Dvije slavenske tiskovine u zbirci Tornieri u biblioteci Bertoliana

L’autrice descrive il modo in cui durante la catalogazione delle edizioni del XVI secolo, presenti nella Biblioteca Civica Bertoliana di Vicenza sono stati riscoperti i due paleotipi slavi, oggetto della presente pubblicazione e di quella di K. Stantchev, ed e stata individuata la loro appartenenza storica alla collezione libraria del conte Arnaldo Tornieri al quale viene dedicato un paragrafo a parte (§2). Viene presentata in breve la storia della Biblioteca Bertoliana (§3), fondata nell’ a. 1708, e la situazione odierna delle sue collezioni (§4) con speciale riguardo a quelle documentarie e alle edizioni antiche e rare.Autorica opisuje na koji su način prilikom katalogizacije izdanja iz 16. stoljeća u Biblioteci Civica Bertoliana u Vicenzi pronađene dvije slavenske tiskovine, o kojima u svome članku piše Krassimir Stantchev. Istaknuta je njihova pripadnost zbirci knjiga grofa Arnalda Tornierija čemu je posvećen jedan odlomak (§2). Ukratko je opisana i povijest Biblioteke Bertoliana (§3), osnovane 1708. godine, današnje stanje njezinih zbirki (§4) s osobitim osvrtom na zbirke dokumenata te stara i rijetka izdanja

Procedimiento para el diseño de carcasas soldadas para cajas reductoras de media y alta potencia con optimización de los parámetros geométricos principales

La presente tesis tuvo por objetivo el procedimiento para el diseño y desarrollo de carcasas soldadas para cajas reductoras de ejes paralelos y engranajes cilíndricos. Si bien no se trató a profundidad el tema de los componentes internos de la transmisión, se realizaron cálculos aproximados de resistencia para el dimensionamiento general de los componentes para un caso particular de estudio. Se obtuvieron valores de fuerzas de reacción y dimensiones con lo cual se pudo obtener la geometría básica de la carcasa. A partir de dicha geometría se procedió a realizar una serie de análisis por elementos finitos buscando mitigar esfuerzos más altos y reduciendo áreas del diseño básico que no trabajaban bajo casi ningún esfuerzo. De esta forma se cambió la geometría de la carcasa sin cambiar los parámetros principales, realizando meramente cambios geométricos locales, con la finalidad de transmitir la mayor carga posible. Una vez establecidos los parámetros geométricos principales se procedió a optimizar los espesores, las fuerzas de pre ajuste, el número de tornillos, así como el tamaño de garganta de los cordones de soldadura. De esta forma se obtuvo un factor de seguridad no menor a 2 en cualquier punto de la carcasa, lo que traería consigo una reducción del material. Finalmente, dados los resultados obtenidos en la aplicación particular, se pudo concluir que el procedimiento desarrollado de forma teórica en los capítulos previos puede ser usado como referencia para el diseño de carcasas soldadas para cajas reductoras.Tesi

Stratigraphic evolution of the Triassic\u2013Jurassic succession in the Western Southern Alps (Italy) : the record of the two-stage rifting on the distal passive margin of Adria

The Triassic-Lower Jurassic succession of the Southern Alps is characterized by rapid thickness changes, from an average of about 5000m east of Lago Maggiore to about 500m in the Western Southern Alps. The stratigraphy reflects the Triassic evolution of the Tethyan Gulf and the Early Jurassic rifting responsible for the Middle Jurassic break-up of Adria from Europe. The succession of the Western Southern Alps starts with Lower Permian volcanics directly covered by Anisian sandstones. The top of the overlying Ladinian dolostones (300m) records subaerial exposure and karstification. Locally (Gozzano), Upper Sinemurian sediments cover the Permian volcanics, documenting pre-Sinemurian erosion. New biostratigraphic data indicate a latest Pliensbachian-Toarcian age for the Jurassic synrift deposits that unconformably cover Ladinian or Sinemurian sediments. Therefore, in the Western Southern Alps, the major rifting stage that directly evolved into the opening of the Penninic Ocean began in the latest Pliensbachian-Toarcian. New data allowed us to refine the evolution of the two previously recognized Jurassic extensional events in the Southern Alps. The youngest extensional event (Western Southern Alps) occurred as tectonic activity decreased in the Lombardy Basin. During the Sinemurian the Gozzano high represents the western shoulder of a rift basin located to the east (Lombardy). This evolution documents a transition from diffuse early rifting (Late Hettangian-Sinemurian), controlled by older discontinuities, to rifting focused along a rift valley close to the Pliensbachian-Toarcian boundary. This younger rift bridges the gap between the Hettangian-Sinemurian diffuse rifting and the Callovian-Bathonian break-up. The late Pliensbachian-Toarcian rift, which eventually lead to continental break-up, is interpreted as the major extensional episode in the evolution of the passive margin of Adria. The transition from diffuse to focused extension in the Southern Alps is comparable to the evolution of the Central Austroalpine during the Early Jurassic and of the Central and Northern Atlantic margins

Deciphering the state of the late Miocene to early Pliocene equatorial Pacific

The late Miocene-early Pliocene was a time of global cooling and the development of modern meridional thermal gradients. Equatorial Pacific sea surface conditions potentially played an important role in this global climate transition, but their evolution is poorly understood. Here, we present the first continuous late Miocene-early Pliocene (8.0-4.4 Ma) planktic foraminiferal stable isotope records from eastern equatorial Pacific Integrated Ocean Drilling Program Site U1338, with a new astrochronology spanning 8.0-3.5 Ma. Mg/Ca analyses on surface dwelling foraminifera Trilobatus sacculifer from carefully selected samples suggest mean sea-surface-temperatures (SSTs) are ~27.8±1.1°C (1σ) between 6.4-5.5 Ma. The planktic foraminiferal δ18O record implies a 2°C cooling between 7.2-6.1 Ma and an up to 3°C warming between 6.1-4.4 Ma, consistent with observed tropical alkenone paleo-SSTs. Diverging fine-fraction-to-foraminiferal δ13C gradients likely suggest increased upwelling from 7.1-6.0 and 5.8-4.6 Ma, concurrent with the globally recognized late Miocene Biogenic Bloom. This study shows that both warm and asymmetric mean states occurred in the equatorial Pacific during the late Miocene-early Pliocene. Between 8.0-6.5 and 5.2-4.4 Ma, low east-west δ18O and SST gradients and generally warm conditions prevailed. However, an asymmetric mean climate state developed between 6.5-5.7 Ma, with larger east-west δ18O and SST gradients and eastern equatorial Pacific cooling. The asymmetric mean state suggests stronger trade winds developed, driven by increased meridional thermal gradients associated with global cooling and declining atmospheric pCO2 concentrations. These oscillations in equatorial Pacific mean state are reinforced by Antarctic cryosphere expansion and related changes in oceanic gateways (e.g., Central American Seaway/Indonesian Throughflow restriction)

Did Photosymbiont Bleaching Lead to the Demise of Planktic Foraminifer Morozovella at the Early Eocene Climatic Optimum?

The symbiont-bearing mixed-layer planktic foraminiferal genera Morozovella and Acarinina were among the most important calcifiers of early Paleogene tropical–subtropical oceans. A marked and permanent switch in the abundance of these genera is known to have occurred at low-latitude sites at the beginning of the Early Eocene Climatic Optimum(EECO), such that the relative abundance of Morozovella permanently and significantly decreased along with a progressive reduction in the number of species; concomitantly, the genus Acarinina almost doubled its abundance and diversified. Here we examine planktic foraminiferal assemblages and stable isotope compositions of their tests at Ocean Drilling Program Site 1051 (northwest Atlantic) to detail the timing of this biotic event, to document its details at the species level, and to test a potential cause: the loss of photosymbionts (bleaching). We also provide stable isotope measurements of bulk carbonate to refine the stratigraphy at Site 1051 and to determine when changes in Morozovella species composition and their test size occurred. We demonstrate that the switch in Morozovella and Acarinina abundance occurred rapidly and in coincidence with a negative carbon isotope excursion known as the J event (~53 Ma), which marks the start of the EECO.We provide evidence of photosymbiont loss after the J event from a size-restricted δ13C analysis. However, such inferred bleaching was transitory and also occurred in the acarininids. The geologically rapid switch in planktic foraminiferal genera during the early Eocene was a major evolutionary change within marine biota, but loss of photosymbionts was not the primary causal mechanism

Kitesi

Busca resolver la falta de educación sexual en la currícula de los colegios de Lima Metropolitana, teniendo como población beneficiaria adolescentes de 14 a 17 años

Non-small cell lung cancer testing on reference specimens: an italian multicenter experience

Introduction: Biomarker testing is mandatory for the clinical management of patients with advanced non-small cell lung cancer (NSCLC). Myriads of technical platforms are now available for biomarker analysis with differences in terms of multiplexing capability, analytical sensitivity, and turnaround time (TAT). We evaluated the technical performance of the diagnostic workflows of 24 representative Italian institutions performing molecular tests on a series of artificial reference specimens built to mimic routine diagnostic samples. Methods: Sample sets of eight slides from cell blocks of artificial reference specimens harboring exon 19 EGFR (epidermal growth factor receptor) p.E746_AT50del, exon 2 KRAS (Kirsten rat sarcoma viral oncogene homologue) p.G12C, ROS1 (c-ros oncogene 1)-unknown gene fusion, and MET (MET proto-oncogene, receptor tyrosine kinase) Δ exon 14 skipping were distributed to each participating institution. Two independent cell block specimens were validated by the University of Naples Federico II before shipment. Methodological and molecular data from reference specimens were annotated. Results: Overall, a median DNA concentration of 3.3 ng/μL (range 0.1–10.0 ng/μL) and 13.4 ng/μL (range 2.0–45.8 ng/μL) were obtained with automated and manual technical procedures, respectively. RNA concentrations of 5.7 ng/μL (range 0.2–11.9 ng/μL) and 9.3 ng/μL (range 0.5–18.0 ng/μL) were also detected. KRAS exon 2 p.G12C, EGFR exon 19 p.E736_A750del hotspot mutations, and ROS1 aberrant transcripts were identified in all tested cases, whereas 15 out of 16 (93.7%) centers detected MET exon 14 skipping mutation. Conclusions: Optimized technical workflows are crucial in the decision-making strategy of patients with NSCLC. Artificial reference specimens enable optimization of diagnostic workflows for predictive molecular analysis in routine clinical practice

Stereotypes and emotions about cultural otherness through skin color. Dark skinned children's point of view.

openLo scopo di questo elaborato, che rientra nel filone di studi capeggiato dalla ricerca dell’antropologa Paola Tabet, è quello di indagare la percezione dell’alterità culturale nei bambini con pelle scura. Nello specifico, questa tesi si occupa di analizzare i pensieri e le emozioni che i bambini con pelle scura hanno espresso, tramite la stesura di brevi temi, che hanno chiesto loro come si sentirebbero se i loro compagni cambiassero colore di pelle. Tramite l’analisi di questi è possibile comprendere il punto di vista dei bambini e l’eventuale presenza di stereotipi e pregiudizi nei confronti del diverso, sviluppando una riflessione sul progetto educativo interculturale italiano.The purpose of this paper, which falls within the research stream led by the anthropologist Paola Tabet, is to investigate the perception of cultural otherness in children with dark skin. Specifically, this thesis aims to analyze the thoughts and emotions that children with dark skin have expressed through the writing of short essays, which asked them how they would feel if their classmates changed skin color. Through the analysis of these essays, it is possible to understand the children's point of view and the potential presence of stereotypes and prejudices towards those who are different, thereby developing a reflection on the Italian intercultural educational project