Summary of workshop large outdoor fires and the built environment

Large outdoorfires present a risk to the built environment. Wildfires that spread into communities, referred to as Wildland-Urban Interface (WUI)fires, havedestroyed communities throughout the world, and are an emerging problem infire safety science. Other examples are large urbanfires including those that haveoccurred after earthquakes. Research into large outdoorfires, and how to potentially mitigate the loss of structures in suchfires, lags other areas offire safety scienceresearch. At the same time, common characteristics betweenfire spread in WUIfires and urbanfires have not been fully exploited. In this paper, an overview of thelarge outdoorfire risk to the built environment from each region is presented. Critical research needs for this problem in the context offire safety scienceare provided.The present paper seeks to develop the foundation for an international research needs roadmap to reduce the risk of large outdoorfires to the built environment.Peer ReviewedPreprin

Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.

G-Quadruplex DNAs are folded, non-Watson-Crick structures that can form within guanine-rich DNA sequences such as telomeric repeats. Previous studies have identified a series of trisubstituted acridine derivatives that are potent and selective ligands for G-quadruplex DNA. These ligands have been shown previously to inhibit the activity of telomerase, the specialized reverse transcriptase that regulates telomere length. The RecQ family of DNA helicases, which includes the Bloom's (BLM) and Werner's (WRN) syndrome gene products, are apparently unique among cellular helicases in their ability to efficiently disrupt G-quadruplex DNA. This property may be relevant to telomere maintenance, since it is known that the sole budding yeast RecQ helicase, Sgs1p, is required for a telomerase-independent telomere lengthening pathway reminiscent of the "ALT" pathway in human cells. Here, we show that trisubstituted acridine ligands are potent inhibitors of the helicase activity of the BLM and WRN proteins on both G-quadruplex and B-form DNA substrates. Inhibition of helicase activity is associated with both a reduction in the level of binding of the helicase to G-quadruplex DNA and a reduction in the degree to which the G-quadruplex DNA can support DNA-dependent ATPase activity. We discuss these results in the context of the possible utility of trisubstituted acridines as antitumor agents for the disruption of both telomerase-dependent and telomerase-independent telomere maintenance

MULTICRITERIA OPTIMISATION METHODS IN LOGISTICS ON THE EXAMPLE OF WAREHOUSE LOCATION

Purpose: The purpose of the paper is to present the warehouse location as one of the key decision problems in logistics, a critical analysis of the centre of gravity method (commonly known and widely used) and to propose the more advanced methods to support the decision process in this area described in the contemporary publications on operational research, such as: AHP (Analytic Hierarchy Process), Simos’ method and entropy method.Methodology: The above purpose was realised by analysing the literature both from the logistics area, especially from one of its areas of activity which is warehousing and from operational research on the use of methods to support the warehouse location decision-making processes was made.Findings: The article outlines the warehouse location as one of the key decision problems in the area of logistics. It presents centre of gravity approach described in the literature of logistics and shows its advantages and disadvantages. Furthermore, because the warehouse location is multicriteria decision problem, the more advanced methods from the area of operational research were suggested, such as: AHP (Analytic Hierarchy Process), Simos’ method and entropy method.Implications: The methods proposed in the article allow to take many criteria into consideration in the warehouse location process and also make it more objective

Linking System of Care Services to Flourishing in School-Aged Children with Autism

Flourishing in children is an indicator of positive development in the areas of emotional, social, and cognitive development. Using a recent dataset from the US National Survey of Children’s Health, this study investigates the association between access to a quality healthcare system and flourishing indicators in school-aged children with autism. The outcome variable describes the proportion of children aged 6–17 with autism meeting the flourishing criteria, which include measures related to learning, resilience, and self-regulation. The main independent variable includes six core indicators for school-aged children and adolescents, which assess whether the family feels like a partner in their child’s care, the child has a medical home, receives regular medical and dental preventive care, has adequate insurance, has no unmet needs or barriers to accessing services, and has prepared for transition to adult healthcare. Multivariable logistic regression models were used to examine the relationships between various independent variables and the outcome of interest. The results show that children with autism who receive comprehensive and coordinated care are more likely to flourish compared to those without such care for five of these six indicators, while controlling for sex, race, parental education, household income, self-reported autism severity, general health status, and the number of adverse childhood experiences. Children with autism are more likely to flourish when their families and healthcare providers work together effectively. Addressing gaps in the quality care system is essential for developing holistic approaches that empower children with autism to thrive and reach their full potential. Supportive health policies and effective coordination between families and healthcare providers are crucial for fostering the flourishing of children with autism, ensuring comprehensive, individualized, and continuous care

Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

Functional SNPs selected for the study. Table S2. Restriction fragment analysis for BRCA1 mutations. Table S3. Oxidative stress parameters in breast cancer cases according to treatment. (DOCX 31 kb

A human MAP kinase interactome.

Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using small interfering RNA knockdowns, we observed that approximately one-third of MAPK-interacting proteins modulated MAPK-mediated signaling. We uncovered the Na-H exchanger NHE1 as a potential MAPK scaffold, found links between HSP90 chaperones and MAPK pathways and identified MUC12 as the human analog to the yeast signaling mucin Msb2. This study makes available a large resource of MAPK interactions and clone libraries, and it illustrates a methodology for probing signaling networks based on functional refinement of experimentally derived protein-interaction maps

PROXIMITY BASED MEETING DIAL-IN

A solution is provided that leverages a digital proximity-based mechanism to determine that a meeting is taking place and then to automatically trigger a notification (with a close group of colleagues) so that others may also join the meeting remotely

VISUAL FIDUCIALS FOR PRIVACY AND SECURITY

It can be difficult and time-consuming to maintain personal security and privacy while participating on-line video experiences. Many modifications can be provided post-production but this is unrealistic in the real-time world in which video/camera systems are often utilized. Presented herein is a technique for using a Quick Response (QR) code or other similar encoding mechanism within the field of view of a video/camera solution as a means to provide real-time/in-stream configuration of privacy and security zones. The encoding mechanism would contain all information necessary to define these zones. Once detected within the field of view, these zones would remain in effect until actively disabled

BREAKOUT DIALOG ANALYSIS FOR WEB CONFERENCING APPLICATIONS

Video conferencing applications typically only allow one person to talk at a time. This is perfect for meetings that are presentations, but may not be acceptable for virtual social events (e.g., happy hours ) or brainstorming type meetings where, in the physical world, people naturally break off to have smaller, more intimate meetings to discuss a specific topic. Recent advancements to video conferencing applications have enabled users to create sub-meetings where smaller discussions can take place within a greater meeting. However, these sub-meetings restrict users to only seeing and hearing the participants within that sub-meeting without any context of the other discussions occurring at the same time. Techniques herein may provide for displaying a list of the top words being used in different sub-meetings, which can help users to determine the topics being discussed and decide which sub-meeting they may desire to join