708 research outputs found
Modeling of 2D and 3D Assemblies Taking Into Account Form Errors of Plane Surfaces
The tolerancing process links the virtual and the real worlds. From the
former, tolerances define a variational geometrical language (geometric
parameters). From the latter, there are values limiting those parameters. The
beginning of a tolerancing process is in this duality. As high precision
assemblies cannot be analyzed with the assumption that form errors are
negligible, we propose to apply this process to assemblies with form errors
through a new way of allowing to parameterize forms and solve their assemblies.
The assembly process is calculated through a method of allowing to solve the 3D
assemblies of pairs of surfaces having form errors using a static equilibrium.
We have built a geometrical model based on the modal shapes of the ideal
surface. We compute for the completely deterministic contact points between
this pair of shapes according to a given assembly process. The solution gives
an accurate evaluation of the assembly performance. Then we compare the results
with or without taking into account the form errors. When we analyze a batch of
assemblies, the problem is to compute for the nonconformity rate of a pilot
production according to the functional requirements. We input probable errors
of surfaces (position, orientation, and form) in our calculus and we evaluate
the quality of the results compared with the functional requirements. The pilot
production then can or cannot be validated
High-pressure operation of a xenon-GPSC/MSGC hybrid detector for hard X-ray spectrometry
The performance of a high-pressure xenon gas proportional scintillation counter/microstrip gas chamber (GPSC/MSGC) hybrid detector has been investigated for filling pressures from 1 up to 10 bar, for 22-, 30- and 60-keV photons. GPSC/MSGC hybrid detectors are based on a xenon-GPSC instrumented with a CsI-coated microstrip plate photosensor placed directly within the xenon envelope, as a substitute for the photomultiplier tube. This design avoids the constraints due to the use of a quartz scintillation window for GPSC-photosensor coupling, which absorbs a significant amount of scintillation and is a drawback for applications where large detection areas and high filling pressures are needed. The lowest energy resolutions are achieved for 2 bar (5.5% and 3.4%, FWHM, for 22- and 60-keV photons, respectively). Increasing the pressure to the 5-6 bar range, competitive energy resolutions of 7% and 4.5% are still achieved for 22- and 60-keV photons, respectively. This detector could be a compelling alternative in applications where compactness, large detection area, insensitivity to strong magnetic fields, room temperature operation, large signal-to-noise ratio and good energy resolution are important requirements.http://www.sciencedirect.com/science/article/B6TJM-4M3B6DG-8/1/04ba8b77386c4c69025c7ca19342f79
Evaluation of canine adipose-derived stem cells in a healthy mice subcutaneous model
Canine adipose-derived stem cells (cASCs) have great interest for cell-based therapies in Veterinary Medicine.
As the behaviour of these cells in non-autologous recipients is not deeply characterized, it is mandatory to study them in new animal models previously to canine specie. In this work, cASCs were injected subcutaneously in mice and these cells were detected by immunohistochemistry using vimentin, CD44 and keratin. The local response evaluated by histology did not reveal signals of significant inflammatory reaction neither in the lymph nodes or other organs.
This study showed the implantation of cASCs induced a scarce inflammatory response. Hsd:CD1 (ICR) mouse can be proposed as an animal model to study the in vivo behavior of the cASCs and to validate new cASCs-based approaches avoiding or reducing the use of dogs in research
Iterative Methods for Visualization of Implicit Surfaces on GPU
The original publication is available at www.springerlink.comInternational audienceThe ray-casting of implicit surfaces on GPU has been explored in the last few years. However, until recently, they were restricted to second degree (quadrics). We present an iterative solution to ray cast cubics and quartics on GPU. Our solution targets efficient implementation, obtaining interactive rendering for thousands of surfaces per frame. We have given special attention to torus rendering since it is a useful shape for multiple CAD models. We have tested four different iterative methods, including a novel one, comparing them with classical tessellation solution
Recent advances in X-ray detection with micro-hole and strip plate detector
We report on the performance of a micro-hole and strip plate, fabricated with standard gas electron multiplier-production procedures, presenting 40-[mu]m hole-diameter and 30-[mu]m wide anode strips. Multiplication factors of 5×104 were reached in an Ar/Xe (95/5) atmosphere at about 1 bar; the energy resolution is of the order of 14% (FWHM) for 5.9-keV X-rays.http://www.sciencedirect.com/science/article/B6TJM-4BRJY00-1/1/d80a918485bf806c1feae6bbd514d4e
Observation of coupled plasmon-polariton modes of plasmon waveguides for electromagnetic energy transport below the diffraction limit
We investigate the possibility of using arrays of closely spaced metal nanoparticles as plasmon waveguides for electromagnetic energy below the diffraction limit of light. Far-field spectroscopy on arrays of closely spaced 50 nm Au particles fabricated using electron beam lithography reveals the presence of near-field optical particle interactions that lead to shifts in the plasmon resonance frequencies for longitudinal and transverse excitations. We link this observation to a point-dipole model for energy transfer in plasmon waveguides and give an estimate of the expected group velocities and energy decay lengths for the fabricated structures. A near-field optical excitation and detection scheme for energy transport is proposed and demonstrated. The fabricated structures show a high propagation loss of about 3 dB / 15 nm which renders a direct experimental observation of energy transfer impossible. The nature of the loss and ways to decrease it by an order of magnitude are discussed. We also present finite-difference time-domain simulations on the energy transfer properties of plasmon waveguides
Optimization of supply diversity for the self-assembly of simple objects in two and three dimensions
The field of algorithmic self-assembly is concerned with the design and
analysis of self-assembly systems from a computational perspective, that is,
from the perspective of mathematical problems whose study may give insight into
the natural processes through which elementary objects self-assemble into more
complex ones. One of the main problems of algorithmic self-assembly is the
minimum tile set problem (MTSP), which asks for a collection of types of
elementary objects (called tiles) to be found for the self-assembly of an
object having a pre-established shape. Such a collection is to be as concise as
possible, thus minimizing supply diversity, while satisfying a set of stringent
constraints having to do with the termination and other properties of the
self-assembly process from its tile types. We present a study of what we think
is the first practical approach to MTSP. Our study starts with the introduction
of an evolutionary heuristic to tackle MTSP and includes results from extensive
experimentation with the heuristic on the self-assembly of simple objects in
two and three dimensions. The heuristic we introduce combines classic elements
from the field of evolutionary computation with a problem-specific variant of
Pareto dominance into a multi-objective approach to MTSP.Comment: Minor typos correcte
Convolution filtering of continuous signed distance fields for polygonal meshes
Signed distance fields obtained from polygonal meshes are commonly used in various applications. However, they can have C1 discontinuities causing creases to appear when applying operations such as blending or metamorphosis. The focus of this work is to efficiently evaluate the signed distance function and to apply a smoothing filter to it while preserving the shape of the initial mesh. The resulting function is smooth almost everywhere, while preserving the exact shape of the polygonal mesh. Due to its low complexity, the proposed filtering technique remains fast compared to its main alternatives providing C1-continuous distance field approximation. Several applications are presented such as blending, metamorphosis and heterogeneous modelling with polygonal meshes
Design and characterization of a biodegradable double-layer scaffold aimed at periodontal tissue-engineering applications
First published: 1 September 2013The inefficacy of the currently used therapies in achieving the regeneration ad integrum of the
periodontium stimulates the search for alternative approaches, such as tissue-engineering strategies.
Therefore, the core objective of this study was to develop a biodegradable double-layer scaffold for
periodontal tissue engineering. The design philosophy was based on a double-layered construct
obtained from a blend of starch and poly-ε-caprolactone (30:70 wt%; SPCL). A SPCL fibre mesh
functionalized with silanol groups to promote osteogenesis was combined with a SPCL solvent
casting membrane aiming at acting as a barrier against the migration of gingival epithelium into
the periodontal defect. Each layer of the double-layer scaffolds was characterized in terms of
morphology, surface chemical composition, degradation behaviour and mechanical properties.
Moreover, the behaviour of seeded/cultured canine adipose-derived stem cells (cASCs) was assessed.
In general, the developed double-layered scaffolds demonstrated adequate degradation and
mechanical behaviour for the target application. Furthermore, the biological assays revealed that
both layers of the scaffold allow adhesion and proliferation of the seeded undifferentiated cASCs,
and the incorporation of silanol groups into the fibre-mesh layer enhance the expression of a typical
osteogenic marker. This study allowed an innovative construct to be developed, combining a
three-dimensional (3D) scaffold with osteoconductive properties and with potential to assist
periodontal regeneration, carrying new possible solutions to current clinical needs
.The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013; under Grant Agreement No. REGPOT-CT2012-316331-POLARIS) and from the Portuguese Foundation for Science and Technology (FCT; Grant No, MIT/ECE/0047/2009). Joao Requicha acknowledges the FCT for his PhD scholarship ( Grant No. SFRH/BD/44143/2008)
GEM scintillation readout with avalanche photodiodes
The use of the scintillation produced in the charge avalanches in GEM holes as signal amplification and readout is investigated for xenon. A VUV-sensitive avalanche photodiode has been used as photosensor. Detector gains of about 4 × 104 are achieved in scintillation readout mode, for GEM voltages of 490 V and for a photosensor gain of 150. Those gains are more than one order of magnitude larger than what is obtained using charge readout. In addition, the energy resolutions achieved with the scintillation readout are lower than those achieved with charge readout. The GEM scintillation yield in xenon was measured as a function of GEM voltage, presenting values that are about a half of those achieved for the charge yield, and reach about 730 photons per primary electron at GEM voltages of 490 V
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