas, 59.2% and 86.7% lived within 40 miles of the nearest VA medical center (VAMC), respectively. Veterans living in a rural area and those living between 20+ miles away from the nearest VAMC were at a lower risk for homelessness. CONCLUSIONS: Our unique dataset allowed us to explore the relationship between geography and homelessness. These results are important to policy makers in understanding the risk factors for homelessness among Veterans and planning interventions

Reflection symmetry breaking scenarios with minimal gauge form coupling in brane world cosmology

This article synthesises and extends recent work on the cosmological consequences of dropping the usual Z_2 reflection symmetry postulate in brane world scenarios. It is observed that for a cosmological model of homogeneous isotropic type, the relevant generalised Birkhoff theorem establishing staticity of the external vacuum in the maximally symmetric ``bulk'' outside a freely moving world brane will remain valid for the case of motion that is forced by minimal (generalised Wess Zumino type) coupling to an external antisymmetric gauge field provided its kinetic action contribution has the usual homogeneous quadratic form. This means that the geometry on each side of the brane worldsheet will still be of the generalised Schwarzschild anti de Sitter type. The usual first integrated Friedmann equation for the Hubble expansion rate can thereby be straightforwardly generalised by inclusion of new terms involving 2 extra parameters respectively measuring the strength of the gauge coupling and the degree of deviation from reflection symmetry. Some conceivable phenomenological implications are briefly outlined, and corresponding limitations are derived for possible values of relevant parameters.Comment: 13 pages latex (revised to rectify a couple of sign transcription errors

Closed System of Equations on a Brane

We obtain a generic closed system of equations on a brane that describes its inner evolution and give a method for extending solutions on the brane to the bulk. We also discuss the cosmological implications of the closed system of equations obtained. We consider bulk spaces with both spacelike and timelike extra dimension, with and without the $Z_2$ symmetry of reflection relative to the brane.Comment: 11 pages, revtex. Substantially revised version to be published in PL

Integrability of Some Charged Rotating Supergravity Black Hole Solutions in Four and Five Dimensions

We study the integrability of geodesic flow in the background of some recently discovered charged rotating solutions of supergravity in four and five dimensions. Specifically, we work with the gauged multicharge Taub-NUT-Kerr-(Anti) de Sitter metric in four dimensions, and the $U(1)^3$ gauged charged-Kerr-(Anti) de Sitter black hole solution of N = 2 supergravity in five dimensions. We explicitly construct the Killing tensors that permit separation of the Hamilton-Jacobi equation in these spacetimes. These results prove integrability for a large class of previously known supergravity solutions, including several BPS solitonic states. We also derive first-order equations of motion for particles in these backgrounds and examine some of their properties. Finally, we also examine the Klein-Gordon equation for a scalar field in these spacetimes and demonstrate separability.Comment: 17 Pages, updated bibliography, accepted for publication by Physics Letters

Separation Distribution of Vacuum Bubbles in de Sitter Space

We compute the probability distribution of the invariant separation between nucleation centers of colliding true vacuum bubbles arising from the decay of a false de Sitter space vacuum. We find that even in the limit of a very small nucleation rate per unit Hubble volume the production of widely separated bubble pairs is suppressed. This distribution is of particular relevance for the recently proposed ``colliding bubble braneworld'' scenario, in which the value of Omega_k (the contribution of negative spatial curvature to the cosmological density parameter) is determined by the invariant separation of the colliding bubble pair. We also consider the probability of a collision with a `third' bubble.Comment: 15 pages REVTEX, 2 Postscript figure

C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells.

CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized. We employed gene knockdown and rescue assays to explore the consequences of altered CEBPB gene expression in Ewing sarcoma cell lines. Knockdown of EWS-FLI1 expression led to a decrease in expression of all three C/EBPβ isoforms while re-expression of EWS-FLI1 rescued C/EBPβ expression. Overexpression of C/EBPβ-1, the largest of the three C/EBPβ isoforms, led to a significant increase in colony formation when cells were grown in soft agar compared to empty vector transduced cells. In addition, depletion of C/EBPβ decreased colony formation, and re-expression of either C/EBPβ-1 or C/EBPβ-2 rescued the phenotype. We identified the cancer stem cell marker ALDH1A1 as a target of C/EBPβ in Ewing sarcoma. Furthermore, increased expression of C/EBPβ led to resistance to chemotherapeutic agents. In summary, we have identified CEBPB as an oncogene in Ewing sarcoma. Overexpression of C/EBPβ-1 increases transformation, upregulates expression of the cancer stem cell marker ALDH1A1, and leads to chemoresistance

Geodetic Brane Gravity

Within the framework of geodetic brane gravity, the Universe is described as a 4-dimensional extended object evolving geodetically in a higher dimensional flat background. In this paper, by introducing a new pair of canonical fields {lambda, P_{lambda}}, we derive the quadratic Hamiltonian for such a brane Universe; the inclusion of matter then resembles minimal coupling. Second class constraints enter the game, invoking the Dirac bracket formalism. The algebra of the first class constraints is calculated, and the BRST generator of the brane Universe turns out to be rank-1. At the quantum level, the road is open for canonical and/or functional integral quantization. The main advantages of geodetic brane gravity are: (i) It introduces an intrinsic, geometrically originated, 'dark matter' component, (ii) It offers, owing to the Lorentzian bulk time coordinate, a novel solution to the 'problem of time', and (iii) It enables calculation of meaningful probabilities within quantum cosmology without any auxiliary scalar field. Intriguingly, the general relativity limit is associated with lambda being a vanishing (degenerate) eigenvalue.Comment: 23 pages, 1 figure, minor change

Breast vibro-acoustography: initial results show promise

INTRODUCTION: Vibro-acoustography (VA) is a recently developed imaging modality that is sensitive to the dynamic characteristics of tissue. It detects low-frequency harmonic vibrations in tissue that are induced by the radiation force of ultrasound. Here, we have investigated applications of VA for in vivo breast imaging. METHODS: A recently developed combined mammography-VA system for in vivo breast imaging was tested on female volunteers, aged 25 years or older, with suspected breast lesions on their clinical examination. After mammography, a set of VA scans was acquired by the experimental device. In a masked assessment, VA images were evaluated independently by 3 reviewers who identified mass lesions and calcifications. The diagnostic accuracy of this imaging method was determined by comparing the reviewers' responses with clinical data. RESULTS: We collected images from 57 participants: 7 were used for training and 48 for evaluation of diagnostic accuracy (images from 2 participants were excluded because of unexpected imaging artifacts). In total, 16 malignant and 32 benign lesions were examined. Specificity for diagnostic accuracy was 94% or higher for all 3 reviewers, but sensitivity varied (69% to 100%). All reviewers were able to detect 97% of masses, but sensitivity for detection of calcification was lower (≤ 72% for all reviewers). CONCLUSIONS: VA can be used to detect various breast abnormalities, including calcifications and benign and malignant masses, with relatively high specificity. VA technology may lead to a new clinical tool for breast imaging applications