Age and structure parameters of a remote M31 globular cluster B514 based on HST, 2MASS, GALEX and BATC observations

B514 is a remote M31 globular cluster which locating at a projected distance of R_p~55 kpc. Deep observations with the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope (HST) are used to provide the accurate integrated light and star counts of B514. By coupling analysis of the distribution of the integrated light with star counts, we are able to reliably follow the profile of the cluster out to ~40". Based on the combined profile, we study in detail its surface brightness distribution in F606W and F814W filters, and determine its structural parameters by fitting a single-mass isotropic King model. The results showed that, the surface brightness distribution departs from the best-fit King model for r>10". B514 is quite flatted in the inner region, and has a larger half-light radius than majority of normal globular clusters of the same luminosity. It is interesting that, in the M_V versus log R_h plane, B514 lies nearly on the threshold for ordinary globular clusters as defined by Mackey & van den Bergh. In addition, B514 was observed as part of the Beijing-Arizona-Taiwan-Connecticut (BATC) Multicolor Sky Survey, using 13 intermediate-band filters covering a wavelength range of 3000--8500 \AA. Based on aperture photometry, we obtain its SEDs as defined by the 13 BATC filters. We determine the cluster's age and mass by comparing its SEDs (from 2267 to 20000{\AA}, comprising photometric data in the near-ultraviolet of GALEX, 5 SDSS bands, 13 BATC intermediate-band, and 2MASS near-infrared JHKs} filters) with theoretical stellar population synthesis models, resulting in age of $11.5\pm3.5$ Gyr. This age confirms the previous suggestion that B514 is an old GC in M31. B514 has a mass of $0.96-1.08 \times 10^6 \rm M_sun$, and is a medium-mass globular cluster in M31.Comment: Accepted for Publication in AJ, 18 pages, 6 figures and 9 table

Old stellar population synthesis: New age and mass estimates for Mayall II = G1

Mayall II = G1 is one of the most luminous globular clusters (GCs) in M31. Here, we determine its age and mass by comparing multicolor photometry with theoretical stellar population synthesis models. Based on far- and near-ultraviolet GALEX photometry, broad-band UBVRI, and infrared JHK_s 2MASS data, we construct the most extensive spectral energy distribution of G1 to date, spanning the wavelength range from 1538 to 20,000 A. A quantitative comparison with a variety of simple stellar population (SSP) models yields a mean age that is consistent with G1 being among the oldest building blocks of M31 and having formed within ~1.7 Gyr after the Big Bang. Irrespective of the SSP model or stellar initial mass function adopted, the resulting mass estimates (of order $10^7 M_\odot$) indicate that G1 is one of the most massive GCs in the Local Group. However, we speculate that the cluster's exceptionally high mass suggests that it may not be a genuine GC. We also derive that G1 may contain, on average, $(1.65\pm0.63)\times10^2 L_\odot$ far-ultraviolet-bright, hot, extreme horizontal-branch stars, depending on the SSP model adopted. On a generic level, we demonstrate that extensive multi-passband photometry coupled with SSP analysis enables one to obtain age estimates for old SSPs to a similar accuracy as from integrated spectroscopy or resolved stellar photometry, provided that some of the free parameters can be constrained independently.Comment: Accepted for Publication in RAA, 12 pages, 1 figure, 2 table

Market-based approaches to food safety and animal health interventions: Lessons from smallholder pig value chains in Vietnam

Food safety and animal health issues are increasingly important constraints to smallholder pig production in Viet Nam. Recent studies have highlighted the significant prevalence of animal disease and food‐borne pathogens inherent within the Vietnamese pig sector. These in turn have important negative livelihoods effects on smallholder pig producers and other value chain actors, as well as important public health impacts. An important research gap is in identifying ex‐ante appropriate market‐based policy responses that take into account the tradeoffs between improved animal health and food safety outcomes and their associated costs for different value chain actors as a means of developing chain‐level solutions for their control. In this paper, we constructed a system dynamics model of the pig value chain that combines a detailed model of herd production and marketing with modules on short‐ and long‐term investment in pig capacity, and decisions by value chain actors to adopt different innovations. The model further highlights the feedbacks between different actors in the chain to identify both the potential entry points for upgrading food safety and animal health as well as potential areas of tension within the chain that may undermine uptake. Model results demonstrate that interventions at nodal levels (e.g. only at farm or slaughterhouse level) are less cost‐effective and sustainable than those that jointly enhance incentives for control across the value chain, as weak links downstream undermine the ability of producers to sustain good health practices

Surface roughness dependent osteoblast and fibroblast response on poly(l-lactide) films and electrospun membranes

Poly(l-lactide) electrospun mats with random and aligned fiber orientation and films have been produced with degrees of crystallinity ranging from 0 up to nearly 50%. The overall surface roughness is practically constant irrespective of the sampling areas (1 × 1 µm to 20 × 20 µm) for degrees of crystallinity below 30%, increasing for higher degrees of crystallinity for the larger sampling areas. Further, due to fiber confinement, surface roughness variations are smaller in electrospun mats. Samples with 50% of crystallinity show the lowest osteoblast and the highest fibroblast proliferation. Therefore, it is verified that higher roughness promotes lower osteoblast but higher fibroblast proliferation. The overall results indicate the relevant role of the sub-microenvironment variations associated to the microscale roughness in determining the different cell responses.Portuguese Foundation for Science and Technology (FCT); contract grant numbers: C/FIS/UI607/2011, PTDC/CTM-NAN/112574/2009, contract grant numbers: SFRH/BPD/63148/2009, SFRH/BPD/90870/2012, Matepro—Optimizing Materials and Processes, Programa Operacional Regional do Norte, Quadro de Referência Estratégico Nacional” (QREN), “Fundo Europeu de Desenvolvimento Regional” (FEDER); contract grant number: NORTE-07–0124-FEDER-000037

Using a system dynamics framework to assess disease risks of pig value chains in Vietnam

In Vietnam, there are more than 4 million households producing pigs and pork. This accounts for 57% of quantity of meat consumed. One of the most critical constraints to pig production is the presence of animal disease. Pig disease outbreaks are a regular occurrence in various parts of the country, with the industry affected by diseases such as foot and mouth disease, porcine reproductive and respiratory syndrome, classical swine fever, porcine high fever disease, and swine influenza. In addition, food safety issues related to pig diseases and pork-borne diseases have also increasingly become more important concerns for consumers. Recent studies have shown significant changes in consumption behaviour in response to disease outbreaks. For instance, at least half of urban consumers stop consuming pork in times of pig disease epidemics and/or shift consumption to other meat substitutes such as poultry or fish. Disease risks thus have both public health and livelihoods impacts that are important to understand for appropriate policy and practice response. A proposed methodology for investigating disease risks uses a system dynamics analysis framework. System dynamics models are particularly relevant in the study of livestock systems, as they capture the diverse actors and feedbacks present in value chains and their interface with disease risk and behaviour. A system dynamics model is developed that will describe different scenarios of disease risks and the consequences of different interventions to mitigate these risks. Data from a sample of 1000 farmers and value chain actors including all actors in the pig value chain in Vietnam was collected with support from an ACIAR-funded project on Reducing Disease Risks and Improving Food Safety in Smallholder Pig Value Chains in Vietnam. We propose to test the hypotheses that disease risk is affected by type of production system, feeding system and types of feed uses, access to inputs and services, and selected socio-demographic variables associated with farmers and location

Quantum flavor oscillations extended to the Dirac theory

This report deals with the quantum theory of flavor oscillations in vacuum, extended to fermionic particles in the several subtle aspects of the first and second quantization theories. In this scenario, the use of the Dirac equation is required for a satisfactory evolution of fermionic mass-eigenstates since in the standard treatment of oscillations the mass-eigenstates are implicitly assumed to be scalars and, consequently, the spinorial form of neutrino wave functions is not included in the calculations. Within first quantized theories, besides flavor oscillations, chiral oscillations automatically appear when we set the dynamic equations for a fermionic Dirac-type particle. The left-handed chiral nature of created and detected neutrinos can be implemented in the first quantized Dirac theory in presence of mixing; the probability loss due to the changing of initially left-handed neutrinos to the undetected right-handed neutrinos can be obtained in analytic form. In the context of a causal relativistic theory of a free particle, one of the two effects should be present in flavor oscillations: (a) rapid oscillations or (b) initial flavor violation. Concerning second quantized approaches, a simple second quantized treatment exhibits a tiny but inevitable initial flavor violation without the possibility of rapid oscillations. Such effect is a consequence of an intrinsically indefinite but approximately well defined neutrino flavor. The violation effects are shown to be much larger than loop induced lepton flavor violation processes, already present in the standard model in the presence of massive neutrinos with mixing. The conclusions of this report lead to lessons concerning flavor mixing, chiral oscillations, interference between positive and negative frequency components of Dirac equation solutions, and the field formulation of quantum oscillations.Comment: 116 pages, 10 figures (The abstract was suppressed due to online title limitations of the abstract field. See the manuscript for obtaining the complete abstract

Spatial Periodicity of Galaxy Number Counts, CMB Anisotropy, and SNIa Hubble Diagram Based on the Universe Accompanied by a Non-Minimally Coupled Scalar Field

We have succeeded in establishing a cosmological model with a non-minimally coupled scalar field $\phi$ that can account not only for the spatial periodicity or the {\it picket-fence structure} exhibited by the galaxy $N$-$z$ relation of the 2dF survey but also for the spatial power spectrum of the cosmic microwave background radiation (CMB) temperature anisotropy observed by the WMAP satellite. The Hubble diagram of our model also compares well with the observation of Type Ia supernovae. The scalar field of our model universe starts from an extremely small value at around the nucleosynthesis epoch, remains in that state for sufficiently long periods, allowing sufficient time for the CMB temperature anisotropy to form, and then starts to grow in magnitude at the redshift $z$ of $\sim 1$, followed by a damping oscillation which is required to reproduce the observed picket-fence structure of the $N$-$z$ relation. To realize such behavior of the scalar field, we have found it necessary to introduce a new form of potential $V(\phi)\propto \phi^2\exp(-q\phi^2)$, with $q$ being a constant. Through this parameter $q$, we can control the epoch at which the scalar field starts growing.Comment: 19 pages, 18 figures, Accepted for publication in Astrophysics & Space Scienc

Oscillations of neutrinos and mesons in quantum field theory

This report deals with the quantum field theory of particle oscillations in vacuum. We first review the various controversies regarding quantum-mechanical derivations of the oscillation formula, as well as the different field-theoretical approaches proposed to settle them. We then clear up the contradictions between the existing field-theoretical treatments by a thorough study of the external wave packet model. In particular, we show that the latter includes stationary models as a subcase. In addition, we explicitly compute decoherence terms, which destroy interferences, in order to prove that the coherence length can be increased without bound by more accurate energy measurements. We show that decoherence originates not only in the width and in the separation of wave packets, but also in their spreading through space-time. In this review, we neither assume the relativistic limit nor the stability of oscillating particles, so that the oscillation formula derived with field-theoretical methods can be applied not only to neutrinos but also to neutral K and B mesons. Finally, we discuss oscillations of correlated particles in the same framework.Comment: v2, 124 pages, 10 figures (7 more); updated review of the literature; complete derivation of the oscillation probability at short and large distance; more details on the influence of the spreading of the amplitude on decoherence; submitted to Physics Report

Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection.

BackgroundHIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. ET-1 is a robust vasoconstrictor and key mediator of pulmonary vascular homeostasis. Higher levels of ET-1 predict disease severity and mortality in other forms of PAH, and endothelin receptor antagonists are central to treatment, including in HIV-associated PAH. The direct relationship between ET-1 and PAH in HIV-infected individuals is not well described.MethodsWe measured ET-1 and estimated pulmonary artery systolic pressure (PASP) with transthoracic echocardiography (TTE) in 106 HIV-infected individuals. Participants with a PASP ≥ 30 mmHg (n = 65) underwent right heart catheterization (RHC) to definitively diagnose PAH. We conducted multivariable analysis to identify factors associated with PAH.ResultsAmong 106 HIV-infected participants, 80% were male, the median age was 52 years and 77% were on antiretroviral therapy. ET-1 was significantly associated with higher values of PASP [14% per 0.1 pg/mL increase in ET-1, p = 0.05] and PASP ≥ 30 mmHg [PR (prevalence ratio) = 1.24, p = 0.012] on TTE after multivariable adjustment for PAH risk factors. Similarly, among the 65 individuals who underwent RHC, ET-1 was significantly associated with higher values of mean pulmonary artery pressure and PAH (34%, p = 0.003 and PR = 2.43, p = 0.032, respectively) in the multivariable analyses.ConclusionsHigher levels of ET-1 are independently associated with HIV-associated PAH as hemodynamically assessed by RHC. Our findings suggest that excessive ET-1 production in the setting of HIV infection impairs pulmonary endothelial function and contributes to the development of PAH