Tie- ja raideliikennemelun terveys- ja hyvinvointivaikutukset Kuopiossa ja Jyväskylässä

Julkaisu oli 4.2.22 asti tuplana, kahtena tietueena. Toisen tietueen latausmäärä tuolloin 489 kertaa. Poistetun URN yhdistyy nyt tähän tietueeseen

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward β cell failure, and factors determining time of presentation of clinical diabetes are poorly understood. We investigated changes in the serum metabolome prospectively in children who later progressed to type 1 diabetes. Serum metabolite profiles were compared between sample series drawn from 56 children who progressed to type 1 diabetes and 73 controls who remained nondiabetic and permanently autoantibody negative. Individuals who developed diabetes had reduced serum levels of succinic acid and phosphatidylcholine (PC) at birth, reduced levels of triglycerides and antioxidant ether phospholipids throughout the follow up, and increased levels of proinflammatory lysoPCs several months before seroconversion to autoantibody positivity. The lipid changes were not attributable to HLA-associated genetic risk. The appearance of insulin and glutamic acid decarboxylase autoantibodies was preceded by diminished ketoleucine and elevated glutamic acid. The metabolic profile was partially normalized after the seroconversion. Autoimmunity may thus be a relatively late response to the early metabolic disturbances. Recognition of these preautoimmune alterations may aid in studies of disease pathogenesis and may open a time window for novel type 1 diabetes prevention strategies

Seksuaalinen häirintä kauneudenhoitoalalla : opintokokonaisuus

Seksuaalista häirintää esiintyy kaikilla työelämän osa-alueilla ja asia nousee aina ajoittain median otsikoihin. Tutkimusten mukaan häirintää on kokenut joka toinen 15–34 -vuotias nainen. Kauneudenhoitoalalla työskentelevät omasta ulkonäöstään huolehtivat naiset ovat todennäköinen häirinnän kohteeksi joutuva ryhmä ja tämän opinnäytetyön mielenkiinnon kohde. Seksuaalista häirintää esiintyy myös oppilaitoksissa. Useimmiten häirintä tapahtuu alaikäisten kesken, harvemmin opettajan ja alaikäisen välillä. Kouluissa häirintätapaukset paljastuvat yleensä helpommin kuin työpaikoilla. Oma tutkimus tehtiin Pinni lehden avustuksella. Lehden nettisivulla tehtyyn kyselyyn vastasi kesän 2012 aikana 74 henkilöä. Kysymyksenä oli: ”Oletko joutunut seksuaalisen häirinnän kohteeksi asiakkaan, työkaverin tai esimiehen taholta?” Kyselyn tuloksena 53 % vastasi ”en lainkaan”, 42 % vastasi ”joskus” ja 5 % vastasi ”kyllä, usein”. Tutkimuksen kvalitatiivinen osuus sisälsi haastattelujen lisäksi mahdollisuuden kertoa oma kokemuksensa vapaasti. Laadulliseen tutkimukseen saatiin 18 vastausta. Näiden tutkimusten perusteella vahvistui käsitys siitä, että kauneudenhoitoalalla esiintyy seksuaalista häirintää. Tutkimusaineiston analysoinnissa hyödynnettiin kattavan asiantuntijaverkoston tietoa ja erityisosaamista. Asiantuntijoina oli seksuaaliterapeutteja, seksuaalipedagogi, seksuaalineuvoja, kuraattoreita, terveydenhoitaja ja poliisi. Lisäksi otettiin yhteys rikosuhripäivystykseen sekä juridiikan asiantuntijaan. Opinnäytetyön päämääränä oli tuottaa 2 opintoviikon mittainen opintokokonaisuus kehittämään erityisesti kauneudenhoitoalan terveystiedon opintoja. Tämä opintokokonaisuus tukee nuorten seksuaalista hyvinvointia. Opintomateriaalissa käsitellään seksuaalisen häirinnän esiintymistapoja ja sen kohtaamista. Lisäksi harjoitellaan käytännön toimintaohjeita seksuaalista häirintää kohdattaessa. Opinnäytetyön tarkoituksena on tuoda tärkeä asia esille ja nostaa valmiutta kohdata mahdollinen häirintä kauneudenhoitoalalla.Sexual harassment appears in every sector of working life and occasionally topic reaches media headlines. According to the researches every other 15-34 –year old woman has experienced sexual harassment. Women who work in beauty business take care of their appearance. They are likely victims to sexual harassment and main interest of this thesis. Sexual harassment appears also in educational institutions. Usually harassment takes place between students, rarely between teacher and student. Harassment cases are usually exposed more easily in schools than in workplaces. Research was done with assistance of the magazine Pinni. During summer 2012 74 people answered to the query in the magazine’s website. The question was: “Have you ever been the victim of sexual harassment by customer, co-worker or superior?” The query results: 53% answered “never”, 42% answered “sometimes” and 5% answered “yes, often”. In addition, the inquiry´s qualitative part contained a possibility to freely share own experience about sexual harassment. This part was answered by 18 participants. The study strengthened perception that sexual harassment appears in beauty care. Knowledge and special expertise of comprehensive web of experts was needed to analyze results. Experts were sexual therapists, sexuality educator, sexual adviser, curators, health nurse and police. Criminal victim support and juridical expert was also contacted. Goal of the thesis was to produce study module which would develop health education especially in beauty care studies. This study module supports youth´s sexual well-being. Study material deals with the forms of appearance of sexual harassment and how to face it. Practical guidance is also given. The purpose of the study module is to bring up this important thing and raise the preparedness to face possible harassment in beauty care

Maturity and hygiene quality of composts and hygiene indicators in agricultural soil fertilised with municipal waste or manure compost

Composts produced from municipal source separated biowaste (Biowaste), a mixture of biowaste and anaerobically digested sewage sludge (Biosludge) and cattle manure (Manure) were examined for their maturity and hygiene quality. The composts were applied to a potato crop in 2004 and to a barley nurse crop of forage ley in 2005 in a field experiment. Numbers of faecal coliforms, enterococci, clostridia and Salmonella in field soil were determined 2 weeks and 16 weeks after compost applications. Municipal compost batches chosen based on successful processing showed variable maturity during field application, and the need to evaluate compost maturity with multiple variables was confirmed. The numbers of faecal coliform were similar in all compost types, averaging 4.7 and 2.3 log 10 CFU g-1 in the first and second years, respectively. The highest number of enterococci was 5.2 log10 CFU g-1, found in Manure compost in the first year, while the highest clostridia numbers were found in Biosludge compost, averaging 4.0 log10 CFU g -1 over both years. Except for one case, less than 2.4 log10 CFU g-1 of faecal coliforms or clostridia were found in compost-fertilised soil, while the numbers of enterococci were mostly higher than in unfertilised soil (&lt;4.2 or &lt;3.2 log10 CFU g-1, respectively). No hygiene indicator bacteria were present in compost-fertilised potato at harvest. Overall, compost fertilisations caused rather small changes in the counts of hygiene indicators in the field environment. </jats:p

Maturity and hygiene quality of composts and hygiene indicators in agricultural soil fertilised with municipal waste or manure compost

v2011o