Time and position distributions in large volume spherical scintillation detectors

Large spherical scintillation detectors are playing an increasingly important role in experimental neutrino physics studies. From the instrumental point of view the primary signal response of these set-ups is constituted by the time and amplitude of the anode pulses delivered by each individual phototube following a particle interaction in the scintillator. In this work, under some approximate assumptions, we derive a number of analytical formulas able to give a fairly accurate description of the most important timing features of these detectors, intended to complement the more complete Monte Carlo studies normally used for a full modelling approach. The paper is completed with a mathematical description of the event position distributions which can be inferred, through some inference algorithm, starting from the primary time measures of the photomultiplier tubes.Comment: 29 pages, 20 figures, accepted for publication on Nucl. Instr. and Meth.

On the significance in signal search through the sliding window algorithm

The experimental issue of the search for new particles of unknown mass poses the challenge of exploring a wide interval to look for the usual signatures represented by excess of events above the background. A side effect of such a broad range quest is that the traditional significance calculations valid for signals of known location are no more applicable when such an information is missing. In this note the specific signal search approach via observation windows sliding over the range of interest is considered; in the assumptions of known background and of fixed width of the exploring windows the statistical implications of such a search scheme are described, with special emphasis on the correct significance assessment for a claimed discovery.Comment: 10 pages, 6 figures, misprints corrected, an extended version will be published on NIM

Neutrino oscillations

In the last decades, a very important breakthrough has been brought in the elementary particle physics by the discovery of the phenomenon of the neutrino oscillations, which has shown neutrino properties beyond the Standard Model. But a full understanding of the various aspects of the neutrino oscillations is far to be achieved. In this paper the theoretical background of the neutrino oscillation phenomenon is described, referring in particular to the paradigmatic models. Then the various techniques and detectors which studied neutrinos from different sources are discussed, starting from the pioneering ones up to the detectors still in operation and to those in preparation. The physics results are finally presented adopting the same research path which has crossed this long saga. The problems not yet fixed in this field are discussed, together with the perspectives of their solutions in the near future

Towards Low-Threshold, Real-Time Solar Neutrino Detectors

We discuss an alternative approach to the detection of solar neutrinos using a coarsely segmented detector based on inverse-beta decay onto $^{160}$Gd or $^{176}$Yb. While it is know that similar approaches, already discussed in the literature, can in principle provide low-threshold, real-time energy spectroscopy with intrinsic background rejection features, the concepts presented here make this scheme possible with lower background and current technology.Comment: 10 pages, 2 figure

The single currency and European citizenship

We could expect that the introduction of the single currency had been accompanied by a significant share of studies and researches about the implications and impacts of such a watershed event on European citizenship. On the contrary, we soon discover to be facing a paradox, which could be phrased as follows: while the purpose of building European citizenship is the very rationale for the project of the single currency, the Scholars – but also the policy community – have mostly underestimated if not neglected this relation, both in terms of public policy making and discourse and of interpretation and forecasting. As a consequence of all of that, relevant features of the single currency happened to remain hidden, poorly considered and almost not thematized. In order to fill this gap, the first part of this article will present the main findings emerged from a documentary research conducted by FONDACA between 2010 and 2011, aimed at mapping the existing academic and policy thematizations about the hidden dimensions of the euro. The second part will be devoted to define “the other side of the coin” as an empirical phenomenon

Organization of aerobactin, hemolysin, and antibacterial resistance genes in lactose negative Escherichia coli strains of serotype O4 isolated from children with dhiarrea

Epidemiologically related, non-lactose-fermenting (NLF) Escherichia coli strains of serotype O4 have been isolated at a high frequency from children with diarrhea in Somalia (M. Nicoletti, F. Superti, C. Conti, A. Calconi, and C. Zagaglia, J. Clin. Microbiol. 26:524-529, 1988). In order to define the virulence potential of these strains, we characterized the replication properties of their high-molecular-weight plasmids and studied the genetic locations and organization of the aerobactin (aer) and hemolysin (hly) determinants encoded by 23 NLF O4 E. coli strains. Southern blot hybridizations, mobilization assays of nonconjugative plasmids, and incompatibility-exclusion experiments conducted with a conjugative incompatibility group FI (IncFI) plasmid showed that (i) 20 out of the 23 strains examined harbor a 160- to 180-kb IncFI plasmid that shares homology with the basic replicons RepFIA, RepFIB, and (except for the plasmid of one strain) RepFIC, and 22 strains also contain a 40- to 140-kb IncFII plasmid sharing homology with the RepFIIA replicon; (ii) the IncFI plasmid is nonconjugative and carries antibiotic resistance genes; (iii) the aer system is located on the IncFI plasmids and/or the chromosomes in the three strains not harboring IncFI, and it is found in an inverted orientation; (iv) the hly determinants are located on the chromosome, and their genetic organization is well conserved and closely resembles that of the reference hemolytic plasmid pHly152; and (v) Hly- mutants obtained by transposon insertion mutagenesis are not cytotoxic to HeLa cell monolayers, indicating that hemolysin is responsible for the high cytotoxic activity we have previously reported for these strains. The structural organization of the plasmid-encoded aer operon, together with the finding that those plasmids also carry antibiotic resistance genes, indicates that the IncFI plasmid of the NLF O4 E. coli strains studied more closely resembles aer-encoding virulence IncFI Salmonella R plasmids than E. coli ColV plasmids. The data presented here cannot rule out whether the strains examined are potentially intestinal or extraintestinal pathogens. Nevertheless, the genetic organization of the virulence genes, together with the epidemiological behavior and the wide spectrum of antibiotic resistance of the NLF O4 E. coli strains, indicates that these strains are structured as typical E. coli pathogenic isolates of human origin

In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa

The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required. In order to identify new candidates as potential drug targets, we combined large-scale transposon mutagenesis data analysis and bioinformatics predictions to retrieve a set of putative essential genes which are conserved in P. aeruginosa and predicted to encode cell envelope or secreted proteins. By generating unmarked deletion or conditional mutants, we confirmed the in vitro essentiality of two periplasmic proteins, LptH and LolA, responsible for lipopolysaccharide and lipoproteins transport to the outer membrane respectively, and confirmed that they are important for cell envelope stability. LptH was also found to be essential for P. aeruginosa ability to cause infection in different animal models. Conversely, LolA-depleted cells appeared only partially impaired in pathogenicity, indicating that this protein likely plays a less relevant role during bacterial infection. Finally, we ruled out any involvement of the other six proteins under investigation in P. aeruginosa growth, cell envelope stability and virulence. Besides proposing LptH as a very promising drug target in P. aeruginosa, this study confirms the importance of in vitro and in vivo validation of potential essential genes identified through random transposon mutagenesis