A Honeynet within the German Research Network – Experiences and Results

A honeynet is a special prepared network which is not used in normal business. It is a kind of playground to watch and learn the tactics of crackers. The only purpose of a honeynet is to be probed, attacked or compromised. During the operation other systems may not be harmed by an attack originated within the honeynet. In this paper the design, realization and operation of a honeynet built within the German Research Network (DFN) will be described. Concepts for continuously monitoring and securing the honeynet are introduced. A selection of the results of the operation phase will be presented as well

Evaluation of an Accounting Model for Dynamic Virtual Organizations

Accounting of Grid resource and service usage determines the central support activity for Grid systems to be adopted as a means for service-oriented computing in Dynamic Virtual Organizations (DVO). An all-embracing study of existing Grid accounting systems has revealed that these approaches focus primarily on technical precision, while they lack a foundation of appropriate economic accounting principles and the support for multi-provider scenarios or virtualization concepts. Consequently, a new, flexible, resource-based accounting model for DVOs was developed, combining technical and economic accounting by means of Activity-based Costing. Driven by a functional evaluation, this paper pursues a full-fledged evaluation of the new, generically applicable Grid accounting model. This is done for the specific environment of the Leibniz Supercomputing Centre (LRZ) in Garching, Germany. Thus, a detailed evaluation methodology and evaluation environment is outlined, leading to actual model-based cost calculations for a defined set of considered Grid services. The results gained are analyzed and respective conclusions on model applicability, optimizations, and further extensions are draw

Welfare of fishes in aquaculture

Final report of the European Inland Fisheries and Aquaculture Advisory Commission (EIFAAC) project “Welfare of Fishes in Aquaculture” 2014–2018.201

Welfare of fishes in aquaculture

The welfare of fish in aquaculture is of increasing public concern in Europe and thus of growing importance for fish farmers. Although the topic can be regarded as controversial, due in particular to the lack of available knowledge, there is nevertheless an urgent need for fish farmers, authorities and scientists to develop criteria, approaches and practices to monitor and safeguard the welfare of cultured fish. The objective of this document is to provide the opinion of EIFAAC Member institutions– as the reference body in the field of inland fisheries and aquaculture – on how, given the current state of scientific knowledge, fish welfare issues can be integrated into best practice guidelines for fish culture. This report deals with the welfare of farmed finfish and neither addresses capture fisheries, be they commercial or recreational, nor welfare issues related to the culture of crustaceans and molluscs. The report focuses on the welfare issues of on-growing fish while giving little to no attention to larvae/fry and broodstock. Likewise, the report focuses primarily on the culture conditions for farming of fish and gives little attention to welfare aspects related to transport and slaughter. Finally, emphasis is given to the culture of freshwater fish, but marine species are included where appropriate. It is understood that the principal welfare issues are comparable for freshwater and marine fish culture. The report is, as much as possible, generic, not focusing on species-specific issues (except where absolutely necessary). However, unavoidably, the report is biased due to the fact that the available information on welfare issues is not equally distributed across fish species

Advancing the Security of LDACS

The "Single European Sky" air traffic management master plan foresees the introduction of several modern digital data links for aeronautical communications. The candidate for long-range continental communications is the L-band Digital Aeronautical Communications System (LDACS). LDACS is a cellular, ground-based digital communications system for flight guidance and communications related to safety and regularity of flight. Hence, the aeronautical standards, imposed by the International Civil Aviation Organization (ICAO), for cybersecurity of the link and network layer, apply. In previous works, threat-and risk analyses of LDACS were conducted, a draft for an LDACS cybersecurity architecture introduced, algorithms proposed, and the security of a Mutual Authentication and Key Establishment (MAKE) procedure of LDACS formally verified. However, options for cipher-suites and certificate management for LDACS were missing. Also, previous works hardly discussed the topic of post-quantum security for LDACS. This paper proposes a cell-attachment procedure, which establishes a secure LDACS communication channel between an aircraft and corresponding ground-station upon cell-entry of the aircraft. Via the design of a hybrid LDACS Public Key Infrastructure (PKI), the choice of a pre-or post-quantum Security Level (SL) is up to the communications participants. With that, this work introduces a full LDACS cell-attachment protocol based on a PKI, certificates, certificate revocation and cipher-suites including pre-and post-quantum options. Evaluations in the symbolic model show the procedure to fulfill LDACS security requirements and a communications performance evaluation demonstrates feasibility, matching requirements imposed by regulatory documents

StellaTUM: current consensus and discussion on pancreatic stellate cell research

The field of pancreatic stellate cell (PSC) biology is very young, as the essential in-vitro tools to study these cells (ie, methods to isolate and culture PSC) were only developed as recently as in 1998. Nonetheless, there has been an exponential increase in research output in this field over the past decade, with numerous research groups around the world focusing their energies into elucidating the biology and function of these cells. It is now well established that PSC are responsible for producing the stromal reaction (fibrosis) of two major diseases of the pancreas—chronic pancreatitis and pancreatic cancer. Despite exponentially increasing data, the methods for studying PSC remain variable. Although within individual laboratories methods are consistent, different methodologies used by various research groups make it difficult to compare results and conclusions. This article is not a review article on the functions of PSC. Instead, members of the Pancreatic Star Alliance (http://www.pancreaticstaralliance.com) discuss here and consolidate current knowledge, to outline and delineate areas of consensus or otherwise (eg, with regard to methodological approaches) and, more importantly, to identify essential directions for future research

Detection of novel biomarkers of liver cirrhosis by high performance proteomics

Comunicaciones a congreso

Влияние рыночного механизма на развитие социальной системы

Hepatic cirrhosis is a life-threatening disease arising from different chronic liver disorders. One major cause for hepatic cirrhosis is chronic hepatitis C. Chronic hepatitis C is characterized by a highly variable clinical course, with at least 20% developing liver cirrhosis within 40 years. Only liver biopsy allows a reliable evaluation of the course of hepatitis C by grading inflammation and staging fibrosis, and thus serum biomarkers for hepatic fibrosis with high sensitivity and specificity are needed. To identify new candidate biomarkers for hepatic fibrosis, we performed a proteomic approach of microdissected cirrhotic septa and liver parenchyma cells. In cirrhotic septa, we detected an increasing expression of cell structure associated proteins, including actin, prolyl 4-hydroxylase, tropomyosin, calponin, transgelin, and human microfibril–associated protein 4 (MFAP-4). Tropomyosin, calponin, and transgelin reflect a contribution of activated stellate cells/myofibroblasts to chronic liver injury. The expression of tropomyosin, transgelin, and MFAP-4, an extracellular matrix associated protein, were further evaluated by immunohistochemistry. Tropomyosin and MFAP-4 demonstrated high serum levels in patients with hepatic cirrhosis of different causes. CONCLUSION: A quantitative analysis of MFAP-4 serum levels in a large number of patients showed MFAP-4 as novel candidate biomarker with high diagnostic accuracy for prediction of nondiseased liver versus cirrhosis [area under receiver operating characteristic curve (AUC) = 0.97, P < 0.0001] as well as stage 0 versus stage 4 fibrosis (AUC = 0.84, P < 0.0001), and stages 0 to 3 versus stage 4 fibrosis (AUC = 0.76, P < 0.0001)

Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis

Background: Interactions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP). Methods: Markers of fibrosis and inflammation were concomitantly analysed by immunohistochemistry in chronic pancreatitis tissues. In vitro, PSC were stimulated with TNFalpha and LPS. Primary human blood mononuclear cells (PBMC) and PSC were cocultured, followed by analysis of cytokines and extracellular matrix (ECM) proteins. PBMC were derived from healthy donors and CP and septic shock patients. Results: In areas of mononuclear cell infiltration in chronic pancreatitis tissues, there was decreased immunoreactivity for collagen1 and fibronectin, in contrast to areas with sparse mononuclear cells, although PSC were detectable in both areas. LPS and TNFalpha induced collagen1 and fibronectin levels as well as the matrix degradation enzyme MMP-1. Coculture experiments with PSC and PBMC revealed increased fibronectin secretion induced by PBMC. In addition, donor and CP PBMC significantly induced an increase in IL-6, MCP-1 and TGFbeta levels under coculture conditions. Determination of the source of cytokines and ECM proteins by mRNA expression analysis confirmed PSC as major contributors of ECM production. The increase in cytokine expression was PBMC- and also PSC-derived. Conclusion: Mononuclear cells modulate the activity of pancreatic stellate cells, which may in turn promote fibrosis and inflammation