Erythema nodosum as a result of estrogen patch therapy for prostate cancer: a case report.

© 2015 Coyle et al.Introduction: Erythema nodosum is often associated with a distressing symptomatology, including painful subcutaneous nodules, polyarthropathy, and significant fatigue. Whilst it is a well-documented side-effect of estrogen therapy in females, we describe what we believe to be the first report in the literature of erythema nodosum as a result of estrogen therapy in a male. Case presentation: A 64-year-old Afro-Caribbean man with locally advanced carcinoma of the prostate agreed to participate in a randomized controlled trial comparing estrogen patches with luteinizing hormone-releasing hormone analogs to achieve androgen deprivation, and was allocated to the group receiving estrogen patches. One month later he presented with tender lesions on his shins and painful swelling of his ankles, wrists, and left shoulder. This was followed by progressive severe fatigue that required hospital admission, where he was diagnosed with erythema nodosum by a rheumatologist. Two months after discontinuing the estrogen patches the erythema nodosum, and associated symptoms, had fully resolved, and to date he remains well with no further recurrence. Conclusion: Trial results may establish transdermal estrogen as an alternative to luteinizing hormone-releasing hormone analogs in the management of prostate cancer, and has already been established as a therapy for male to female transsexuals. It is essential to record the toxicity profile of transdermal estrogen in men to ensure accurate safety information. This case report highlights a previously undocumented toxicity of estrogen therapy in men, of which oncologists, urologists, and endocrinologists need to be aware. Rheumatologists and dermatologists should add estrogen therapy to their differential diagnosis of men presenting with erythema nodosum

Distributed XQuery

XQuery is increasingly being used for ad-hoc integration of heterogeneous data sources that are logically mapped to XML. For example, scientists need to query multiple scientific databases, which are distributed over a large geographic area, and it is possible to use XQuery for that. However, the language currently supports only the data shipping query evaluation model (through the document() function): it fetches all data sources to a single server, then runs the query there. This is a major limitation for many applications, especially when some data sources are very large, or when a data source is only a virtual XML view over some other logical data model. We propose here a simple extension to XQuery that allows query shipping to be expressed in the language, in addition to data shipping

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones

Binary Decision Diagrams: from Tree Compaction to Sampling

Any Boolean function corresponds with a complete full binary decision tree. This tree can in turn be represented in a maximally compact form as a direct acyclic graph where common subtrees are factored and shared, keeping only one copy of each unique subtree. This yields the celebrated and widely used structure called reduced ordered binary decision diagram (ROBDD). We propose to revisit the classical compaction process to give a new way of enumerating ROBDDs of a given size without considering fully expanded trees and the compaction step. Our method also provides an unranking procedure for the set of ROBDDs. As a by-product we get a random uniform and exhaustive sampler for ROBDDs for a given number of variables and size

The hippo signaling pathway: implications for heart regeneration and disease

Control of cell number and organ size is critical for appropriate development and tissue homeostasis. Studies in both Drosophila and mammals have established the Hippo signaling pathway as an important modulator of organ size and tumorigenesis. Upon activation, this kinase cascade modulates gene expression through the phosphorylation and inhibition of transcription co-activators that are involved in cell proliferation, differentiation, growth and apoptosis. Hippo signaling serves to limit organ size and suppress malignancies, and has been implicated in tissue regeneration following injury. These outcomes highlight the important role that Hippo signaling plays in regulating both physiologic and pathologic processes. In this review, an overview of the signaling pathway will be discussed as well as recent work that has investigated its role in cardiac development, regeneration and disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40169-014-0027-0) contains supplementary material, which is available to authorized users

The radial metallicity gradients in the Milky Way thick disk as fossil signatures of a primordial chemical distribution

In this letter we examine the evolution of the radial metallicity gradient induced by secular processes, in the disk of an $N$-body Milky Way-like galaxy. We assign a [Fe/H] value to each particle of the simulation according to an initial, cosmologically motivated, radial chemical distribution and let the disk dynamically evolve for 6 Gyr. This direct approach allows us to take into account only the effects of dynamical evolution and to gauge how and to what extent they affect the initial chemical conditions. The initial [Fe/H] distribution increases with R in the inner disk up to R ~ 10 kpc and decreases for larger R. We find that the initial chemical profile does not undergo major transformations after 6 Gyr of dynamical evolution. The final radial chemical gradients predicted by the model in the solar neighborhood are positive and of the same order of those recently observed in the Milky Way thick disk. We conclude that: 1) the spatial chemical imprint at the time of disk formation is not washed out by secular dynamical processes, and 2) the observed radial gradient may be the dynamical relic of a thick disk originated from a stellar population showing a positive chemical radial gradient in the inner regions.Comment: 10 pages, 5 figures, Accepted for publication on Astrophysical Journal Letter

Spiralling dynamics near heteroclinic networks

There are few explicit examples in the literature of vector fields exhibiting complex dynamics that may be proved analytically. We construct explicitly a {two parameter family of vector fields} on the three-dimensional sphere \EU^3, whose flow has a spiralling attractor containing the following: two hyperbolic equilibria, heteroclinic trajectories connecting them {transversely} and a non-trivial hyperbolic, invariant and transitive set. The spiralling set unfolds a heteroclinic network between two symmetric saddle-foci and contains a sequence of topological horseshoes semiconjugate to full shifts over an alphabet with more and more symbols, {coexisting with Newhouse phenonema}. The vector field is the restriction to \EU^3 of a polynomial vector field in \RR^4. In this article, we also identify global bifurcations that induce chaotic dynamics of different types.Comment: change in one figur

Highlights of the SLD Physics Program at the SLAC Linear Collider

Starting in 1989, and continuing through the 1990s, high-energy physics witnessed a flowering of precision measurements in general and tests of the standard model in particular, led by e+e- collider experiments operating at the Z0 resonance. Key contributions to this work came from the SLD collaboration at the SLAC Linear Collider. By exploiting the unique capabilities of this pioneering accelerator and the SLD detector, including a polarized electron beam, exceptionally small beam dimensions, and a CCD pixel vertex detector, SLD produced a broad array of electroweak, heavy-flavor, and QCD measurements. Many of these results are one of a kind or represent the world's standard in precision. This article reviews the highlights of the SLD physics program, with an eye toward associated advances in experimental technique, and the contribution of these measurements to our dramatically improved present understanding of the standard model and its possible extensions.Comment: To appear in 2001 Annual Review of Nuclear and Particle Science; 78 pages, 31 figures; A version with higher resolution figures can be seen at http://www.slac.stanford.edu/pubs/slacpubs/8000/slac-pub-8985.html; Second version incorporates minor changes to the tex

On the Complexity of an Unregulated Traffic Crossing

The steady development of motor vehicle technology will enable cars of the near future to assume an ever increasing role in the decision making and control of the vehicle itself. In the foreseeable future, cars will have the ability to communicate with one another in order to better coordinate their motion. This motivates a number of interesting algorithmic problems. One of the most challenging aspects of traffic coordination involves traffic intersections. In this paper we consider two formulations of a simple and fundamental geometric optimization problem involving coordinating the motion of vehicles through an intersection. We are given a set of $n$ vehicles in the plane, each modeled as a unit length line segment that moves monotonically, either horizontally or vertically, subject to a maximum speed limit. Each vehicle is described by a start and goal position and a start time and deadline. The question is whether, subject to the speed limit, there exists a collision-free motion plan so that each vehicle travels from its start position to its goal position prior to its deadline. We present three results. We begin by showing that this problem is NP-complete with a reduction from 3-SAT. Second, we consider a constrained version in which cars traveling horizontally can alter their speeds while cars traveling vertically cannot. We present a simple algorithm that solves this problem in $O(n \log n)$ time. Finally, we provide a solution to the discrete version of the problem and prove its asymptotic optimality in terms of the maximum delay of a vehicle

Multiple Object Tracking in Urban Traffic Scenes with a Multiclass Object Detector

Multiple object tracking (MOT) in urban traffic aims to produce the trajectories of the different road users that move across the field of view with different directions and speeds and that can have varying appearances and sizes. Occlusions and interactions among the different objects are expected and common due to the nature of urban road traffic. In this work, a tracking framework employing classification label information from a deep learning detection approach is used for associating the different objects, in addition to object position and appearances. We want to investigate the performance of a modern multiclass object detector for the MOT task in traffic scenes. Results show that the object labels improve tracking performance, but that the output of object detectors are not always reliable.Comment: 13th International Symposium on Visual Computing (ISVC